Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"glucose transporter"”.
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Role of glucose transporter 1 during pregnancy
… gene profiling has shown that Hif2α regulates Glucose transporter1 (GLUT1). GLUT1 is the dominant glucose transporter in the uterus and has been linked to human infertility. Based on these points, we chose to investigate the role of GLUT1 in pregnancy by deleting GLUT1 from the uterus using two …
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Insulin Regulated Trafficking of Glucose Transporter 4: A Kinetic Perspective
Regulation of blood glucose homeostasis is a critical process; defects in this process can lead to insulin resistance, type II diabetes, and metabolic syndrome. Glucose homeostasis is regulated in part by insulin action on peripheral tissues, especially muscle, fat, and the liver. In muscle and …
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Regulation of skeletal muscle glucose transporter 4 expression in fructose-fed exercised rats
… found that the expression of skeletal muscle glucose transporter 4 (GLUT4) is decreased by high fructose consumption but increased by exercise. However, the amounts of fructose used in these studies were extremely high and the effects of moderate feeding protocols are not known. While it is …
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Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
As glucose is the main fuel source for the brain and a major nutrient for peripheral tissues, the brain must sense and respond to changes in blood glucose in order to sustain its own nutritional requirements and maintain whole body energy homeostasis. Disruption of brain glucose sensing results in …
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EXPANSION OF CLINICAL PHENOTYPE AND USE OF KETOGENIC DIET IN RARE GENETIC CONDITIONS: GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME AND SCN8A-RELATED DISORDERS
… on the study of two rare genetic disorders: Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS) and conditions associated with pathogenic variants in the SCN8A gene. The aim was to expand the understanding of the clinical phenotype and disease progression, as well as to evaluate the …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
The existence and function of glucose metabolism in the outer segments of photoreceptor cells were investigated using biochemical and immunocytochemical approaches. The presence of glycolytic enzymes in photoreceptor outer segments was detected by enzyme activity assays, Western blotting, and …
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Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.
… increased in both groups (p<0.05). Expression of glucose transporter protein-4 (GLUT4), the principle insulin-responsive glucose transporter, increased significantly in both groups. 5-adenosine monophosphateactivated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) expression …
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Molecular Mechanisms by which a Grape Seed Procyanidin Extract Modulates Glucose Homeostasis
… resulted in 5.1 million deaths in 2013. Blood glucose levels are tightly regulated in order to maintain metabolic homeostasis. The hormone insulin, after binding to the insulin receptor, initiates a well-established controlled metabolic signaling cascade that consequently lowers blood glucose …
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Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A
… respiratory factor (NRF)-1 in mice increases glucose transporter (GLUT)-4 and myocyte enhancer factor (MEF-) 2A content, but the mechanisms have not been elucidated. Because NRF-1 has a binding site on the mef2a gene, and MEF2A binds the glut4 gene as a MEF2A-MEF2D heterodimer, the aims of …
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The impact of placental SLC2A3 (GLUT-3) RNA interference on fetal growth and physiology at mid-gestation in sheep
Glucose is the primary energy substrate for fetal oxidative processes and growth. In order for glucose to be transported from maternal to fetal circulation in the ruminant placenta, it must be sequentially transported by SLC2A1 (GLUT-1) on the maternal-fetal syncytial layer, then by SLC2A3 (GLUT-3) …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
Glucose and lipid metabolism are dysregulated in obese horses. Altered glucose metabolism is evidenced by the development of insulin resistance and increased fasting plasma insulin concentrations (hyperinsulinemia) while altered lipid metabolism is evidenced by increased plasma lipid …
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ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
… been found to be beneficial on two levels. 1) Glucose uptake is increased in exercising skeletal muscle, which is crucial as skeletal muscle accounts for ~85% of insulin-stimulated glucose uptake and the insulin effect is blunted in type 2 diabetes. 2) Post resistance exercise, muscle protein …
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The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells
… secondary metabolites and extracts on glucose metabolism in Hep G2 cellular models. The primary objective of this project is to evaluate and compare the metabolic activities of Hep G2 cells after treatment with pure compounds phloretin, ouabain, berberine, and metformin, rebaudioside-A, …
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Regulation of the Mannose PTS Operon by the small RNA SgrS
… genes. The sRNA SgrS is expressed in response to glucose-phosphate stress, a condition associated with disruption of glycolytic flux and accumulation of sugar-phosphates. SgrS has been shown to stimulate degradation of the ptsG mRNA, encoding the major glucose transporter. This study demonstrates …
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Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium
… in the content of the insulin-regulatable glucose transporter (GLUT4) in skeletal muscle (84). Understanding the mechanisms by which exercise increases GLUT4 levels in skeletal muscle may reveal targets for pharmaceuticals to treat insulin resistance and type II diabetes. Although in vitro …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments utilizing an <em>in-vitro</em> GBM model. The …
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TIME COURSE OF SIGNALING PROCESSES INVOLVED WITH EXTRACELLULAR OSMOTIC - INDUCED GLUCOSE UPTAKE IN MAMMALIAN SKELETAL MUSCLE
… hyper-osmotic (HYPER) stress increases glucose uptake to defend cell volume, when compared to iso-osmotic (ISO) conditions in skeletal muscle. The purpose of this study was to determine a time course for changes in common signaling proteins involved in glucose uptake during acute …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… has been involved in insulin signalling and/or glucose homeostasis. LRRK2 is also expressed in the endocrine pancreas but here its role is completely unknown. Using molecular and pharmacological approaches, the overall aim of this project was to characterize LRRK2 activity in cells involved in …
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