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Showing 1 to 20 of 39 for “"glucose oxidation"”.
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Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man
… absorption and subsequent transport of glucose into the systemic circulation, and iii) the rate of glucose uptake and oxidation by the working muscles. To test the hypothesis that the rate of gastric emptying is the primary factor limiting the rate of CHO delivery to the working muscles …
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On chemical stimulation in rat erythrocytes of glucose oxidation via the pentose pathway, and the inhibition of this stimulation by sodium chromate and 2,5-dinitrobenzoic acid
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Επίδραση των δεξαμενών CO₂ στην εμφάνιση ισοτοπικού άνθρακα στην εκπνοή
… after oral intake of "naturally labelled" 13C-glucose at rest and during muscular exercise. Our results demonstrate that: 1) at rest, discrepancies between total carbohydrates consumption and exogenous glucose oxidation concerning the peak occurrence time, as well as the absolute quantities, …
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The Role of Angiotensin II in Skeletal Muscle Metabolism
… number of effects were investigated. Fatty acid oxidation and lipid synthesis was measured using [1-14C]-palmitate, glucose oxidation and glycogen synthesis were measured using 14C-glucose. In addition,mitochondrial oxidative capacity was measured using an XF 24 Flux Analyzer (Seahorse …
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Fuel kinetics during intense running and cycling when fed carbohydrate
… subjects drank 250 ml of a 15 g.100 ml⁻¹ w.v⁻¹ glucose solution with U-¹⁴C glucose added as tracer and, thereafter, 150 ml of the same solution every 15 min. Despite identical metabolic rates (VO₂ 3.51 ±0.06 vs. 3.51 ±0.10 l.min⁻¹; values are mean± SEM for the cycling and running trials, …
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An in vitro study of the effects of free fatty acids on insulin mediated glucose uptake and metabolism by myocytes and fibroblast derived adipocytes
… tissues involved with post-prandial peripheral glucose disposal in response to insulin. Insulin resistance reduces the ability to clear glucose from the circulation resulting in hyperinsulinemia and hyperglycemia with the development of T2D. High levels of plasma free fatty acids (FFAs), …
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The Role of Pyruvate Dehydrogenase in Cell Growth
… that tumor cells have increased rates of glucose uptake and lactate secretion in comparison to normal cells spawned his notion that tumors have dysfunctional mitochondria. However, in addition to metabolizing glucose to lactate, tumors in vivo exhibit mitochondrial glucose oxidation, …
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Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
… signaling, as well as decreased fatty acid and glucose oxidation. Utilizing proteomic analysis of metabolic proteins in humans may lead to the mechanism behind skeletal muscle adaption to macronutrient composition, potentially providing the groundwork for characterizing the etiology of high-fat …
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A Mechanism for the Metabolic and Inflammatory Alterations Associated with Low-dose Endotoxemia
… after LPS challenge, suppressing lipid oxidation and concurrently up-regulating glucose oxidation. Unfortunately, this switch in metabolism is inefficient for the great energy demands of the host during a systemic microbial infection which can result in vital organ failure. Meanwhile, a …
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Skeletal Muscle Substrate Metabolism following a High Fat Diet in Sedentary and Endurance Trained Males
… by the resistance to switching substrate oxidation preference based on substrate availability and can be measured in either fasted or insulin-stimulated conditions. As the largest site for glucose disposal and a primary tissue influencing regulation of blood glucose concentrations, …
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The Role of Metabolic Inflexibility in Heart Failure
… HFpEF progression, and 2) test the necessity of glucose oxidation for left ventricular hypertrophy development and progression to HF. Since pyruvate dehydrogenase (PDH) kinase 4 (PDK4) is the predominant PDK found in the heart and PDK4 expression in the heart increases with high circulating fat …
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
… insulin sensitivity in cell culture, as well as glucose oxidation in the myotubes of severely obese individuals despite suppressed responses compared to lean counterparts. The molecular mechanism involved appeared to be an increased activation of AMPK phosphorylation in both subject groups while …
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The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… metabolically by increasing its reliance on glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of …
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IN VITRO ΑΝΑΠΤΥΞΗ ΑΝΤΟΧΗΣ ΠΡΟΤΥΠΟΥ ΣΤΕΛΕΧΟΥΣ PSEUDOMONAS AERUGINOSA ΣΤΟ ΙΜΙΡΕΝΕΜ ΚΑΙ ΙΔΙΟΤΗΤΕΣ ΑΥΤΟΥ
… PIGMENT PRODUCTION, GROWTH OF 42 C AND GLUCOSE OXIDATION. BETA-LACTAMASE ASSAYS SHOWED THATTHE MOST LIKELY REASON FOR THE RESISTANCE WAS THE EXISTENCE OF AN INCREASE PERMEABILITY BARRIER WHOSE MECHANISM WAS CHIEFLY BASED UPON IRREVERSIBLE PROCESSES. THESE PROCESSES WERE THE ALTERATIONS …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… hindered ability to properly transition from fat oxidation while in a fasted state to carbohydrate oxidation once fed, leading to a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial membranes, …
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The Influence of Ovarian Sex Steroids on Insulin Receptor Status in Mice
… reduction in the ability of insulin to promote glucose oxidation in skeletal muscle. This effect might also have been due to a reduction in insulin action in the liver, a possibility that was suggested by the reduced insulin binding capacity of hepatocytes and a reduction in liver glycogen …
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Interactive Effects of Macronutrients on Obesity and Metabolic Syndrome Development
… (F0, F20, and F40, percent energy, replacing glucose). Body composition was measured at the beginning and end points. P10 groups showed higher energy intake (P<0.0001) and percent fat (P<0.01) compared to P25 groups. Unexpectedly, replacing glucose with fructose attenuated this low protein …
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Model-Based Experimental Investigation of Hydrogenase-Like Electrocatalytic Inactivation and Activation Mechanisms
… These stepwise studies support a mechanism for glucose oxidation that proceeds most likely through a complex electrocatalytic (EC’CE) scheme with catalytic steps similar to the ones reported for [NiFe] hydrogenases. The overall mechanism of the molecular inactivation and activation process (IAP) …
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… white adipocytes and uncoupled fatty acid (FA) oxidation and UCP1 protein levels in the BAT. These effects could potentially be attributed to the shift to the counterregulatory RAS arm in WAT observed in study 2, which has been shown to produce beneficial metabolic effects. In study 3, the …
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