Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"glucocorticoid receptors"”.
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… Although TNBC lacks estrogen and progesterone receptors, 15-40% of TNBC patients express the glucocorticoid receptor (GR). Women with TNBC that express high levels of GR have poor outcomes. We hypothesize that GR is a key mediator of advanced cancer phenotypes in TNBC. Altered signaling …
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Characterization of estrogen and glucocorticoid receptors, skeletal muscle protein turnover and tissue growth in lambs treated with trenbolone acetate and estradiol
… (E2) implantation on the characteristics of the glucocorticoid and E2 receptor, skeletal muscle protein turnover and tissue growth. Twenty-four lambs were utilized. Trenbolone acetate did not ,affect (P>.10) degradation rates in the semitendinosus (ST) and triceps brachii (TB) muscles, the …
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Colostrum feeding and its effects on serum cortisol, thyroxine, immunoglobulin G and cytosolic glucocorticoid receptors in skeletal muscle in the bovine neonate
… of the ligands tested had an affinity for the glucocorticoid receptor. The percent of specific binding for each was: dexamethasone (66+/-14), corticosterone (52+/-10), cortisol (58+/-13), estradiol-17, beta (37+/-7), progesterone (29+/-9), testosterone (10+/-3), and triamcinolone (41+/-11).
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Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (taeniopygia Guttata)
… of corticotropin releasing hormone and glucocorticoid receptors, social preference and pair bonding using a model species uniquely suited to studying long-term, monogamous relationships.</p>
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Reciprocal Relationships Between the Neuroendocrine System and Lymphoid Cells
… results in increased plasma concentrations of glucocorticoids and cathecholamines. Lymphoid cells possess receptors for both of these stress-related hormones, and activation of these receptors affects functional activities of lymphoid cells. In the present experiments, it is demonstrated that …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… the peripheral nervous system. Progesterone and glucocorticoids were found to increase the rate of myelin synthesis in a dose-dependent manner. Both steroids increased the expression levels of myelin glycoprotein Po and the number of myelin internodes in treated co-cultures. It was discovered …
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Increasing Complexity of an Hypothalamus-Pituitary-Adrenal Axis Mathematical Model with Predictive Applications and Physiological Implications
… with negative feedback into the system from glucocorticoid receptors elicits the observed ultradian oscillations in humans. Additionally, simulations of increased hypothalamic monitoring and control of cortisol concentrations create a natural oscillation within the desired period. Results …
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Glucocorticoid resistance in COPD patients and lung cancer
… surrounding microenvironment in the lung tissue. Glucocorticoids are the main treatment for many inflammatory diseases, however, the majority of COPD patients are resistant to glucocorticoids, so a better understanding of the exact mechanism of glucocorticoid resistance in COPD patients and lung …
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Cognitive, neuroanatomical and neuroendocrine effects of long-term rotating shift work in a nursing sample
… hippocampus, which has a high concentration of glucocorticoid receptors and plays a prominent role in the down-regulation of the HPA axis. Overstimulation of glucocortioid receptors can cause hippocampal atrophy and related cognitive deficits. Research has found that air crew with inadequate …
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The Role of Microglia in the Effects of Steroid Hormones on Brain Inflammation
… mice in vivo. The expression of steroid hormone receptors was studied as well as their function. This dissertation shows that microglia cells are not direct targets of estrogen actions, but respond profoundly to glucocorticoids, which exert anti-inflammatory effects on the production of cytokines …
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Effects of urbanization on the physiology, behavior, and fitness of a wild songbird
… I investigated urban birds' termination of the glucocorticoid stress response by looking at their ability to reduce circulating levels of glucocorticoid 'stress' hormones and the relative abundance of receptors that provide negative feedback in the hippocampus and hypothalamus. I found that …
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Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… treatment altered the expression of synaptic receptors containing α1/α4/γ2 subunits as well as phasic currents. The changes in the expression and function of GABAARs, induced by neonatal estradiol treatment, may not be related to the fluctuations in allopregnanolone concentrations, given that …
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Identification of the cellular mechanisms undelying the contribution of stress and glucocorticoids to Alzheimer's disease pathology
… evidence suggests the involvement of stress and glucocorticoids (GC) in the etiopathogenesis of Alzheimer’s disease (AD), a disease marked by severe memory impairments as well as alterations in mood and emotional state. The experiments described in this dissertation represent an attempt to …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… areas and mRNA and protein levels of glutamate receptors are changed in brain areas. A number of preclinical studies on animal models of MADI have shown that different types of environmental stress and glucocorticoid administration affect glutamate transmission and exert structural brain …
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Intergenerational and Transgenerational Effects of Endocrine Insults
… endocrine disrupting chemicals (EDCs), synthetic glucocorticoids (sGCs), and hyperthyroidism – in two different species, humans and mice. EDCs are exogenous substances that interfere with endocrine axes to cause adverse health effects. Humans are ubiquitously exposed to EDCs and recent animal …
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Alterazioni indotte dall'isolamento sociale sulla regolazione a feedback negativo dell'asse ipotalamo-ipofisi-surrene
… that act as positive modulators at GABAA receptors. Moreover, social deprivation is accompanied by an enhanced neurosteroidogenesis in response to acute stressful stimuli and it increases the sensitivity of the pituitary to corticotropin-releasing factor (CRF). Furthermore, the …
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The role of ventromedial and dorsolateral prefrontal cortex in physiological and behavioural dysfunction in non-human primates, of relevance to mood and anxiety disorders
… area 25 expresses both mineralocorticoid and glucocorticoid receptors, which suggests elevated cortisol can directly modulate activity in this region. Three subsections investigating the above, form three chapters of this thesis. Chapter three focuses on the effect of overactivation and …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… Various factors such as an increase in number of glucocorticoid receptors β, increase in activator protein-1 (AP-1), and increase in Th-2 cytokines (IL-4 and IL-13), and diminished histone deacetylase-2 activity are attributed to corticosteroid resistance. Since smoking is the primary risk factor …
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Methamphetamine and amphetamine differentially affect associative learning: behavioral and neurobiological correlates
… how specific neurobiological mechanisms, namely glucocorticoid or dopamine receptor activation, contribute to these alterations. A second goal was to investigate potential differences in the effects of two psychostimulants; methamphetamine (METH) and amphetamine (AMPH). These drugs were chosen …
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A TALE OF TWO STRESS MODULATORS: EFFECT OF DELTA OPIOID RECEPTOR AGONISM AND FKBP5 INHIBITION ON GENE EXPRESSION AND BEHAVIOR DURING COCAINE WITHDRAWAL
… stress system, which triggers the release of glucocorticoids from the adrenal cortex. The HPA axis is governed by a negative feedback system where released glucocorticoids inhibit the axis by binding to their own glucocorticoid receptors (GR). FKBP5 is a co-chaperone of the GR complex that …
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