Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"glucocorticoid receptor"”.
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Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
… by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) signalling. It has been found that early life events can affect epigenetic programming of GR, and methylation of the GR promoter has been reported in colorectal tumourigenesis. Decreased GR expression has also been …
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Inquiries into the subcellular localization of the glucocorticoid receptor.
In the absence of hormone, the glucocorticoid receptor (GR) resides in the cytoplasm existing in an inactive form complexed to heat shock proteins and immunophilins. Upon ligand addition, GR dissociates from the protein complex and transforms into an active free form that rapidly and completely …
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Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
The purpose of this paper is to characterize the glucocorticoid receptor (GR) signaling and relevance in the context of enzalutamide resistant prostate cancer cells. Enzalutamide is a drug that functions to dampen androgen receptor (AR) signaling, thus inhibiting cancer dependency on the receptor …
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Binding sites in the nuclear envelope for cytoplasmic glucocorticoid receptor complex
… cytoplasmic triamcinolone acetonide-receptor complex has been purified 3 000 fold from rat liver cytosol. The isolated complex sedimented as a single radioactive peak on a 5 - 20% sucrose gradient. Nuclear envelopes isolated from purified rat liver nuclei were found to contain binding …
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Antiretroviral drugs differentially modulate glucocorticoid activity via the glucocorticoid receptor in vitro
… is widespread. During times of stress and during glucocorticoid (GC) therapy, intracellular ARVs are in the presence of high concentrations of GCs, which regulate all aspects of immunity and inflammation via the glucocorticoid receptor (GR). However, the reciprocal modulation of ARV and steroid …
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CHARACTERIZATION OF THE GLUCOCORTICOID RECEPTOR IN MOUSE MAMMARY GLAND DURING PREGNANCY AND LACTATION.
CHARACTERIZATION OF THE GLUCOCORTICOID RECEPTOR IN MOUSE MAMMARY GLAND DURING PREGNANCY AND LACTATION.
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Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor
… has not been determined via their target steroid receptor (SR), the progesterone receptors and its isoforms (PR-A and PR-B). This thesis involves an in vitro investigation of some of the factors that affect PR activity and that may thus impact progestogen responses in women on HC or HRT. These …
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… studies have described ligand-independent glucocorticoid receptor (GR) activation in which non-steroidal ligands are able to activate the GR in the absence of glucocorticoids. This study investigates the regulatory effects of epidermal growth factor (EGF) on cytokine gene expression in …
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Glucocorticoid Receptor Density and Binding Affinity in Horses with Systemic Inflammatory Response Syndrome
… fluorochromes could be used to determine the glucocorticoid receptor (GR) density and binding affinity (BA) in equine peripheral blood mononuclear cells. The second was to determine if there was a correlation between elevated plasma cortisol and GR density or binding affinity in healthy adult …
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Effects of site specific phosphorylation on the structure and functions of the glucocorticoid receptor
… transcription factors, like nuclear hormone receptors (NHRs), are capable of exerting transcriptional regulation in the nucleus in response to various intra- and extracellular signals. Transcription factors contain segments that are intrinsically disordered (ID) under native conditions. …
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Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status alone is insufficient to predict treatment response. As a result, additional …
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The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells
Glucocorticoids (GCs) play important functions in human physiology, and are commonly prescribed anti-inflammatory and immunosuppressive drugs. GCs are used in treatment of childhood acute lymphocytic leukemia (ALL), however resistance to therapy and side effects highlight the need for further …
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The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH …
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An investigation into the role of acetylation and ligand-dependent nuclear localisation in glucocorticoid receptor transcriptional regulation
The glucocorticoid receptor (GR) is a ligand-activated transcription factor which, due to its central role in anti-inflammatory responses, is a target of many therapeutically prescribed drugs. The GR undergoes multiple post-translational modifications, including phosphorylation and acetylation; …
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Cross talk between the glucocorticoid receptor and the progesterone receptor in modulation of progestin responses and HIV-1 infection
… MPA has been shown to activate both the glucocorticoid receptor (GR) and its target, the progesterone receptor (PR) isoform B (PR-B), which are both transcription factors and regulate genes involved in immune function. Both the GR and PR are expressed in the cervix, the primary site of …
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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
… of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for the effects of stress on reproduction. The present study investigated whether this crosstalk between the GR and GnRHR …
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Synergism between immune activators and progestogens: differential effects on gene expression and HIV-1 replication and the role of the glucocorticoid receptor
… (TNF) and lipopolysaccharide (LPS)] via the glucocorticoid receptor (GR) regulate the expression of genes of relevant for maintaining the integrity of genital tract mucosal surfaces, mucosal permeability, select immune function genes and HIV-1 replication. This hypothesis was investigated in …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… the highest mortality rate in childhood cancer. Glucocorticoids (GCs) have been used as chemotherapeutic drugs for children with ALL for more than 50 years. GCs induce apoptosis in lymphoid cells. However, little is known about the molecular mechanism of GC-induced apoptosis and there are many …
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