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Showing 1 to 20 of 143 for “"glioblastoma multiforme"”.
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
Glioblastoma (GBM) is the most aggressive brain tumor that originates from glioblastoma stem cells (GSCs). In the brain, GSCs are supported by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
<p>Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent …
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New advances in the chemotherapy of Glioblastoma multiforme
Glioblastoma multiforme is a primary tumor of the Central nervous System affecting mainly the brain. It is classified by the world health organisation as a grade IV glioma. It is indeed a very deadly tumor with an average life expectancy after diagnosis of about 14 months even after surgery, …
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Microcapsule drug delivery device for treatment of glioblastoma multiforme
… including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. The use of drugs capable of crossing the blood-brain barrier has shown modest prolongation in patient survival, but not without unsatisfactory systemic, …
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A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
… pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating glioblastoma …
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Development of a novel combination radio- chemotherapy for glioblastoma multiforme
Glioblastoma multiforme is an invariably terminal cancer, with 5-year survival rates as low as 1.9% in some patient groups. The current treatment for glioblastoma is surgery, external beam radiotherapy and adjuvant and concomitant temozolomide chemotherapy. Treatment will fail due to an inherent …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
Glioblastoma Multiforme (GBM) is an aggressive brain tumour with poor prognosis, accounting for up to 50% of all gliomas. For decades, treatment of this tumour has been limited to surgery with concurrent radiation and chemotherapy with temozolomide (TMZ). However, recurrence is inevitable and …
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Il sistema dell'Eme Ossigenasi-1 (HO-1) nel Glioblastoma Multiforme
… sistema nervoso centrale (SNC) nell'adulto. Il glioblastoma rappresenta la metà dei gliomi diagnosticati ed è il tumore cerebrale più aggressivo con una sopravvivenza media dei pazienti di 14-17 mesi. L'Eme Ossigenasi (HO) è l'enzima che limita la velocità nel catabolismo dell'eme: questa …
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Novel Drug Discovery for Glioblastoma Multiforme Using Brain Tumour Initiating Cells
Glioblastoma (GBM) is the most common and aggressive adult primary brain tumour. Populations of cells with tumour initiating capacity, termed brain tumour initiating cells (BTICs), are thought to underlie the formation, growth and recurrence of GBM. As such, therapies that target this compartment …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
OBJECTIVE: Glioblastoma Multiforme (GBM), one of the most malignant forms of primary brain tumors, is characterized by its highly heterogenous genetic composition, aggressive infiltration of surrounding tissue, and resistance to current treatments. Gene expression analysis has characterized GBM …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
Glioblastoma Multiforme (GBM) is the most common lethal brain tumour associated with dismal survival rate. GBM is considered to be an incurable malignancy as these tumours evade all intricate attempts of therapy and no contemporary chemotherapeutic regimen is effective. Although the existence of …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
<p>Glioblastoma multiforme (GBM) is the most common malignant form of human brain cancer. GBM tumor cells overexpress the protein Basigin (Bsg) at the cell surface where it contributes to malignancy via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, …
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
<p>GBM tumors are the most aggressive and, unfortunately, the most fatal form of brain cancer. GBM tumors with isocitrate dehydrogenase-1 (IDH1) mutation being expressed, lead to higher survival rates in patients that also have full resection of the tumor and chemotherapy. Without this mutation, it …
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Multifunctional Liposomal Carriers Encapsulating Temozolomide, RG7388 and Elacridar for Targeted Glioblastoma Multiforme Therapy
Glioblastoma multiforme is a grade IV brain tumour that is highly malignant and has a very low patient survival rate. A hurdle in glioblastoma therapy is bypassing the blood brain barrier. Thus, this study was aimed at designing and comparing two multifunctional liposomal therapies for the delivery …
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Contribution of Ectodomain Mutations In Epidermal Growth Factor Receptor to Signaling In Glioblastoma Multiforme
… EPIDERMAL GROWTH FACTOR RECEPTOR TO SIGNALING IN GLIOBLASTOMA MULTIFORME</strong></p> <p><strong>Publication No._________</strong></p> <p><strong>Marta Rojas, M.S. </strong></p> <p><strong>Supervisory Professor: Oliver Bögler, Ph.D.</strong></p> <p><strong></strong>The Cancer Genome Atlas (TCGA) …
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