Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 203 for “"glucagon"”.
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Circadian Secretion of Glucagon-like Peptide-1
… metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has recently been shown to follow a circadian rhythm of secretion that parallels the expression of the core clock gene, Bmal1. However, …
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Chemical strategies for improving anti-diabetic glucagon therapy
… by producing hormones including insulin and glucagon which act on different cell types to affect blood glucose concentrations. Under certain conditions, the concentration of blood glucose falls below normal range. This will lead to several complications including death and must be treated …
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Regulation of glucagon secretion from pancreatic alpha cells
Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like …
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COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON
A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method …
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Studies on Solid-Phase Peptide Synthesis: The Synthesis of Glucagon
… studied in the synthesis of the peptide hormone glucagon. The choice of this molecule was based upon: (1) the unusual chemical structure; (2) biological significance. The main features of the strategy employed are: (1) the use of Biphenylisopropyloxycarbonyl group (Bpoc) for N<sup>α</sup>-amino …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… insulin available, but also excessive amounts of glucagon present. They were the first to provide evidence that hyperglucagonemia in type 2 diabetes mellitus may result from insulin resistant alpha-cells, since patients' circulating glucagon levels were poorly suppressed by exogenous insulin. …
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Insulin and Glucagon Responses to Dietary Protein in Diabetic and Nondiabetic Men
… in place of protein. Blood levels of insulin, glucagon, glucose and lipids were measured at fasting, one-half hour and two hours postprandial. To all meals, the nondiabetic subjects responded with a quick rise of the insulin level which decreased at two hours. In contrast, the diabetics showed …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
$\textbf{Background}$ Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the …
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Cardiovascular Effects of GLP-1 and Glucagon Dual Receptor Agonism in Humans
… including dipeptidyl peptidase IV inhibitors, glucagon like peptide-1 (GLP-1) receptor agonists and selective sodium-glucose transporter-2 inhibitors (SGLT2i). These medications have transformed treatment pathways and prognosis for individuals with T2DM as well as obesity (GLP-1 receptor …
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Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
… great challenge to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a hormone that is used in the treatment of type-2 diabetes. However, GLP-1 has a short half-life *in vivo* and it is prone to aggregate which complicates its pharmaceutical usage. Strategies to overcome the short …
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The Effects of a Protein Sparing Modified Fast on Insulin and Glucagon Levels
… protein, 75% glucose. The hormonal response of glucagon and insulin relative to the four diets was evaluated. Baseline and post-fast serum samples were obtained from the subjects.</p> <p>Analysis showed no significant difference in response elicited by the various diets of either insulin or …
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Glucose tolerance, plasma insulin, and plasma glucagon in relation to obesity in chickens
… glucose tolerance, plasma insulin, and plasma glucagon were examined in chicks developed through selection for high (HW) and low (LW) body weight, and in F, crosses (HL) between HW males and LW females. At 21, 42, 63, and 84 days of age, chicks from each population were intubated with glucose …
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The binding and activation of the glucagon-like peptide-1 receptor by exendin-4
… (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus. The two peptides mediate their functions through coupling to the glucagon like peptide-1 receptor (GLP-1R) with similar …
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The effect of guanine nucleotides on glucagon-sensitive adenylate cyclase in the rat heart
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Radioimmunoassay of insulin and glucagon with studies on the obese hyperglycaemic syndrome in mice
… and precise radioimmunoassays for insulin and glucagon have been established. Although it was possible to employ similar precepts to the development of both hormone assays, the establishment of a reliable glucagon radioimmunoassay was complicated by the poor immunogenicity and instability of …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… at minimizing the need for TPN are necessary. Glucagon-like peptide-2 (GLP-2) may be a therapeutic agent as it reduces TPN associated atrophy and increases enzyme and transporter activity. To examine this, we coinfused GLP-2 with TPN and found increased ileal mRNA and protein abundance of the …
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Regulation of IGF-1 bioactivity by dietary hormones, impact of glucagon and insulin-induced hypoglycemia
… der vorliegenden Studie war, die Wirkung von Glucagon und Insulin-induzierter Hypoglykämie auf die IGF-1 -Bioaktivität als mögliche Mechanismen zu characterizieren. In einer doppelblinden, Placebo-kontrollierten Studie wurde Glukagon intramuskulär 13 Patienten mit T1DM (6 Männer / 7 Frauen; [ …
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