Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 303 for “"glucocorticoid"”.
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Antiretroviral drugs differentially modulate glucocorticoid activity via the glucocorticoid receptor in vitro
… is widespread. During times of stress and during glucocorticoid (GC) therapy, intracellular ARVs are in the presence of high concentrations of GCs, which regulate all aspects of immunity and inflammation via the glucocorticoid receptor (GR). However, the reciprocal modulation of ARV and steroid …
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ETHANOL REGULATION OF GLUCOCORTICOID RESPONSIVE GENES
Glucocorticoid hormones modulate acute and chronic behavioral and molecular responses to drugs of abuse including psychostimulants and opioids. Acute ethanol activates the hypothalamic pituitary adrenal (HPA) axis causing the release of adrenal glucocorticoid hormones, but following chronic ethanol …
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Liposomal targeting of glucocorticoid in experimental arthritis
Contains fulltext : 108521.pdf (Publisher’s version ) (Open Access)
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Glucocorticoid resistance in COPD patients and lung cancer
… surrounding microenvironment in the lung tissue. Glucocorticoids are the main treatment for many inflammatory diseases, however, the majority of COPD patients are resistant to glucocorticoids, so a better understanding of the exact mechanism of glucocorticoid resistance in COPD patients and lung …
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Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
… by the HPA axis in the brain and is mediated by glucocorticoid receptor (GR) signalling. It has been found that early life events can affect epigenetic programming of GR, and methylation of the GR promoter has been reported in colorectal tumourigenesis. Decreased GR expression has also been …
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Inquiries into the subcellular localization of the glucocorticoid receptor.
In the absence of hormone, the glucocorticoid receptor (GR) resides in the cytoplasm existing in an inactive form complexed to heat shock proteins and immunophilins. Upon ligand addition, GR dissociates from the protein complex and transforms into an active free form that rapidly and completely …
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Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
The purpose of this paper is to characterize the glucocorticoid receptor (GR) signaling and relevance in the context of enzalutamide resistant prostate cancer cells. Enzalutamide is a drug that functions to dampen androgen receptor (AR) signaling, thus inhibiting cancer dependency on the receptor …
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Characterization of glucocorticoid metabolism by microbial steroid-17,20-desmolase
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… the highest mortality rate in childhood cancer. Glucocorticoids (GCs) have been used as chemotherapeutic drugs for children with ALL for more than 50 years. GCs induce apoptosis in lymphoid cells. However, little is known about the molecular mechanism of GC-induced apoptosis and there are many …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… die from the disease than other ethnic groups. Glucocorticoid signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. The mechanism involves glucocorticoids binding to glucocorticoid receptor (GR) and …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
Since the introduction of glucocorticoids (GCs) in the treatment of rheumatoid arthritis in 1949, GC therapy has been associated with a number of adverse effects. Long-term use of GCs can result in growth retardation during childhood due to their actions on growth plate chondrocytes, although the …
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Towards an understanding of synthetic glucocorticoid hazards in aquatic systems.
Synthetic glucocorticoids are pharmaceutical compounds that mimic cortisol, the endogenous ligand ubiquitous to vertebrates and bind to the glucocorticoid receptor within the cytoplasm. Here I examine occurrence of these endocrine disrupting contaminants of emerging concern in surface waters and …
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Effect of cellular zinc concentration on glucocorticoid induced gene expression
… a zinc deficit was created in cell cultures and glucocorticoid regulated and constitutive gene expression monitored. Using a cell impermeable zinc specific chelator, diethylenetriaminepentaacetic acid (DTPA), a zinc deficient state in HeLa cells was created. This deficit was quantified by a …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
… proinflammatory cytokines and chemokines. Glucocorticoids, being the most effective drugs for IBD patients, seem to have influence not only on the infiltrated inflammatory cells but also on epithelial cells. It is a clinical observation that about 20 % of IBD patients are resistant to …
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Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle
Older adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize …
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Induction of Alkaline Phosphatase Isoenzymes in Tissues of Glucocorticoid-Treated Dogs
Finally, the feasibility of an in vitro liver model for the study of ALP induction was explored and deemed selectively useful.
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Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
Glucocorticoids (GCs) are steroid hormones widely prescribed to treat inflammatory disorders and are regarded as anti-inflammatory molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory genes via its endogenous cell receptor; the glucocorticoid …
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Binding sites in the nuclear envelope for cytoplasmic glucocorticoid receptor complex
… The possibility that the envelope mediates the glucocorticoid response in ways not linked to transport of the cytoplasmic receptor complex into the nucleus cannot be ruled out.
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GENETIC ANALYSIS OF THE GLUCOCORTICOID PATHWAY IN THE SEVERE ASTHMA RESEARCH PROGRAM
Asthma is a common lung disease affecting approximately 10% of the population in the United States. Approximately 10% of the individuals with asthma have a severe form of asthma that is inherently difficult to treat due to a poor response to treatment, namely inhaled corticosteroids (ICS). …
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