Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"glucose sensitivity"”.
-
Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
… may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\rm I\sb{A}$ in the prediabetic $\beta$-cell. Enhanced expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production …
-
Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… obesity, with reduced adiposity and enhanced glucose sensitivity. Although Epac1 knockout (KO) mice have significantly lower plasma leptin, an important hormone for controlling energy homeostasis, the leptin sensitivity in hypothalamus is greatly enhanced compared to wild-type (WT) …
-
Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… obesity, with reduced adiposity and enhanced glucose sensitivity. Although Epac1 knockout (KO) mice have significantly lower plasma leptin, an important hormone for controlling energy homeostasis, the leptin sensitivity in hypothalamus is greatly enhanced compared to wild-type (WT) …
-
Investigation into reliability and performance of an implantable closed-loop insulin delivery device
… delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. …
-
Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
… to achieve a more physiological profile of glucose homeostasis. Somatic cell gene therapy offers the prospect that insulin could be delivered by an autologous cell implant, engineered to secrete insulin in response to glucose. This study explores the feasibility of manipulating somatic cells …
-
Search for molecular and metabolic mechanisms contributing to impaired β-cell function
… secreting β-cell lines with good and poor glucose responsiveness, respectably. The cell line with poor glucose responsiveness showed increased lactate production and glycolytic flux but decreased ATP production, suggesting a disturbed coupling between glycolytic flux and mitochondrial …
-
Intelligent Nano/Microgels for Cell Scaffold and Drug Delivery System
… 6 investigated a class of well-defined glucose-sensitive microgels as an insulin drug release carrier, obtained via polymerization of 4-vinylphenylboronic acid (VPBA), 2-(dimethylamino) ethyl acrylate (DMAEA), and andoligo(ethylene glycol)methyl ether methacrylate (MEO5MA). The presence …
-
Effects of Localized Oxygen Production by Electrolysis on the First-Generation Glucose Sensor Response
<p>Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in …