Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"glomerulopathy"”.
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Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
In this study, adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional …
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Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN
… of the complement classic pathway, and C3 Glomerulopathy (C3G), with predominant complement alternative pathway (AP) activation. C3G is further classified in Dense Deposit Disease (DDD) and C3 glomerulonephritis (C3GN). <br></br><br></br> The first part of the thesis describes a large …
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Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
… chains. The mouse develops a type I collagen glomerulopathy that has previously been shown to initiate postnatally and progress in a gene dose-dependent manner, accumulating type I collagen within the renal mesangium, resulting in podocyte foot effacement and proteinuria. In this study we …
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The characterization of obesity and noninsulin dependent diabetes mellitus in Swiss Webster mice associated with late-onset hepatocellular carcinoma
… neogenesis, bacterial pyelonephritis, membranous glomerulopathy, and late-onset hepatic tumors with macrosteatosis, microsteatosis and hydropic change in aged males. Serum insulin correlated with blood glucose in a nonlinear pattern suggestive of islet exhaustion. Circulating leptin levels showed …
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Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome
… glomerulonephritis (IC-MPGN), the C3 glomerulopathy (C3G) and the podocytopathies, usually characterized by steroid-resistant nephrotic syndrome (SRNS). The first part of the thesis focused on IC-MPGN and C3G. We found likely pathogenic (LP) variants in complement alternative pathway …
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ApolipoproteinE-Sendai (Arg 145 ->Pro) : Expression, Reinigung und Charakterisierung einer Apolipoprotein E-Variante, die mit der Lipoprotein-Glomerulopathie assoziiert ist
Varianten des Apolipoprotein E(ApoE)sind in Zusammenhang mit der Lipoprotein-Glomerulopathie aufgetreten, einer neuen Nierenerkrankung, bei der es zur Ablagerung von Lipoproteinen in glomerulären Kapillaren kommt. Ein Drittel der betroffenen Patienten sind heterozygot für ApoE-Sendai(Arg145->Pro). …