Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"glucocorticoids"”.
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Glucocorticoids and angiogenesis
… series of interactions and is tightly regulated. Glucocorticoids are acknowledged to inhibit angiogenesis at high concentrations but whether endogenous glucocorticoid concentrations are sufficient to regulate angiogenesis is unclear. Adrenal synthesis is not the sole determinant of glucocorticoid …
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The impact of glucocorticoids upon the insulin sensitivity of skeletal muscle
Glucocorticoid (GC) excess is characterised by central obesity, hypertension, proximal myopathy, insulin resistance and in some cases overt type 2 diabetes (T2D). However, the precise molecular mechanisms responsible for these observation have not been defined in detail. We have shown that GCs …
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Cellular clocks on steroids: the mechanism of circadian entrainment by glucocorticoids
Throughout the tree of life most organisms exhibit circadian rhythms to optimize the efficiency of their biological processes and behaviours in light of daily fluctuations in Earth’s environmental conditions. In mammals, glucocorticoid (GC) steroid hormones are vital for signalling time-of-day …
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Gene expression profiling reveals novel actions of glucocorticoids on immune cells during inflammation
… is further modulated upon administration of glucocorticoids (GC). In total, more than 350 genes/ESTs were identified as being induced or repressed by LPS, whereas 106 (30) of them responded to GC treatment. The molecular mechanisms of GC action on the expression of LPS induced or repressed …
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Intergenerational effects of early life programming: the role of glucocorticoids and maternal obesity
Hypertension and type two diabetes mellitus (Type 2 DM) are serious chronic illnesses that impact on the lives of millions of people around the world. Various epidemiological studies have shown a relationship between early life events such as intrauterine growth retardation (IUGR) resulting in low …
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Transgenerational Effects of Synthetic Glucocorticoids on Offspring Behaviour and HPA Development in Guinea Pigs
Glucocorticoids are essential for fetal maturation. However, exposure to high levels of glucocorticoids (i.e. maternal stress/anxiety or synthetic glucocorticoid treatment [sGC]) alters the trajectory of development and increases the risk for chronic diseases later in life. Approximately 10% of …
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Sarcopenia and cognitive ageing: investigating their interrelationship, biological correlates and the role of glucocorticoids
… statistical modelling to investigate the role of glucocorticoids in sarcopenia; and an invasive clinical study to develop a novel technique to measure the activity of 11beta-hydroxysteroid dehydrogenase (11βHSD1) in the human brain in vivo. Results I consistently found a relationship between: some …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… in fetal cortisol and that exposure to synthetic glucocorticoids in premature offspring could accelerate pulmonary maturation, reducing risk of respiratory complications. Ante- and post-natal glucocorticoid therapy has since been demonstrated to significantly reduce morbidity and mortality in the …
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Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
Acute lymphoblastic leukemia (ALL) is the most frequent cancer in children, and although highly treatable, challenges remain due to significant side effects of therapy and the poor outcome for some patients. Synthetic glucocorticoid, Dexamethasone (Dex), has been used to treat several …
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Identification of the cellular mechanisms undelying the contribution of stress and glucocorticoids to Alzheimer's disease pathology
… evidence suggests the involvement of stress and glucocorticoids (GC) in the etiopathogenesis of Alzheimer’s disease (AD), a disease marked by severe memory impairments as well as alterations in mood and emotional state. The experiments described in this dissertation represent an attempt to …
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Association of Maternal Cumulative Risk during Pregnancy and IQ in Preschoolers: Role of Glucocorticoids and their Receptors
There may be a cumulative effect of social and environmental risk factors which lead to chronic, elevated levels of stress. Constant elevations of maternal stress hormones during pregnancy disrupt developing fetal brain chemistry and architecture, resulting in later memory and learning …
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The regulation of the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) by glucocorticoids and progestins
Estradiol (E2) plays a crucial role in female reproduction and in the defense against HIV-1 in the female genital tract (FGT). Medroxyprogesterone acetate (MPA) intramuscular (DMPA-IM) (Depo-Provera) and norethisterone (NET) enanthate (NET-EN) are injectable progestin only contraceptives. DMPA-IM …
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In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids
The degradation of articular cartilage is the hallmark in the pathogenesis of osteoarthritis (OA). It still remains largely unknown which precise mechanisms initiate cartilage degradation. However, risks factors include traumatic joint injury that results in immediate upregulation of inflammatory …
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Investigation of the cellular and physiological effects of 5 alpha-tetrahydro reduced glucocorticoids in vitro and in vivo
Glucocorticoids have been the most widely used anti-inflammatory drugs. However, chronic excessive exposure to glucocorticoids causes numerous side effects, including obesity, hypertension and type II diabetes. Thus dissociated steroids with anti-inflammatory efficacy and reduced metabolic side …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… in human pathology. These effects of stress and glucocorticoids have been associated with the onset and exacerbation of neuropsychiatric disorders.In previous studies we found that acute footshock (FS)-stress induces an increase of glutamate release from synaptosomes of prefrontal and frontal …
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The Effect of Phosphodiesterase Inhibitors on the Induction of Gene Expression by Long-Acting beta2-Adrenoceptor Agonists and Glucocorticoids
Recently, phosphodiesterases (PDE)4 inhibitors have received approval as a complementary anti-inflammatory treatment for chronic obstructive pulmonary disease (COPD) patients who are already taking long-acting β2-agonists (LABA)/inhaled corticosteroid (ICS) combination therapy. However, this …
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