Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 144 for “"gliomas"”.
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Factores pronósticos en gliomas de alto grado
Los gliomas de alto grado son la tumoración cerebral maligna primaria más frecuente en adultos. Debido al envejecimiento de la población, el diagnóstico en las personas de edad avanzada es cada vez más frecuente y, a pesar de los tratamientos estandarizados, existen diferencias en supervivencia …
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Gene and Protein Expression in Human Gliomas
The human gliomas are the most common primary brain tumours. They are highly aggressive with a rapid fatal progression for the patient. The invasive growth pattern and inherent resistance to radiation and chemotherapy account for a lack of efficient therapies. Several novel therapeutic regimes are …
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Characterisation of cytokine secretion in malignant gliomas
Cytokines are proteins produced by cells of the immune system. The working hypothesis of the thesis is to show that the lymphocytes and glial cells in Glioblastoma Multiformae patients have an altered pattern of secretion of cytokines compared with low-grade and non-cancerous patients. Lymphocyte …
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Molecular Consequences of High Taz Expression In Gliomas
<p>Diffuse high grade gliomas are complex and lethal neoplasms of the adult central nervous system that are driven by a range of genetic and epigenetic alterations. Molecular classification of these tumors has identified different transcriptional subtypes, the most notable being Proneural (PN) and …
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Long-Term Neuropsychological Effects in Survivors of Pediatric Low-Grade Gliomas
… of the problem: Survival rates of low-grade gliomas (diagnosed and treated during childhood) have improved resulting in a population of long-term survivors, albeit with limited knowledge of their neurocognitive function, quality of life, and adaptive function. Methods: Patients treated at The …
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). To begin to examine the role of MMP-1 in these tumore, two human glioma cell lines were …
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Design of a Patient Education Booklet Approaching Gliomas at the Cellular Level
The file named "hilbornnicole.pdf" is the primary dissertation file. To access the supplemental tutorial, click on the file named "GliomaBooklet.pdf".
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Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
… TEAD, and the mesenchymal marker FN1 in human gliomas. Western analyses demonstrated increased expression of TAZ, TEAD4, and FN1 in GBM relative to lower grade gliomas. We also identified CpG islands in the TAZ promoter that are methylated in most lower grade gliomas, but not in GBMs. …
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… of RNF8 in SAC regulation, with relevance to gliomas.
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
Glioblastoma (GBM) is the most common and lethal primary brain cancer in adults despite aggressive treatments with surgery and chemo-radiation. Advances in electrotherapeutics offer a foundation for developing new treatment modalities that exploit an innate vulnerability of glioblastoma (GBM). Low …
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RAPID DETECTION OF THE IDH1 R132H MUTATION IN GLIOMAS USING RECOMBINASE POLYMERASE AMPLIFICATION
<p>Glioblastoma is the most common form of brain cancer and patients diagnosed have an average life expectancy of about a year. Northern Michigan University developed an assay to improve diagnosis of the IDH1-R132H mutation. Diagnosis guided resections has potential to extend life expectancy up to …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… model was created through culturing spontaneous gliomas from these mice as neurospheres. These lines displayed stem cell markers and produce highly invasive gliomas when grafted into the brains of immunocompetent C57Bl/6 mice. We hypothesized that Type-I interferon (IFNα/β), could be playing a …
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Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
… a neural stem/progenitor cell (NSC) origin for gliomas, however strict exprimental evidence was still lacking. To examine the role of NSCs in glioma, we developed an NSC-specific tamoxifen-inducible nestin-cre driver mouse. When crossed to the NF/p53/Pten flox mice and induced with tamoxifen at …
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Low grade gliomas treated at the University of Cape Town Academic Hospital complex: 2001-2017
… nervous system tumours in children are low grade gliomas (LGG). Long-term survival rates are high with a slow, progressive course. Tumour location and extent of resection affect outcome. Adjuvant therapy has an important role. Rationale: This study evaluated the demographic data of our patient …
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Advancements in the Treatment of Malignant Gliomas and Other Intracranial Disorders With Electroporation-Based Therapies
… of H-FIRE for the treatment of malignant gliomas and other intracranial disorders. To advance the versatility, usability, and understanding of H-FIRE for intracranial applications, my PhD thesis focuses on: (1) characterizing H-FIRE-mediated BBB disruption effects in an in vivo healthy …
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