Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"glucose-6-phosphatase"”.
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… an autosomal recessive IEM caused by defects in Glucose-6-Phosphatase, Catalytic Subunit (G6PC), the terminal enzyme in both glycogenolysis and gluconeogenesis. Fasting hypoglycemia, a prominent symptom of GSD1a, is understandable because of G6PC's role in hepatic glucose output. Other metabolic …
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The Localization of Glucose-6 Phosphatase in Developing Rat Liver: A Histochemical and Biochemical Study
<p>The distribution of glucose-6-phosphatase activity in rat hepatocytes during a period of rapid cell and membrane differentiation was studied by electron microscopic histochemistry. Livers from animals 4 days before to 1 day after birth were perfused with 2% glutaraldehyde in the presence of 6 mM …
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CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
In the NOD mouse, islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is an important β cell autoantigen recognized by a majority of cytotoxic CD8+ T cells. This study investigates two IGRP peptides (P3 and P7) which contain MHC class Il-specific CD4+ T cell epitopes. …
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Mutationsanlyse bei Patienten mit Glykogenose Typ Ia
… Aktivität der katalytischen Untereinheit des Glucose-6-Phosphatase-Enzymkomplexes, kodiert durch das Glucose-6-Phosphatase-Gen. Dieses Enzymsystem katalysiert sowohl den letzten Schritt der Glykogenolyse, als auch der Gluconeogenese und besitzt somit eine Schlüsselfunktion im …
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The Development of Certain Enzymes and Iso-Enzymes During Normal Pregnancy
… γ-glutamyl transpeptidase, alkaline phosphatase, glucose-6-phosphatase, 5-nucleotidase, n-acetyl-β-glucosaminidase, n-acetyl-β-galactosaminidase and β-glucuronidase, have been found to progressively increase. Dipeptidase and tripeptidase were not found to increase during pregnancy. A …
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Protective potential of fruits against diabetes and its complications
… (PAC-h) inhibited expression of glucose-6-phosphatase in a dose dependent manner. In addition, anthocyanins from V. trilobum interacted with the PAC-h in an additive manner to inhibit expression of glucose-6-phosphatase in vitro. Flavonoid-rich, anthocyanin-rich (ANC), and …
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The effect of magnesium deficiency on the gluconeogenic enzymes with emphasis on the effects of fasting and anorexia
… the following parameters were measured: blood glucose and plasma magnesium, liver magnesium and protein, and the activities of liver glucose-6-phosphatase (G6Pase), fructose 1, 6-bisphosphatase (FDPase), and phosphoenolpyruvate carboxykinase (PEPCK). In Experiments II and III rats were meal-fed …
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… condition is characterized by deregulation of glucose homeostasis through the development of insulin resistance, manifested as increased glucose production in the liver. Hepatic gluconeogenesis provides de novo formation of glucose from three carbon precursors such as glycerol, lactate, …
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Metabolic and hormonal responses in the regulation of blood glucose levels in infants delivered by elective caesarean section
… postnatal failures of expression of the hepatic glucose-6-phosphatase system suggest there are developmental deficiencies in the mechanism to ‘switch-on’ this key enzyme of gluconeogenesis at the time of birth in both preterm and term infants. The evidence for hormonal regulation of this critical …
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Multi-Nuclear NMR Studies of Phospholipid Membranes and their Interaction with Membrane Active Substances
… by general anaesthetics of the hydrolysis of glucose-6-phosphate by the enzyme glucose-6-phosphatase which further supported the above conclusions on anaesthetic action.<br/>
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Beyond the allosteric role of Fructose-2,6-bisphosphate: exploring its effects on gene expression and signal transduction.
… not available or not effective in suppressing glucose output by the liver. Enhancing hepatic glucose flux through glycolysis by raising fructose-2,6-bisphosphate (F26BP) levels ameliorates the diabetic phenotype in type 1 and type 2 diabetic mouse models (WU et al. 2001b; WU et al. 2002). This …
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Health Effects of Dietary Fermentable Fiber (Resistant Starch)
… expression of pyruvate carboxylase (PCase), and glucose-6-phosphatase (G6Pase). These two enzymes are involved in intestinal gluconeogenesis (IGN) which improves endogenous glucose control. Certain diets can trigger IGN. Goto-Kakizaki (GK) rats (first) and Sprague Dawley rats (second) were used …
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Therapeutic Effect of a triterpenic Acid from Protorhus longifolia Against High Fat Diet Fed and Streptozotocin-induced Diabetic Nephropathy in Rats
… with RA5 (100 mg/kg) for 14 days and the oral glucose tolerance of the rats was determined. In the HFD fed and STZ induced diabetic nephropathy in rat model, the HFD fed (hyperlipidaemic) rats received an intraperitoneal injection of a low dose of STZ (30 mg/kg) to induce diabetes. The diabetic …
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The Golgi Complex of the Hepatocyte: Isolation and Partial Enzomological Characterization
… no detectable RNA. They have no detectable glucose-6-phosphatase, NADPH-cytochrome c reductase, or cytochrome P-450 activity, all enzymes associated with microsomal fractions, and their specific activity for NADH-cytochrome c reductase and cytochrome b5, enzymes associated with both …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
… 5 months (mo) improved insulin sensitivity and glucose tolerances, which were associated with increased Glut4 and AMPKα expression in muscle and adipose tissues in middle-aged mice fed a high-fat (HF) diet. In vitro, kaempferol increased lipolysis and restored chronic high fatty acid-impaired …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
… of circadian clocks, fat metabolism and glucose homeostasis. In the first aim, I have tested whether AhR interacts with the core clock gene, brain and muscle AhR nuclear translocator like-1(BMAL1), disrupting circadian locomotor output cycle kaput (CLOCK)/BMAL1 complex activity, and …
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From cancer gene expression to protein interaction: Interaction prediction, network reasoning and applications in pancreatic cancer
… identified the inhibition of the enzyme glucose-6-phosphatase as responsible for the Glycogen storage disease type I, which according to literature is known to be the main reason for this disease. Furthermore, BioRevise was used to model reaction inhibition in the Glycolysis pathway which …
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Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function
Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce …