Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"glioblastoma stem cell"”.
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Alteration of differentiation in glioblastoma: from spatial transcriptomics approaches to the identification of a suppressor event
Glioblastoma is one of the most devastating forms of primary brain tumor, with a survival of 14.6 months from the diagnosis. Despite the aggressive treatments used in the clinic, consisting of surgical resection followed by radiotherapy and concurrent chemotherapy using temozolomide, the absence of …
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In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery
Glioblastoma is a deadly brain cancer with discouraging standard of care. New methods like convection enhanced delivery and chimeric antigen receptor T cells (CAR-T) are promising treatments that can be translated to glioblastoma. In this study, CAR-T cell flow through a hydrogel was explored in …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… and functions of ecDNA-derived enhancer RNA in glioblastoma (GBM). GBM is a devastating cancer type that requires mechanistic knowledge of its development and progression. Understanding ecDNA and eRNA related mechanisms in GBM gene regulation will provide new knowledge and potentially new …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
<p>Glioblastoma is the most common primary malignant brain tumor in adults, with limited treatment options resulting in a poor prognosis. Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma and contributes to tumor growth and treatment resistance. Inhibitors of LSD1 have shown …
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METFORMIN, CLIC1 AND TRANSCRANIAL STIMULATION: THE BASIS OF A NEW TARGETED THERAPY AGAINST GLIOBLASTOMA RELAPSE
Glioblastoma (GBM) is the most prevalent type of brain tumor and has a very poor prognosis. The current standard of care includes surgery to remove the mass of the tumor, followed by chemoradiation therapy. However, this technique is neither effective nor specific, and tumor recurrence occurs …