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Showing 1 to 20 of 37 for “"globular proteins"”.
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Interfacial rheology of globular proteins
… as blood contains a mixture of serum albumin proteins with various other smaller surface-active components. Proteins and other surface active molecules are often adsorbed at an air-liquid or liquid-liquid interface due to favorable thermodynamics, and these interfaces play a role in such …
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The dynamic compressibility of globular proteins
Submitted by Carolyn Mead (cmead2@illinois.edu) on 2011-06-09T14:21:47Z No. of bitstreams: 1 1983_hardy.pdf: 2699162 bytes, checksum: cab60515b9f31d814d840384076c922e (MD5)
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A Computational-Experimental Study of Small Globular Proteins
The folding of small globular proteins is studied using a combination of experimental and computational techniques. The use of several experimental probes to study the formation of secondary and tertiary structure of proteins is stressed to obtain a description of their folding. Molecular dynamics …
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A Computational - Experimental Study of Small Globular Proteins
The folding of small globular proteins is studied using a combination of experimental and computational techniques. The use of several experimental probes to study the formation of secondary and tertiary structure of proteins is stressed to obtain a description of their folding. Molecular dynamics …
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Design of Single-Chain Polymer Nanoparticles to Mimic Globular Proteins
While globular proteins exhibit an impressive range of precise functionalities, their sensitivity to environmental changes has motivated scientists to pursue two complementary strategies: (1) engineering and designing proteins directly or indirectly, and (2) exploring synthetic alternatives with …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
The canonical Wnt pathway is a vitally important signalling pathway that plays an important role in cell proliferation, differentiation and fate decisions in embryonic development and in the maintenance of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the …
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Reciprocity of Effects and Multiple Ligand Interactions on Ligand Bindingto Globular Proteins
Made available in DSpace on 2014-12-10T23:24:36Z (GMT). No. of bitstreams: 1 7514130.pdf: 4061557 bytes, checksum: 31737df743b9f660576fd909b6fb3e07 (MD5) Previous issue date: 1975
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An Investigation of Phase Behavior and Crystal Nucleation Kinetics in Solutions of Globular Proteins
… problems can be found in the crystallization of globular biological macromolecules. Recent progress has been made in locating conditions favorable for crystal growth based on characterizing the strength of particle interactions. The strength of particle interactions can be controlled using …
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Rheological and microstructural characterization of pea, lentil and almond protein gels
… seeds generally contain 20% to 30% protein. Food proteins are natural food ingredients that can be used as fortifying and structuring agents in a variety of foods. The gelation of proteins (mainly globular proteins) has received considerable attention for some years because of its potential …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… recognition and catalytic capabilities of globular proteins makes these biomolecules promising candidates in a broad array of applications, including industrial production of commodity chemicals, point-of-care diagnostics, and therapeutics. Self-assembly of globular protein-polymer …
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Predicting self-assembly in globular protein-polymer bioconjugates
Globular proteins offer powerful solutions for addressing challenges in the fields of medicine, industry, defense, and energy. Enzymes perform reactions with high efficiency and specificity, allowing for minimal generation of undesired side products even while exhibiting rapid turnover-traits …
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Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury
… series of protein kinases, which are a group of globular proteins that reversibly phosphorylate downstream substrates to alter the transcriptional patterns of local and surrounding cells. While these altered kinase activities at the cellular level represent compelling targets for therapeutic …
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Advances in structure and small molecule docking predictions for crystallized G-Protein coupled receptors
… been long worked on in the context of native, globular proteins. In this work it is extended to transmembrane proteins, which requires an explicit integration of the lipid bilayer into the loop prediction calculation. In the initial work, this new approach to loop prediction yields highly …
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Hindered transport in composite hydrogels
… respectively. For the diffusion studies, two globular proteins (ovalbumin and bovine serum albumin) and three narrow fractions of Ficoll, a spherical polysaccharide, were used. For the partitioning and convection studies, four narrow fractions of Ficoll were used. Diffusivities of …
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Coherent two-dimensional infrared spectroscopy : a study of coupled vibrations
… in conformationally complex polypeptides and proteins with well-defined secondary structures. 2D IR spectroscopy of β-hairpins and globular proteins with antiparallel (AP) β-sheet domains is studied to identify 2D markers of AP β-sheet conformation. The experiments on β-hairpins and proteins …
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Dynamics of oxygen penetration and diffusion into horse skeletal myoglobin revealed by quenching of zinc protoporphyrin IX fluorescence
… of tryptophan fluorescence in a number of globular proteins provided some of the early experimental evidence for conformational fluctuations in proteins. Gratton et al. (Biophysical J. 1984. 45:789-794) proposed a sequential two step model called the dynamic model for oxygen quenching of …
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Protein structural dynamics and thermodynamics from advanced simulation techniques
… in three different families of peculiar proteins. These proteins are, for reasons such as the presence of an intermediate state in the folding path or topological constraints or large size, different from ideal systems, as may be considered small globular proteins that fold in a two state …
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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… of DNA wrapped around an octamer of core histone proteins composed of four histone species: one histone H3/H4 tetramer and two histone H2A/H2B dimers. Histones are basic globular proteins rich in lysine and arginine residues, with unstructured N-terminal "tail" regions protruding outside the …
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An interdisciplinary study of the mechanical and dynamic properties of α-solenoid repeat proteins
Tandem-repeat proteins differ from globular proteins, both in their biophysical characteristics and in how they interact with their respective partners, yet they comprise nearly one third of the human proteome and are central to many cellular processes and disease phenotypes. Repeat proteins have …
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Case studies in the modeling and control of continuous pharmaceutical manufacturing processes
… second work considers the production of small, globular proteins by the yeast Pichia pastoris. A model for copy number stability is developed and validated using data in open literature and data generated at MIT. The third work concerns the production of monoclonal antibodies (mAbs) using …
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