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Showing 1 to 20 of 36 for “"glucose production"”.
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Mechanisms of Glucose Production by Liver Cells
Made available in DSpace on 2014-12-05T19:37:27Z (GMT). No. of bitstreams: 1 6003885.pdf: 3189820 bytes, checksum: f9fd18c754f4f7026d440b64a6a1c11e (MD5) Previous issue date: 1960
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Endogenous glucose production and gluconeogenesis during exercise in athletes on either a low-carbohydrate or mixed diet
… high. The most probable source of this glucose is via the process of gluconeogenesis (GNG). However, endogenous glucose production (EGP) and GNG has not been studied during exercise in athletes on a LCHF diet. Therefore, the aim of this study was to determine if there are differences in …
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… condition is characterized by deregulation of glucose homeostasis through the development of insulin resistance, manifested as increased glucose production in the liver. Hepatic gluconeogenesis provides de novo formation of glucose from three carbon precursors such as glycerol, lactate, …
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Genomic analysis of hepatic insulin resistance
… researchers are investigating the genetics of glucose homeostasis, however, traditional mapping techniques have not been successful in determining all of the genes that regulate glycemia. To complement these efforts, we used DNA microarrays to find differentially expressed genes and …
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Gluconeogenesis in the liver of growing and lactating ruminants: the influence of ration composition and stage of lactation
… Metabolic body weight, liver weight and blood glucose were greatest in CONC-fed calves. Neither dry matter nor ash content of liver tissue was affected by either physical form or RDN. Within physical form, protein content was highest and fat lowest in livers of CH-fed caIves. Within RDN, livers …
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
… by hormones insulin and glucagon is central to glucose homeostasis. Recent work has proposed that amongst the salt inducible kinase isoforms (SIK1, 2 and 3), members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in the control of insulin- and …
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An Extensible Mathematical Model of Glucose Metabolism
… care dollars.</p> <p>One must understand the glucose regulatory system of the healthy body to understand diabetes. Blood glucose concentration returns to a constant level after eating and is maintained during exercise. With thousands of chemical reactions involved in the process, a complete …
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Regulation of the Nuclear Factor of Activated T Cell (NFAT) Family of Transcription Factors in the Freeze Tolerant Wood Frog, Rana sylvatica
… repression (the latter potentially linked with glucose production as a cryoprotectant). Anoxia activated NFATc4 in liver, leading to increased atrial natriuretic peptide levels. Neither freezing nor anoxia significantly affected NFATs in skeletal muscle. Overall, the study indicates that NFATs …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… cause fasting hyperglycemia or elevated hepatic glucose output. In concordance with those findings we observed that dioxin treatment caused a strong suppression of the expression of the key hepatic gluconeogenic genes PEPCK and G6Pase. However, this suppression was not solely mediated by the …
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Glucose Metabolism in Low Birth Weight Neonatal Pigs
… dissertation was that in utero disturbances in glucose metabolism and increased energy requirements predisposes LBWT neonatal pigs to metabolic disturbances after birth. We sought to increase growth of skeletal muscle and improve glucose production through increasing dietary energy and to …
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Preliminary investigations for studying the effects of low carbohydrate high fat diets on gluconeogenesis in type 2 diabetes patients
… One such mechanism is the dysregulation of glucose production via gluconeogenesis, which is a key pathology of T2D but which has been incompletely studied. Indeed, the effects of LCHF eating on gluconeogenesis in T2D patients has not yet been studied, nor has gluconeogenesis been …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… mice. Oral administration of kaempferol improved glucose intolerance and insulin sensitivity, and this effect was associated with increased Glut4 and AMPKa expression in muscle and adipose tissues. Consistent with our findings from the in iii vitro study in C2C12 muscle cell line, these findings …
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The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
… elevated energy mobilization through increased glucose production and lipolysis. These metabolic changes contribute to the morbidity associated with delayed recovery. Hyperglycemia, increased infections, insulin resistance, delayed wound healing, and organ dysfunction are all associated with …
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The Path to an Orally Administered Protein Therapeutic for the Treatment of Diabetes Mellitus
… norms through direct effects on hepatic glucose production. The major problem facing oral delivery of protein therapeutics is gastrointestinal tract hydrolysis/proteolysis and the inability to passage the enterocyte. Herein we report the potential use of vitamin B<sub>12</sub> for the …
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The interaction between glucose and fat metabolism and insulin resistance in severely burned children and the metabolic effects of fenofibrate
… in conjunction with disturbances in fat and glucose metabolism and mitochondrial dysfunction. Four human studies were conducted to better understand this relationship in the settings of aging and burn trauma. \r\nThe first two studies focused on aging. Insulin resistance commonly occurs in …
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Energy Homeostasis During Fasting and Fed States: Foxa2 Regulates Hepatic Amino Acid Uptake
… intake to increase its substrate pool for glucose production. We found that mNAT3 is upregulated during fasting, and that this response is abolished with insulin. Using mice injected with adenovirus expressing either Foxa2 or GFP as a control, we found that Foxa2 mediates this …
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Mathematical modelling of blood glucose regulation
… to model the effects of exercise on the glucose regulatory system, for both healthy and diabetic individuals. A particular focus is given to the role of glucagon, whose role is often neglected in glucoregulatory models, and its ability to enhance hepatic glucose production and so to …
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
… by phosphorylation to conserve substrates for glucose production. To assess the importance of PDK2 and PDK4 in regulation of the PDC to maintain glucose homeostasis, PDK2 knockout (KO), PDK4 KO, and PDK2/PDK4 double knockout (DKO) mice were generated. PDK2 deficiency caused higher PDC activity …
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SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice
… effects including reduced adiposity and improved glucose homeostasis, as well as enhanced insulin and leptin sensitivity. Conversely, chronic feeding on high caloric diets brings about opposite outcomes and can progress to type-II-diabetes and obesity. An intense effort by many researchers has …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… in the liver. Though amino acid, fatty acid, and glucose metabolism of the small intestine have been well studied, no investigation has emphasized the role of intestinal PEPCK in these pathways. The aim of this work is to examine the roles of PEPCK in small intestine function and metabolism. A …
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