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Showing 1 to 20 of 44 for “"glucose deprivation"”.

  1. Neuroprotective Effects of Propofol and Ketamine(alone or combined) Against Oxygen-Glucose Deprivation-Reperfusion Injury

    최, 정웅2011

    "허혈-재관류 뇌손상에 대한 Propofol, Ketamine 단독 혹은 혼합 투여의 효과 연구 목적 : Propofol 과 ketamine 은 뇌보호 작용이 있는 것으로 알려져 있으나, 이들 두 약제를 동시에 사용하는 것이 뇌보호 작용에 어떤 효과가 있는지에 대하여는 잘 알려져 있지 않다. 본 실험연구는 propofol 과 ketamine 을 같이 사용하는 것이 허혈-재관류로 인한 뇌손상으로 부터 뇌세포를 보호하는데 부가적인 효과가 있는지 알아보기 위하여 시행하였다. 연구 방법 : 13일째 혼합 배양된 세포를 무산소, 무포도당 …

    ajou Repository record

  2. Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations

    Saggese, TarynResearchSpace@Auckland2016

    … initiated by mechanical stress and/or nutrient deprivation. This study aimed to investigate the phenotypic and functional differences between NC and MNP cells in response to a range of hydrostatic pressures and glucose concentrations. In this study a novel isolation method was developed that …

    auckland-ms Repository record

  3. Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma

    Aldarwesh, AmalUniversity of East Anglia2015

    … insults, specifically oxygen and/or glucose deprivation (OGD) on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different …

    east-anglia Repository record

  4. The Influence of Propofol Administration Time on Oxygen Glucose Deprivation-Reperfusion Injury in Rat mixed Cortical Cultures Focused on N-Methyl-D-Aspartate (NMDA) Receptor

    김, 은진2011

    … cultures were exposed to a 5 min combined oxygen glucose deprivation(OGD, in vitro ischemia model), followed by 2 hr reoxygenation(reperfusion). Propofol (1, 10 25, 50, 100 μM) were treated from 1 hr prior to the OGD injury (pre-treatment)or from the initiation of the OGD injury(co-treatment) to …

    ajou Repository record

  5. The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis

    Han, Fei2017

    … Akt activation, Glut1 expression, and glucose uptake. AMPK is also required for various stresses induced Akt activation and promote cell survival, including hypoxia and glucose deprivation. In addition, we found glucose deprivation-induced VEGF expression and secretion is also depend on …

    uthsc Repository record

  6. The regulation of CD8+ T cells by nutrient availability

    Youdale, TomUniversity of Dundee2021

    … dependent on the availability of extracellular glucose and amino acids. We established that T cells switch off autophagy when they respond to immune activation and increase amino acid transport: they revert to autophagy when their capacity for amino acid transport is low. Effector CD8+ cytotoxic …

    dundee Repository record

  7. Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion

    Kearon, Joanne2014

    … metabolic challenge would cause neuronal damage. Glucose deprivation, hypoxia and treatment with an electron transport chain (ETC) uncoupler caused neuron loss and axonal damage in in vitro co-cultures of myenteric neurons, intestinal smooth muscle cells and glia. Furthermore, we investigated the …

    queens Repository record

  8. Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones

    Smith, Andrew JohnUniversity of Glasgow2008

    … 3-nitropropionic acid and oxygen-glucose deprivation. Additionally, extensive study was carried out of the actions of increased glucose concentration and a range of metabolites of the essential amino acid tryptophan. It was demonstrated that several tryptophan metabolites induced …

    glasgow Repository record

  9. Development of a protocol to examine red blood cell functional adaptations to intermittent hypoxia

    Ruzgys, TaylorUniversity of Ontario Institute of Technology2025

    … variable and integrates in vitro stress testing (glucose deprivation, oxidative stress, hyperthermia) to evaluate RBC vulnerability, demonstrated by phosphatidylserine externalization, intracellular calcium accumulation, and reactive oxygen species generation indicating premature damage and cell …

