Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"gliosis"”.
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E2F6 in axial skeletal development and gliosis
… suppressed gliotic response after neural injury. Gliosis occurs in response to neurodegeneration, ischemia, and neuronal cell death. This process provides neuronal protection by restricting inflammation and regulating the concentration of molecules in the extracellular environment.
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
The process of astrogliosis, or reactive gliosis, is a typical response of astrocytes to a wide range of physical and chemical injuries. The up-regulation of the astrocyte specific glial fibrillary acidic protein (GFAP) is a hallmark of reactive gliosis and is widely used as a marker to identify …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… resulting in an attenuation of reactive gliosis and the production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of these studies was to determine the involvement of OPN and an RGD containing peptide in the regulation of glia and …
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Improving dopamine monitoring with NCAM and the effects of intranasal oxytocin on dopamine signaling in the rat brain
… likely results in an inflammatory response (i.e. gliosis) that can restrict FSCV recording of DA signals. Neural cell adhesion molecule (NCAM) may reduce gliosis and potentially improve the ability of FSCV electrodes to monitor DA signaling. Chapter 1 Methods: FSCV electrodes were coated with NCAM …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
… that rmTBIs didn’t enhance the extent of gliosis in AD mice. We conclude that an increased risk of neurodegeneration is not a predetermined outcome from rmTBIs early in life. A future investigation of the expression of specific receptors (e.g., TREM2) and neuronal loss can better …
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The effects of perinatal choline supplementation on neuroinflammation in the plaque niche of APP-NL-G-F mice
… choline supplementation on astrocytosis and gliosis associated with amyloid beta. The size of ionized calcium-binding adaptor molecule 1 (Iba1)-positive cells and clusters were larger in control diet APPNL-G-F mice, although the number and total area covered by Iba1+ cells/clusters were …
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ENCEFALOMIELITE VIRAL EQUINA EM DOIS POTROS NO AGRESTE DA PARAIBA
… of the spinal cord, associated with diffuse gliosis, necrosis of neurons with foci of neuronophagia. The meninges were infiltrated by lymphocytes, neutrophils and macrophages, characterizing marked non-suppurativemeningomyelitis associated with neuronal necrosis and neurophagia. The …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… in the SN. This was accompanied by striatal gliosis and both gliosis and inflammation in the SN.<br/>Mice deficient for Nedd4-1 in their dopaminergic neurons were found to have an increased α-synuclein burden in these cells but did not exhibit the dopaminergic cell loss in the SN as …
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Correlato clínico de los hallazgos histopatológicos en la enfermedad de Creutzfeld Jakob
… donde se medió espongiosis, pérdida neuronal y gliosis, para obtener un “índice de daño”. El análisis clínico se basó en cinco en la evolución de los cambios conductuales y cognitivos, estado de vigilancia y sueño, compromiso visual, alteraciones motoras y fenómenos epilépticos. Finalmente la …
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A Glial Role in the Action of Electroconvulsive Therapy
… demonstrate that ECS, without inducing reactive gliosis (a hallmark of brain damage), increase glial cell activity. Given that glial cells (by supporting, communicating with and nourishing the surrounding neurons) play a vital role in neuronal network, we hypotehesize that these glial cell …
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Intra-Regional Differences in Cerebellar Vulnerability of Spinocerebellar Ataxia Type 1 Mice
… with exacerbated Purkinje cell atrophy and gliosis in the posterior vermis. Importantly, I identified region-enriched genes and pathways of pathogenesis that may contribute to resistance and vulnerability to SCA1 pathogenesis across the cerebellar cortex. I found that calcium activity of …
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Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… mammalian retina respond to injury with reactive gliosis, which if persistent, can lead to loss of Müller cell function and devastating vision loss. Despite this, multiple lines of evidence suggest that mammalian Müller glial cells possess a latent ability to regenerate retinal neurons. This work …
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Genetic Networks Modulating Retinal Injury
… of acute phase genes Fos and Stat3, reactive gliosis genes Gfap and Cd81, and apoptotic gene Casp3. In this body of work I have moved beyond cataloging changes in the transcriptome to identifying candidate genes modulating the retinal response to injury. During this process I developed an …
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Pathobiology of neuroinflammation and basal ganglia circuitry in Parkinson’s Disease
… to recapitulate the reactivity associated with gliosis in PD brain. The activation of these glial cells and pathology of neurons in the basal ganglia causes the hallmark symptoms of PD. The symptoms of PD are termed parkinsonism. These are thought to result, at least in part, from alterations in …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… Immunohistochemistry revealed axonal damage, gliosis, and axon-myelin alterations in the connected grey and white matter regions, as well as secondary neurodegeneration in the thalamus. Our findings indicate that cortical stroke triggers chronic, region-specific alterations in anatomically …
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Antioxidant Biomarkers and Nutraceutical Therapeutics in Neurodegeneration and Neurotrauma
… show that Immunocal® significantly reduces astrogliosis at 2 weeks and 2 months in mice post-rmTBI and microgliosis at 72 hours following more severe repetitive mild-moderate TBI.</p> <p>Persistent pathology from rmTBI has been linked to an increased risk for developing neurodegenerative disease …
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
… diagnosis of BINT, and it is speculated that gliosis associated markers (myo-inositol) may be a potential biomarker for blast-induced memory impairment.
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OPTIMIZATION OF AAV9 GENE THERAPY FOR SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS TYPE 1 USING IN VIVO DISEASE MODELS
… cords, increased motoneurons number with reduced gliosis and astrogliosis. We also found a restoration of the IGF1 axis, altered in nmd mice. To support the translatability of the therapy, we confirmed the lack of a significant alteration of the major toxicity biomarkers after the treatment and …
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Cognitive, Psychiatric, And Neuropathological Manifestations Of Repetitive Mild Traumatic Brain Injury
… outcomes of rmTBI included reactive gliosis, axonal degeneration, elevated levels of Aβ (1-42), β-amyloid, p-tau, TDP-43, and significant thinning of several white matter tracts. Notably, these outcomes occurred in mice receiving head impacts that did not delay recovery of the …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… which histologically present as non-specific gliosis, synaptodendritc damage and loss of white matter and myelin. Furthermore, the severity of white matter damage correlates with the length of ART duration. However, almost no studies have been performed to determine how the myelin sheath or …
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