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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 30 for “"global regulator"”.

  1. Characterizing cell-cycle as a global regulator of stochastic transcription and noisy gene expression in S. cerevisiae

    Quinn, Katie J. (Katie Julia)Massachusetts Institute of Technology2014

    … expression noise impacts the function of gene regulatory networks, depending on its origins. Hence, a prerequisite for understanding or designing gene regulatory networks is characterizing the origins and statistics of the noise. Variability has been largely attributed to the inherently …

    mit Repository record

  2. The in planta role of the global regulator Lrp in the bacterial phytopathogen Pantoea stewartii subsp. stewartii

    Reynoso, GuadalupeVirginia Tech2022

    … a bioinformatics approach, the transcriptional regulator Lrp of P. stewartii was present in the same node of the phylogeny as homologues from other closely related phytopathogens. This demonstrates that Lrp from P. stewartii and such homologues have evolved from a recent common ancestral gene. …

    vt Repository record

  3. The role of global regulator Fis in regulating the expression of lapF and the hydrophobicity of soil bacterium Pseudomonas putida

    Lahesaare, Andrio2018

    tartu

  4. Purification of Global Regulator, Spx, and RNA Polymerase from Staphylococcus aureus for Use in In Vitro Transcription of Redox Genes

    McBride, Jane

    Spx is a global regulator discovered in Bacillus subtilis to suppress basal growth and development processes and activate transcription of genes involved in thiol homeostasis when a cell encounters oxidative stress. Its activity relies on reversible thiol-disulfide bond formation and binding RNA …

    uno Repository record

  5. Investigating the role of Leucine-Responsive Regulatory Protein (Lrp) in the production and regulation of specific virulence factors in Pseudomonas aeruginosa

    Fick, Kendra2028

    … sensing virulence factors. Leucine-responsive regulatory protein (Lrp) is a known global regulator in <em>E. coli</em> and if proven to be a global regulator in <em>P. aeruginosa</em>, it could be a potential new target in <em>P. aeruginosa</em> infections. The virulence factors pyocyanin, …

    kennesaw Repository record

  6. Phenotypic Analysis of the Regulatory Role of the Leucine-Responsive Regulatory Protein (LrpPA) in Pseudomonas aeruginosa

    Larson, Stephanie D.2014

    … new targets for therapy. The leucine- responsive regulatory protein (Lrp) could be a promising target for treatment. The ortholog in <em>Escherichia coli</em> is a global regulator of metabolism and regulates many genes related to amino acid degradation, transport and synthesis. There are …

    kennesaw Repository record

  7. c-Myc regulates transcriptional pause release and is a global amplifier of transcription

    Lin, Charles YangMassachusetts Institute of Technology2012

    … predominant mechanism by which c-Myc regulates global transcription in both healthy and tumor cells is poorly understood. In this thesis, I present evidence that c-Myc is a global regulator of RNA Polymerase II (RNA Pol II) transcriptional pause release. Transcriptional pausing occurs when …

    mit Repository record

  8. Structures and Regulation of the N6-Methyladenosine Methyltransferase METTL16

    Doxtader, Katelyn AshleyUT Southwestern Medical Center2020

    … SAM homeostasis, implicating METTL16 as a global regulator of methylation in the cell. Here, I present structural and biochemical data towards determining the specificity, function and regulation of both the METTL16 and METTL3/METTL14 methyltransferases. METTL16 uses a consensus RNA …

    utswmed Repository record

  9. Integrated functional anlaysis of quorum-sensing in the rice pathogenic bacterium Burkholderia glumae

    Chen, RuoxiPlant Pathology and Crop Physiology2022

    … production. The present study identified regulators required for the tofI- and tofR-independent pathways, including flagella transcriptional activator, diguanylate cyclase, O-antigen polymerase family protein, QsmR QS-dependent master regulator and one hypothetical protein with its …

    lsu-thes Repository record

  10. Etude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs

    Ndagano, DoraULiège - Université de Liège2011

    … specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread.