    uoit Repository record

  10. The growth-arrest-specific protein gas7 potentiates neuronal differentiation

    Lortie, KarineUniversity of Ottawa (Canada)2013

    … not protect against toxicity triggered by oxygen-glucose deprivation, the calcium ionophore A23187 or sodium nitroprusside. The ability of gas7 to potentiate neuritogenesis and neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in …

    ottawa-retro Repository record

  11. Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke

    Madineni, AnushaUniversity of Toledo Health Science Campus2013

    … ischemic models such as oxidative stress, oxygen glucose deprivation (OGD) in vitro and permanent middle cerebral artery occlusion (pMCAO) in vivo were used. The expression profile studies by immunoblotting and fluorescence methods displayed decrease in phosphocofilin (inactive form of cofilin) …

    ohiolink Repository record

  12. Astrocytes down-regulate microglial inflammatory responses

    김, 종현2011

    … activation. Astrocytes were treated with oxygen-glucose deprivation (OGD) or hydrogen peroxide (H₂O₂, 0.01-1 mM), and culture conditioned media (OGDACM or H₂O₂-ACM) were collected. Both OGD-ACM and H₂O₂-ACM collected within 3 h after the treatment strongly reduced iNOS, COX-2, TNF-alpha, and IL-6 …

    ajou Repository record

  13. Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model

    김, 미경2011

    … proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate to the brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, many of the grafted hNSCs …

    ajou Repository record

  14. Protein structure and interaction under environmental stress : from quality control recognition to evolution of collective behavior

    Brock, Kelly PaigeMassachusetts Institute of Technology2016

    … global level, a budding yeast cell undergoing glucose deprivation both acidifies its cytosol and exhibits widespread protein clustering. By employing a proteome-wide computational assay, I examine how this drop in pH could lead to the formation of higher order protein structures. This modeling …

    mit Repository record

  15. Effect of sinusoidal extremely low-frequency electromagnetic stimulation on neurons and glia in a transient stroke model

    MOYA GOMEZ, Amanda2029

    … hippocampal cultures submitted to oxygen and glucose deprivation, but not in monocultures. Furthermore, in vitro studies showed that ELF-EMS did not affect proliferation but decreased lipopolysaccharide and ATP-induced microglia migration, possibly by targeting subcellular pathways involving …

    hasselt Repository record

  16. Testing the Gliocentric Hypothesis of Brain Pathology

    Ellwood, Sarah Hannah2019

    … Ischaemia was modelled using oxygen glucose deprivation (OGD). It was determined that astrocytes display regional differences in sensitivity to ischaemic insult. The most sensitive region was the dentate gyrus (DG), and corpus callosum (CC) was the least sensitive. Mature …

    plymouth Repository record

  17. The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia

    Rau, Thomas Fredrick

    … with 5mM LCAR for 2 hours prior to oxygen glucose deprivation (OGD). Under the same conditions we observed an LCAR induced decrease in both necrosis and mitochondrially-mediated apoptosis. To elucidate the mechanism for these data we studied the effect of LCAR on reactive oxygen species …

    montana-tech Repository record

  18. The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia

    Rau, Thomas Fredrick

    … with 5mM LCAR for 2 hours prior to oxygen glucose deprivation (OGD). Under the same conditions we observed an LCAR induced decrease in both necrosis and mitochondrially-mediated apoptosis. To elucidate the mechanism for these data we studied the effect of LCAR on reactive oxygen species …

    montana Repository record

  19. Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema

    Souvenir, Rhonda Andrea

    … were elucidated in vitro using oxygen and glucose deprivation to mimic hypoxia ischemia. Our findings showed that EPO treatment resulted in an upregulation of tissues inhibitor of matrix metalloproteinase (TIMP)-1 and inhibition of hypoxia inducible factor (HIF-1α) both of which …

    loma-linda Repository record

  20. Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD

    Wood, K. L.University of Dundee2017

    … with cellular Nrf2 status: Maximal response to glucose deprivation occurred at 4 hours in both WT and Nrf2<sup>-/-</sup> cells, but occurred at 6hours in cells with increased Nrf2 availability. The magnitude of the response was smaller in Nrf2<sup>-/-</sup> cells, suggesting that …

    dundee Repository record

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