Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"glial scarring"”.
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
… BOP exposure) active neurodegeneration and glial scarring. Data suggested GABA shunting pathway was activated and phospholipase A2 regulated arachadonic acid pathway may be involved in cellular death cascades. In addition, increased myo-inositol levels in medial pre-frontal cortex (PFC) …
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Swelling properties of hydrogel coatings on neural devices
Glial scarring is a major problem seen in brain electrode implants that can hinder electrode function. One major contributing factor is the mechanical mismatch between the stiff electrode and the soft brain tissue'. Hydrogel coatings are being investigated to determine their effectiveness in …
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Modulating Neuroinflammation with Porous Templated Scaffolds
… Via the foreign body reaction, macrophages and glial cells develop a “glial scar” around implants, increasing electrode impedance and leading to time-dependent declines in electrode performance. During the first two years of my PhD, I worked with Dr. Bill Shain to study the brain’s foreign body …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… in the left hemisphere, and was surrounded by glial scarring. Implantation of a collagen scaffold one week after injury resulted in a modest cellular infiltrate four weeks later consisting of macrophages, astrocytes, and endothelial cells. The scaffold was able to fill the cavity and provide a …
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Application of self-rolled-up membrane technology for enhanced neuron guidance and alignment
… and complications from inflammatory response and glial scarring. Engineered therapies for neural regeneration are a burgeoning area of interest, with many techniques being explored to improve existing scaffolds for neural repair (e.g. nerve guide conduits), and develop new methods to manipulate …
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Tools for Monitoring and Modulating Cellular Communication
… of technologies which promote minimal glial scarring while maintaining chronic function. To this end, we have developed modular neural implants for focal dosing, allowing for fine discrimination and investigation of proximal anatomical locations, such as the dorsal and ventral shell of …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… BMP4 has also been implicated in modulating glial scarring and remyelination in sub-acute and chronic SCI in rodents. However, the role of BMP4 in early injury cascades after SCI is not well understood. This work sought to elucidate the impact of BMP4 upregulation in acute SCI by utilizing …
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Studying the glial cell response to biomaterials and surface topography for improving the neural electrode interface
… after implantation due to the development of glial scar tissue (Polikov et al., 2006; Zhong and Bellamkonda, 2008). The long-term effect of chronically implanted electrodes is the formation of a glial scar made up of reactive astrocytes and the matrix proteins they generate (Polikov et al., …
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… over time as lesions become chronic and prone to glial scarring and accumulation of inflammatory cellular debris. My finding that unlike in myelin regeneration, progesterone-induced effects on developmental myelin formation do not rely on signaling through the nuclear progesterone receptor, …