    liege Repository record

  11. Chromatin Regulators of MYC Oncoprotein Activity in Cancer

    Tu, William Bo Chen2017

    … of virtually all cancer types. MYC is known as a global regulator of transcription that controls diverse physiological and oncogenic functions. Though there are 35 yearsâ worth of research on this protein, mechanistic understanding and therapeutic targeting of MYC are still needed. We hypothesize …

    toronto-retro Repository record

  12. Characterization of two component systems of Acinetobacter baumannii.

    Alsaadi, YasserUniversity of Ontario Institute of Technology2014

    … for this pathogen. This work investigated global mechanisms of antibiotic resistance and virulence of the problematic pathogen A. baumannii, in particular those mediated by two component regulatory systems (TCSs), that typically consist of a membrane bound sensor kinase and a cognate …

    uoit Repository record

  13. Phenotypic variation in Photorhabdus temperata K122

    McWeeney, Hilton DonalNational University of Ireland Maynooth2011

    … variation - the LysR-type transcriptional regulator HexA and the ‘adaptation to stationary phase’ AstR-AstS two component signal transduction system. A putative DNA binding protein, Ner, has also been shown to influence the phenotypic switch when overexpressed. This study has confirmed the …

    maynooth Repository record

  14. Light-sensing in bacteria

    Vermeulen, Albertus Jan[Bloomington, Ind.] : Indiana University2015

    … the PYP-phytochrome hybrid Ppr plays a role as a global regulator of transcription. A BLUF and a bacteriophytochrome on the other hand showed changes in expression levels of a number of genes involved in motility. Lastly, deletion of a LOV domain containing protein did not result in any …

    iu Repository record

  15. The Expression of the Transcription Factor Broad and RNA-Binding Factors in the Midgut of the Mosquito Aedes Aegypti During Metamorphosis

    Ray, KathrynThe Graduate School and University Center of The City University of New York2017

    … transcription factor <em>BROAD (BR)</em> is a global regulator of insect gene transcription and governs the timing of the commitment to pupate. I determined <em>BR</em> expression in the <em>Ae. aegypti</em> midgut by qPCR, and correlated its expression with that of nine miRNAs and three …

    cuny-grad Repository record

  16. Functional dissection of ParB homologue and global regulatory protein KorB of RK2

    Muntaha, Sidra TulUniversity of Birmingham2010

    … functions. KorB (358 aa) has dual roles as a global regulator and as an active partitioning protein. This study focuses on its role as a global regulatory protein and its interaction with DNA, RNAP and other repressor proteins (e.g KorA and TrbA) of RK2. It is shown for the first time that DNA …

    birmingham Repository record

  17. Structural and Functional Characterization of Cyanoglobin: A Peripheral Membrane Hemoglobin in Nostoc commune UTEX 584 (Cyanobacteria)

    Thorsteinsson, Marc VictorVirginia Tech1997

    … The 5' region of glbN interacted with NtcA, the global regulator of nitrogen metabolism in cyanobacteria, which may provide an indication of the nitrogen deprivation signal required for cyanoglobin expression in vivo. Finally, the isolation and N-terminal sequencing of a potential cyanoglobin …

    vt Repository record

  18. Studies on the Role of Histone-like Proteins in Gene Regulation in Uropathogenic Escherichia coli Isolate 536

    Müller, Claudia MariaUniversität Würzburg

    … nucleoid structuring protein H-NS is a global regulator in Escherichia coli that has been intensively studied in non-pathogenic strains. No comprehensive study on the role of H-NS and it’s homolog StpA on gene expression in a pathogenic E. coli strain has been carried out so far. …

    wurz-thes Repository record

  19. CONTRIBUTIONS OF SIGMA-B AND PRFA TO STRESS RESPONSE AND VIRULENCE GENE EXPRESSION IN LISTERIA MONOCYTOGENES

    Kazmierczak, Mark J.American Society for Microbiology Press2005

    … genes. The alternative sigma factor sigmaB is a global regulator of genes active under environmental stress conditions and during stationary phase growth. I identified a large portion of the genes regulated by sigmaB using a promoter consensus sequence search and microarrays. sigmaB directly …

    cornell Repository record

  20. Targeting Receptor-Histidine Kinase Signaling in Staphylococcus Aureus

    Lyon, Gholson J

    … results have facilitated the development of global inhibitors of virulence in S. aureus, which, in one case, consists of a truncated version of one of the naturally occurring AIPs. Cell-based in vitro assays of this peptide have demonstrated IC50's in the nanomolar range for inhibition of the …

    rockefeller Repository record

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