Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 157 for “"glucose homeostasis"”.
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A Preoptic Neurocircuit that Regulates Blood Glucose Homeostasis
… in whole-body changes in fuel usage, from glucose to fatty acids, driven predominantly via insulin signaling defects in skeletal muscle. This metabolic shift is executed via engagement of the hypothalamic-pituitary-adrenal axis, and impairment of this process via silencing of …
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Regulation of glucose homeostasis by MUNC18c and syntaxin 4
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Dietary Protein Regulation of Insulin Sensitivity and Glucose Homeostasis
Taken together, these data suggest that HPD, high in leucine, modifies glycemic control by reducing the regulatory role of insulin and peripheral disposal of dietary CHO and upregulating hepatic gluconeogenesis under fasted conditions.
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… effects of alterations in endotoxin levels on glucose metabolism are not understood. The goal of this study was to determine the effects of short-term and long-term increases in endotoxin of a low magnitude on insulin signaling in a human primary cell line as well as the effects of short-term …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… insulin and glucagon, leading to dysfunctional glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the predominantly Gαs-coupled glucagon-like peptide 1 receptor (GLP-1R), which is a class B G protein-coupled receptor (GPCR), to mediate glucose …
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Identifying key nodes in brain neural circuits controlling glucose homeostasis
… the most fundamental processes – maintenance of glucose homeostasis. The brain is constantly informed about the state of our internal environment and the external world; if a disruption occurs, it is able to coordinate physiological and behavioural responses to counterbalance it. This concept …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… mice. Oral administration of kaempferol improved glucose intolerance and insulin sensitivity, and this effect was associated with increased Glut4 and AMPKa expression in muscle and adipose tissues. Consistent with our findings from the in iii vitro study in C2C12 muscle cell line, these findings …
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The role of PYY in regulating energy balance and glucose homeostasis
… important role in regulating energy balance and glucose homeostasis in vivo. PYY knockout mice became obese with ageing or high-fat feeding linked to a hyperinsulinemic phenotype associated with hypersecretion of insulin from isolated pancreatic islets. These findings suggested that PYY …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
… systems, neutrophil adhesion/migration and glucose homeostasis. In the first part of my thesis, I investigated cytoskeletal dynamics controlled by the Rac-GEF Tiam1 in neutrophil adhesion/migration. We previously found a paradoxical increase in the adhesion of Tiam1–/– neutrophils …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
… 5 months (mo) improved insulin sensitivity and glucose tolerances, which were associated with increased Glut4 and AMPKα expression in muscle and adipose tissues in middle-aged mice fed a high-fat (HF) diet. In vitro, kaempferol increased lipolysis and restored chronic high fatty acid-impaired …
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Molecular Mechanisms by which a Grape Seed Procyanidin Extract Modulates Glucose Homeostasis
… resulted in 5.1 million deaths in 2013. Blood glucose levels are tightly regulated in order to maintain metabolic homeostasis. The hormone insulin, after binding to the insulin receptor, initiates a well-established controlled metabolic signaling cascade that consequently lowers blood glucose …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
… the thermogenic capacity and insulin-stimulated glucose uptake in adipocytes, whereas PREX2 was reported to mediate glucose tolerance, possibly through its adaptor function as an inhibitor of the tumour suppressor PTEN. The aims of this project were to explore the importance of PREX proteins in …
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The upper small intestinal microbiota regulates nutrient sensing pathways to influence glucose homeostasis
… which is characterized by a dysregulation in glucose homeostasis. The microbiota within the gastrointestinal tract has been suggested to play a role in glucose regulation. However, the majority of work to date has focused on the distal intestinal microbiota despite the fact that the upper …
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Proportional-integral control in the evaluation of glucose homeostasis and Type 2 Diabetes
… to find parameter values that yield plausible glucose behaviour. These hormone measurements require repeated blood tests and limit the feasibility of applying the model to “real world” medical applications such as disease diagnosis. We apply a proportional-integral control model to human …
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dLipin-A Link between Lipid Metabolism, Glucose Homeostasis and Growth in Drosophila melanogaster
… two biochemical functions of Lipin and metabolic homeostasis. I discovered there is a strong interconnection between TAG synthesis and insulin pathway activity. Reduced activity of dLipin and other enzymes involved in TAG synthesis disrupted insulin pathway activity by interfereing with …
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P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis
… Prex2-/- mice are intolerant to insulin and glucose, and have reduced PI3K signaling in the fat and liver following insulin stimulation. Furthermore, the activity of PTEN from Prex2-/- liver samples is elevated, and correlated with a decrease in cellular PIP3 levels. After uncovering an …
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Defective branched chain amino acid catabolism impairs exercise capacity and glucose homeostasis in the mouse
… metabolism; the role of BCAAs in regulating glucose and fatty acid utilization in skeletal muscle, the role of downstream intermediates on tricarboxylic acid (TCA) cycle flux during exercise, and the impact of elevated BCAAs on gluconeogenesis during exhaustive exercise. We found that …
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GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY
… a wide variety of biomedical pathways, including glucose homeostasis and energy metabolism.
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Chickens from lines artificially selected for juvenile low and high body weight differ in glucose homeostasis and pancreas physiology
… hyperglycemic, displaying fasting blood glucose concentrations twice that of a normal human. While circulating levels of insulin are similar in avians and mammals, and structure and function of the insulin receptor are also conserved among vertebrate species, birds do not experience …
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