Global ETD Search
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Showing 1 to 12 of 12 for “"globins"”.
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Interactions Between Heme-Globins and Ligands
Neuroglobin (Ngb) is a hexacoordinated heme protein closely related to the pentacoordinated hemoglobin (Hb) and myoglobin (Mb) and in the central and peripheral nervous systems with expression in some endocrine tissues.1–5 Ngb is believed to play roles in: sustaining ATP production under anaerobic …
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Ligand Diffusion Pathways and Mechanisms for Regulating Oxygen Affinity in Two Model Invertebrate Globins: The E7 Gate and Apolar Tunnel
The major pathway for O 2 binding to mammalian myoglobins (Mbs) and hemoglobins (Hbs) involves transient outward movements of the distal histidine (HisE7), which allows ligand migration into the distal portion of the heme pocket. This E7 gate pathway appears dominant in vertebrate Hbs and Mbs. …
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Ligand discrimination and inhibition of heme iron autooxidation by myoglobin: Site-directed mutagenesis of a synthetic gene
Globins have evolved under strong selective pressure to overcome the natural tendency of a free heme prosthetic group to bind carbon monoxide (CO) 1000-fold more tightly than atmospheric dioxygen (O$\sb2$). Without protein-directed discrimination between these ligand molecules, the basal production …
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The amino acid sequence of the major alpha globin of the rat (Wistar, Rattus norvegicus)
… cysteine, which is unique among the mammalian ∝ globins. The occurrence of this externally situated cysteine was suggested to be responsible for the in vitro crystallizing property of rat haemoglobins. 5. Structural and functional constraints of the haemoglobin molecule were shown to be a major …
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Serial and Single Crystal Studies of Ligand Binding to Radiation Sensitive Haem Protein DHP-B
… function. What makes DHP different from other globins is not just its peroxidase function, but its flexible distal histidine that is located at the opening of the distal pocket, this is essential to its peroxidase function. The main aims of this study are to better understand how and also where …
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Characterization of the nifUHD cluster and a new myoglobin-like gene from Nostoc commune UTEX 584
… in general the spectra were more like those of globins than cytochromes. Based on these characteristics and the sequence similarity to the P. caudatum mnyoglobin, we proposed the name cyanoglobin, with the gene designation glbN and the protein designation GlbN. Western analysis of GlbN …
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Molecular assembly and function of Androglobin, a novel chimeric globin.
… haem iron species, which is highly unusual for globins and similar to that observed for NO binding to cytochrome c’. Adgb exhibits a higher NiR activity than other globin members although, similar to that of Globin X. Therefore, it can be proposed that Adgb may have a specialised function in …
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Gas migration inside proteins: Mechanism, characterization, and applications
… topic for many classes of proteins such as globins, oxygenases, and oxidases, which store oxygen gas or use it for enzymatic purposes. One reason why this process has not received prominent attention in recent years was because of difficulties in identifying the pathways taken by oxygen or …
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Studies of the effect of cysteine and heme pocket mutations of the nitric oxide dioxygenase and nitrite reductase activities of human Cytoglobin and Androglobin heme domain
… tissues along with the interplay between hemoglobins and hypoxic tissues have been an area of interest, the nitrite reductase activity (NiR) and the nitric oxide dioxygenase activity (NOD) working in tandem is a proposed regulatory response which enhances oxygen levels in hypoxic tissues, …
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Caratterizzazione strutturale e funzionale dei sistemi emoglobinici di due specie di pesci (Mugil cephalus e Ophisurus serpens) e di due varianti emoglobiniche umane (HbRoma e HbF-SS-Monserrato)
… and funcional characterisation of human hemoglobins natural variants and those present in different animal species. We report the identification and characterisation of two new hemoglobin variant, never described before, that we have named HbF-Monserrato-Sassari [Gγ93(F9) Cys Arg] and Hb Roma …
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β-Globin Enhancers Regulate Bistable Gene Expression States
Multiple enhancers can coordinately regulate a target gene to ensure robust expression. Under the failure rate model, each redundant enhancer contributes a probability of target gene expression in the cell, and genetic deletion will cause single-cell expression phenotypes. However, this model has …