Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 61 for “"glucagon-like peptide-1 (GLP-1)"”.
-
Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
$\textbf{Background}$ Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the …
-
The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… of Alzheimer's disease (AD), amyloid beta (Aβ)- peptides, are generated by sequential proteolysis of the amyloid precursor protein (APP) by β- and γ-secretase activities. Alternatively, APP can be processed nonamyloidogenically by an α-secretase activity that cleaves within the Aβ-domain, …
-
Hormone Responses to Two Different Energy Restriction Programs
There is a general decrease in satiety hormones (glucagon-like peptide 1 (GLP-1) and leptin) and an increase in hunger hormones (ghrelin) with weight loss, however results are conflicting. Currently, no studies have examined hormone levels comparing different approaches in calorie reductions for …
-
The individual and combined effects of whey protein and acute aerobic exercise on glycemic control
… on plasma glucose, insulin, gastric inhibitory peptide (GIP), glucagon like peptide 1 (GLP-1), and glucagon in normal, healthy men. Eleven males (mean ± SD age: 24.3 ± 5.4 years; BMI: 26.0 ± 5.3 kg/m2; HbA1c: 5.2 ± 0.2 %; VO2 max: 38.3 ± 6.1 ml/kg/min) completed four randomized trials consisting …
-
The Cardiovascular Effect of GLP-1 in Humans
The incretin glucagon-like peptide-1 (GLP-1) abolishes post-ischemic left ventricular contractility (stunning) in humans but the mechanism remains elusive. I hypothesized that this effect is mediated by peripheral or coronary vasodilatation. A comprehensive assessment of the haemodynamic effects of …
-
Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model
… Studies have shown that some flavanols increase glucagon-like peptide 1 (GLP- 1) levels. GLP-1 is a feeding hormone that increases insulin secretion after carbohydrate consumption and increased GLP-1 levels may be responsible for some of the beneficial effects on glycemic control after flavanol …
-
Controlled release of GLP-1 from affinity-based protein microspheres and quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by macrophages
Peptide drugs are highly specific and efficacious; interest in them remains high despite the challenges of rapid clearance and degradation. To overcome these limitations peptide delivery systems must prolong release while protecting biological activity. Glucagon-like peptide 1 (GLP-1) stimulates …
-
Impact of Physical Activity on Postprandial Lipidemia and Glycemic Control after Chronic Fructose Ingestion
… (TNF<em>-a</em>), interleukin-6 (IL-6), glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), c- peptide, glucose and insulin concentrations. Area under the curve (AUC) and absolute change from peak to baseline concentrations (Δ peak) were calculated to quantify …
-
Factors governing gastrointestinal motility
… causally relate alterations in GI motility and Glucagon like peptide -1 (GLP-1) with weight loss and resolution of DM following bariatric surgery.An interesting "spin off" result of my studies was validation of capsule endoscopy (CE) as a means of assessing GI motility.My results obtained from …
-
Identification of genipin as a potential treatment for type 2 diabetes
… decline of pancreatic β cells in T2D patients. Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by human intestinal L cells, which can stimulate the proliferation and differentiation of β cells and promote glucose-stimulated insulin secretion (GSIS), thereby playing a critical role …
-
Delayed gastric emptying in Ivor Lewis Gastro-oesophagectomy
… dilatation. Analyses of gut hormones(GH): glucagon-like-peptide-1(GLP-1) and peptide tyrosine tyrosine(PYY), were conducted based on DGE status and treatment. Post-operative DGE-related symptoms(PODRS) were assessed using a modified questionnaire. The algorithm had sensitivity of 100.0%, …
-
THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
… glucose-stimulated insulin secretion and glucagon-like peptide-1 (GLP-1) potentiated-insulin secretion. It is shown here that accurate regulation of ?-cell cAMP is necessary for adequate islet adaptation to a perturbed metabolic environment and protective for the development of glucose …
-
Thylakoid membranes from green plants affect appetite and promote body weight loss
… promoting hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), while decreasing levels of the hunger promoting hormone ghrelin. Moreover, circulating levels of leptin and blood lipids are decreased after thylakoid supplementation for two and three months. Finally, thylakoids …
-
G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from K-cells and L-cells respectively, augment insulin secretion. In addition, GIP facilitates triglyceride storage and GLP-1 has anorexic effects. Incretins are released from the …
-
Central mechanisms underlying the synergistic anorectic effect of CCK and GLP-1 combination therapy
… therapies that enhance the effects of separate peptides while limiting adverse effects constitute a promising strategy to improve the efficacy of pharmacologic-based treatments of diabetes and obesity. Cholecystokinin (CCK) and Glucagon-like peptide-1 (GLP-1) are gut hormones produced in …
-
The Effects of Acute Consumption and Chronic Supplementation of Cocoa on Overweight and Obese Adults at Risk of Developing Diabetes
… hours and were analyzed for glucose, insulin, C-peptide, glucagon-like peptide 1 (GLP-1), and gastric inhibitory peptide (GIP). Cocoa did not influence these measures. However, participants with the lowest fasting blood glucose concentrations were more likely to respond to the cocoa as …
-
THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… drugs such as metformin and drug targeting Glucagon-Like Peptide-1 (GLP-1) are being proposed for psychiatric and cognitive treatments, although their use for non-diabetic purposes remains debated. Methods: The role of antidiabetic drugs in ameliorating psychiatric and cognitive functions …
-
NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE: NUCLEOBINDIN-1/2-ENCODED INSULINOTROPIC AND ENTEROTROPIC PEPTIDES
… so far. In 2006, nesfatin-1, an 82 amino acid peptide encoded in NUCB2 was discovered. Nesfatin-1 is an anorexigenic and insulinotropic peptide found abundantly in hypothalamus, pancreas and stomach. Meal responsive insulin secretion is regulated by glucagon like peptide-1 (GLP-1), glucose …
-
Dietary resistant starch improved maternal glycemic control in Goto-Kakizaki rat
… body fat accumulation in rodents, increases GLP-1 at both the gene expression level and plasma levels, and improves glucose tolerance in STZ-induced diabetic mice. However, studies concerning dietary resistant starch and maternal hyperglycemia are scarce. In this project, we examined the …
-
Health Effects of Dietary Fermentable Fiber (Resistant Starch)
… with or without increased incretin hormone glucagon-like peptide 1 (GLP-1). Two main studies were performed. In the first main study, low potency antibiotics (Ampicillin 1g/L and Neomycin 0.5g/L) were added to the drinking water of rats to reduce fermentation of RS. Antibiotics were used …
Page 1 of 4