Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"glucose and lipid metabolism"”.
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Adiponectin and Toll-Like Receptor 4: Important Adipocyte Modulators of Systemic Glucose and Lipid Metabolism
As a global epidemic, the prevalence of obesity and its complications have increased rapidly over the past few decades. Obesity, characterized by excessive amount of body fat accumulation, is a strong predictor to various major health conditions such as type 2 diabetes and cardiovascular disease. …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… followed by higher energy in close-up period; and 2) to evaluate the effect of monensin (M) supplementation to these two different diets on bovine hepatic mRNA expression of enzymes involved in liver adaptive mechanisms during the transition period. The treatments were arranged in a 2 …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
Obesity and diabetes are clearly established independent risk factors for renal disease. Therapeutic targets have been investigated for their role in treating obesity and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
Glucose and lipid metabolism are dysregulated in obese horses. Altered glucose metabolism is evidenced by the development of insulin resistance and increased fasting plasma insulin concentrations (hyperinsulinemia) while altered lipid metabolism is evidenced by increased plasma lipid …
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Engineering in vitro models of non-alcoholic fatty liver disease
Decreased resources and a scarcity of affordable, healthy food is contributing to rising obesity rates throughout the world. Consequentially, non-alcoholic fatty liver disease (NAFLD), which is highly correlated with obesity, rates are also increasing with greater than 30% of the US population …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown physiological roles for the AhR in normal liver growth and development, insulin …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… the second most diagnosed cancer type in women and is responsible for approximately 13% of cancer-related mortalities. Significant advances have been made in breast cancer therapy to date. However, the development of targeted therapies remains essential to overcome the lack of treatment options …
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Influence of Weight Loss on Metabolic and Mitochondrial Function in the Mature Horse
… issues in the horse, yet stepwise alterations in glucose and lipid metabolism, mitochondrial capacity and oxidant status during weight loss have yet to be analyzed. Skeletal muscle contains subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria, which respond differently to physiological …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin …
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Exploring the Multifaceted Life of Beige Adipocytes
… is closely linked to a range of chronic diseases and contributes significantly to morbidity and mortality worldwide. Adipose tissue lies at the center of this issue. However, it is increasingly recognized that it is the quality of fat, rather than its quantity alone, that has a greater impact on …
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Blood glucose and plasma lipids of Zucker fatty and lean rats fed diets containing cornstarch and sucrose
… effects of consumption of diets high in sucrose and cornstarch on glucose and lipid metabolism in Zucker fatty and lean rats and Sprague-Dawley rats were investigated in the present study. Rats of each strain or genotype, 8 to 10 months of age, were fed diets containing 56% cornstarch or 57% …
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Muscle disorder or metabolic disorder: genomic, transcriptomic, and metabolomic insights into the pathogenesis of wooden breast and white striping in commercial broiler chickens
… such as rapid growth, high breast muscle yield, and low feed utilization. One of the unintended consequences of such selection among modern broiler chickens has been the relatively recent emergence of several muscle disorders mainly affecting the pectoralis major muscle and severely impacting …
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Effects of naringenin on glucose uptake in L6 skeletal muscle cells
… is a disorder of inadequate insulin action and consequent high blood glucose levels. Type 2 diabetes accounts for the majority of cases of the disease and is characterized by insulin resistance and relative insulin deficiency resulting in metabolic deregulation. It is a complex disorder to …
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Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows
… dairy cows undergo extensive changes in metabolism and experience immune system adaptations which can hinder short-term health, production, and longevity. Various prepartum nutritional strategies have been implemented to alleviate negative consequences and maximize benefits to both cow …
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The role of macrophage intracellular lipid partitioning in glucose and lipid homeostasis during obesity
… most prevalent causes of death worldwide. Understanding how obesity leads to the development of the Metabolic Syndrome (MetS) and cardiovascular disease (CVD) will enable the development of novel therapies that dissociate obesity from its cardiometabolic complications. Our laboratory views the …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
… conditions such as light-dark cycles and to manage the optimal timing for cyclical physiological processes, including sleep-wakefulness, fasting-feeding and multiple aspects of metabolism. The circadian timing system is arranged in hierarchical fashion, with the master clock in the …
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Investigations on extra- and intracellular retinol-binding proteins
… immune system but also for cell differentiation and proliferation. Recently, ROH itself has been reported to be involved in adipogenesis and a ROH transport protein, the retinol-binding protein 4 (RBP4), in insulin resistance and type 2 diabetes. However, there is still considerable scientific …