Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"glucose sensor"”.
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A Novel Glucose Sensor Based on a Deflecting Membrane MEMS Device
Self-monitoring of blood glucose has become an important and critical tool for effective management of patients with diabetes. This thesis describes a novel MEMS (Microelectromechanical systems) sensor that can continuously measure, in real time, the concentration of glucose in a solution. The …
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Development and in-vitro evaluation of a potentially implantable fibre-optic glucose sensor probe
… Insulin allows the cells of the body to extract glucose from the blood supply to use as fuel. Without insulin the cells turn to other backup fuel sources,this can cause side effects that are quickly fatal or gradual wasting of the bodies tissues. The use of insulin, however, is not danger free, …
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SYNTHESIS AND CHARACTERIZATION OF HIGHLY FLUORESCENT TUNABLE AZABORINE PHOTO-INDUCED ELECTRON TRANSFER GLUCOSE SENSOR
<p>The process of detecting glucose is useful in tracking and obtaining rapid results regarding the presence and amount of glucose within a biological system. Over the past decades, boronic acid derivatives such as <em>ortho</em>-aminomethyl phenylboronic acid have been utilized heavily in glucose …
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Effects of Localized Oxygen Production by Electrolysis on the First-Generation Glucose Sensor Response
<p>Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in …
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Modulation of Single-Walled Carbon Nanotube Fluorescence via Enzyme Reaction, Controlled Aggregation and Hydrogel Swelling Towards a Continuous Glucose Sensor
… production of an implantable continuous analyte sensor. Single-walled carbon nanotubes (SWNT) have a tunable excitation and emission in the near-infrared (nIR) and do not photobleach. Additionally, their quasi one-dimensional nature renders them sensitive to molecular adsorption events. We …
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Fluorescence photophysics, characterisation and application of labelled glucose/galactose binding protein
… for reliable, minimally-invasive, continuous glucose monitoring for the treatment of diabetes mellitus. One promising glucose sensor is bacterially-derived glucose binding protein (GBP). In this project, the modified triple mutant H152C/A213R/L238S-GBP (mGBP) was investigated for viability as …
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Holographic Point-of-Care Diagnostic Devices
… is currently no rapid, low-cost and generic sensor fabrication technique capable of producing narrow-band, uniform, reversible colorimetric readouts with a high-tuneability range. This thesis aims to present a theoretical and experimental basis for the rapid fabrication, optimisation and …
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Genetic and Molecular Analysis of Islet-and Liver-Enriched Transcription Factors in Metabolism and Development
… genetic defects in the glucokinase gene, the glucose sensor of the pancreatic β-cells, and the insulin gene also lead to impaired glucose tolerance. Using molecular and genetic approaches, we demonstrated that the MODY genes are functionally related and form an integrated transcriptional …
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Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… biogenesis is induced. Puf3 functions as a glucose sensor in yeast to support mitochondrial biogenesis in respiratory conditions. It facilitates a rapid stabilization of its target transcripts, such as cytochrome c oxidase components. Yeast-Ataxin2, Pbp1, is a poly(A)tail binding protein and …
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The impact of closed-loop insulin delivery on glucose control in children and young people with type 1 diabetes mellitus: Longer-term benefits across the paediatric age-spectrum
… insulin delivery systems, consisting of glucose sensor, insulin pump and an algorithm automatically adjusting insulin delivery in response to real-time glucose levels, have the potential to transform diabetes management. Longer-term unsupervised studies had been lacking across the …
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Design and synthesis of polymers for Corona Phase Molecular Recognition (CoPhMoRe) of carbohydrates
… backbone structure, highly selective D-Arabinose sensor was developed and used to differentiate D-Arabinose from L-Arabinose for the first time. Finally we developed a glucose sensor that can measure glucose concentration instantaneously by detecting changes in local refractive index.
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SERS-based nanoparticle biodetection using carbohydrate-lectin interactions
… with unique surface functionality, for example, glucose or galactose. Additionally, functionalising the particles with Raman reporter molecules (RRMs) resulted in the measurement of surface enhanced Raman scattering (SERS) signals. Aggregation of the glyconanoparticles in the presence of a …
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The development of a minimally invasive glucose sensing system
… this research is to develop a minimally invasive glucose sensing system for diabetic patients. The device will consist of an array of micro-needles that penetrates only the stratum corneum layer of the skin and tests glucose levels in the interstitial fluid (IF). This device does not reach the …
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Glucose monitoring measuring blood glucose using vertical cavity surface emitting lasers (VCSELs)
… ever-increasing public health issue. Continuous glucose monitoring has been shown to help diabetes mellitus patients stabilize their glucose levels, leading to improved patient health. Hence, a glucose sensor, capable of continuous real-time monitoring, has been a topic of research for three …
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Optical fibre-based minimally-invasive blood glucose monitoring system.
… can be controlled by tightly monitoring blood glucose levels. Several methods to accomplish this have been proposed over the years. In this thesis, a thorough literature and patent review revealed that blood glucose monitors (BGMs) based on amperometry are one of the most common technologies to …
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Development of Electrochemical Biosensors for Potential Liver Disease Detections of ALT & AST and Application of Ionic Liquid into Biosensing-Modified Electrodes
… aminotransferase (AST). The proposed biosensor technology provided a useful tool for potential clinical-screening of liver status.Iridium (Ir) nanoparticles possessed excellent electrocatalytic activity and its incorporation into the biosensor provided excellent detection of H2O2 …
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Solution-gated graphene transistors for chemical and biological sensing applications
… to make graphene-based chemical and biological sensors on different substrates. Single-layer graphene is grown by chemical vapor deposition and then transferred to silicon dioxide as well as PolyEthylene Naphthalate (PEN) substrate, where graphene solution-gated field-effect transistors (SGFET) …
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Development and evaluation of glucose-responsive biomaterials as self-regulated insulin delivery systems
… begins to address current limitations of such glucose-responsive insulin delivery systems by developing novel biomaterial-based formulations Results This Thesis presents 3 types of glucose-responsive insulin delivery systems developed during my PhD Each system employs the enzyme glucose oxidase …
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Development and Optimization of an Integrated Faraday Modulator and Compensator Design for Continuous Polarimetric Glucose Monitoring
… in the development of noninvasive polarimetric glucose detection systems, salutary for the treatment of our rapidly increasing diabetic population. This area of research utilizes the aqueous humor as the detection medium for its strong correlation to blood glucose concentration and highlights …
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From mechanism to application: a look at the CuBTTri-catalyzed decomposition of S-nitrosoglutathione
… a MOF-polymer composite onto the surface of a glucose sensor and evaluating its impact.
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