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Showing 1 to 19 of 19 for “"glibenclamide"”.
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The effect of glibenclamide on the pathogenesis of melioidosis
… of patients (208 patients) who were treated with glibenclamide prior to admission. Patients with hyperglycaemia (but no diagnosis of diabetes prior to admission) had the same mortality rate as patients without diabetes. In vitro experiments found no inhibitory effect of glibenclamide on bacterial …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… metformin) and sulphonylureas (for example glibenclamide, also known as glyburide). In the placenta a network of apical ATP-binding cassette (ABC) transporters facilitates the efflux of substances away from the fetus, thereby protecting the fetus from exposure to unwanted substances …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
… of the mKATP channel with the sulfonylurea, glibenclamide. A demand ischaemia study uses dobutamine stress echo to compare LV function. The other uses transient coronary balloon occlusion to generate supply ischaemia during GLP-1 infusion, assessed by conductance catheter. A further transient …
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Studies on the stimulant action of human gamma-globulin on spontaneous contractility: interaction with K⁺-channel openers and postaglandin inhibitors
… noradrenaline on the rat mesenteric portal vein. Glibenclamide, a potassium channel antagonist, potentiated the action of human gamma-globulin on the portal vein by 45% and on its own had a biphasic (increase followed by a decrease) effect on the spontaneous activity of the portal vein . …
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Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… a cystathionine-β-synthase (CBS) inhibitor and glibenclamide, a KATP channel blocker. Although AOA (3mM) and glibenclamide (300 μM) had no effect (p>0.05) on [3H]NE release, they both reversed the inhibitory action of GYY 4137 (10-30 μM), ACS67 (0.1-1 μM) and L-cysteine (10 μM) on the …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… Co-application of the K⁺ATP channel blocker glibenclamide selectively increased the dopamine-releasing effect by complex I inhibitors in vitro, and potentiated the neurotoxicity of MPTP (a complex I inhibitor) on DAT and TH expression, in vivo. Mechanistic studies demonstrated that …
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Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus
… 0.2 mIU/L. The positive controls of acarbose and glibenclamide at a concentration of 1 mg/ml stimulated insulin secretion to 11.5 and 19.8 mIU/L respectively. In comparison, the positive controls acarbose and glibenclamide control produce a 5-8 fold greater increase in insulin secretion although …
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Role of KATP channels in angiogenesis
… polypeptides CNP or VEGF. Two KATP inhibitors, Glibenclamide and 5-Hydroxydecanoate (5-HD), abrogated both basal and CNP-induced CAM angiogenesis. In vitro, direct activators of KATP such as Nicorandil and SG- 209 and receptor-acting agonists such as VEGF and CNP, increased proliferation and …
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Exploration of Hypotensive Effects of Novel Hydrogen Sulfide Donors: Mechanisms and Their Delivery
… an inhibitor of endogenous H2S synthesis, and glibenclamide (GLBN), a KATP channel blocker. These studies confirmed that both endogenous H2S production and the activation of KATP channels are crucial in mediating the observed effects, thereby supporting the biological significance of the …
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Investigation of insulin releasing and glucose lowering effects of extract of selected plants used in African traditional medicinal practice
… with glucose alone or in combination with glibenclamide or plant extracts (50 mg/kg bw and 100 mg/kg bw). Results obtained in this study confirmed the presence of phytochemicals in all plant extracts. However, phytochemicals were more concentrated in aqueous extract than methanolic extract. …
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Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… channel opener, abolished spontaneous tone in a glibenclamide-sensitive fashion. In aortic cells from DOCA-salt hypertensive rats, ATP-dependent K+(KATP) channel currents were either absent or weak in response to challenges by elevated extracellular K+ and by cromokalim. These findings suggest …
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An Intramural, Tension-modulating Reflex in the Rat Caudal Artery
… hyperpolarization with BaCl<sub>2</sub> or glibenclamide also reduced EFS-induced relaxation. L-arginine reversed the effect of L-NAME. When either MB and KCl, L-NAME and KCl, or L-NAME and BaCl<sub>2</sub> were used, the EFS-induced relaxation was completely inhibited. The EFS-induced …
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Preparation and stability of organic nanocrystals. Experimental and molecular simulation studies.
… relatively insoluble drugs, the hypoglycaemic glibenclamide, the anti-inflammatory ibuprofen, and the anti-malarial artemisinin. The choice of crystal growth inhibitors/stabilizers was found to be critical and specific for each drug. The effect of the process variables, temperature, stirring …
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Ion-pair based Molecular Imprinted Polymers for bioanalysis and sustainable use of organocatalysts
… motif in the binding of a sulfonylurea drug, glibenclamide, both in solution and post-polymerisation, is presented. It is shown that under certain conditions, the acidic sulfonylurea drug is deprotonated by the basic anion of the ion-pair monomer, resulting in a charge transfer complex, …
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Ion channel modulation during Chlamydia trachomatis development
… K+ ionophore nigericin or sulfonylurea inhibitor glibenclamide promotes bacterial persistence. While these observations revealed an essential role for K+ during infection, the focus was the early replicative phase of the cycle. Since mid- cycle and late-cycle inclusions contain a heterogenous …
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Solvent Free Technologies for Polymer based Crystal Engineering and Drug Delivery
… purpose were carbamazepine, ibuprofen, glibenclamide which are BCS class II drugs and paracetamol from BCS class III drug was selected as model drug for solid dispersion manufacturing with PVP. VA64, HPMCP HP55, HPMCAS, Ethyl cellulose as polymers. In case of cocrystals selected drugs …
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Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices
… the ATP-sensitive potassium channel blocker, glibenclamide, indicated that this effect may be due to increasing the opening of these channels. Adenosine preconditioning was attempted using 10mM glutamate as an insult. It was shown that adenosine could not precondition against this effect in …
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Inhibition of excitatory neurotransmitter activity by hydrogen sulfide in bovine retina, in vitro
… Similar to AOA, the KATP channel blocker, glibenclamide had no effect on K+-induced [3H]D-aspartate release. However, it abolished the inhibitory effects of GYY 4137 (1 µM and 10 µM) and L-cysteine (1 µM and 10 µM) but not NAC (1 mM) on K+-induced [3H]D-aspartate release. These data suggest …