Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"glial fibrillary acidic protein (GFAP)"”.
-
Systematische Charakterisierung und Untersuchung der Inzidenz von Myelitis-assoziierten Autoantikörpern bei akuten Myelitiden
… der Prävalenz von Myelin-Oligodendrozyten-Glykoprotein (MOG), Aquaporin-4 (AQP-4) und glial fibrillary acidic protein (GFAP) Antikörpern bei PatientInnen mit Myelitis im Vergleich zu einer Kontrollkohorte. Es erfolgte eine retrospektive Rekrutierung von PatientInnen mit Myelitis und einer …
-
Isolation, Culture and Cryopreservaion of Neural Stem Cell
… a member of the class Ⅵ intermediated filament proteins and a well-known stem cell marker in the neural lineage. The nestin gene consists of four exons and three introns. It has been known that the nestin transgene containing the second intron is sufficient to direct tissue specific expression …
-
Endosomal Trafficking and Exosomal Secretion of Egfrviii
… reactive astrogliosis including an increase in glial fibrillary acidic protein (GFAP) and altered astrocyte morphology.</p> <p>These results reveal novel aspects of the endocytic trafficking of EGFRvIII that underlie its reduced degradation and the mechanism by which it is packaged into exosomes …
-
Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… regulation and barrier integrity. Increased glial fibrillary acidic protein (GFAP) fluorescence, a marker of activated astrocytes, appeared in hydrocephalic (Tmem67-/-) animals by immunohistochemistry as early as postnatal day (P)10. The tight junction proteins expressed in choroid plexus …
-
The Role of Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis
… a deficiency in the lysosomal enzyme, palmitoyl protein thioesterase 1: PPT1). A mouse model of INCL, the PPT1-deficient: PPT1-/-) mouse, was recently created by a targeted disruption in the CLN1 gene. The phenotype of the PPT1-/- mouse is similar to that found in human INCL patients, suggesting …
-
Diurnal and stimulated astrocyte morphology dynamics in the rodent central nervous system
… gyrus (DG) and suprachiasmatic nucleus (SCN). Glial fibrillary acidic protein (GFAP) branch terminal-points are significantly less numerous in the DG than the SCN. Terminal-points increase and decrease in complexity throughout the day-night cycle. Branching peaks at early night in the DG, but …
-
Investigating the regeneration behaviors of neuroglial cells on artificially made electrospun PCL scaffolds embedded with conductive nanomaterials
… system back to good health. Astrocytes (nerve glial cells) play a pivotal role in the health of the nervous system and are fundamental for controlling several activities, from synaptic transmission to homeostasis. Astrocytes are involved in all types of brain pathologies from acute lesions to …
-
Die Rolle des medialen Septums für die synaptogene Östrogenwirkung am Hippocampus
… wurden durch immunhistochemische Färbung auf glial fibrillary acidic protein (GFAP) untersucht. Die semiquantitative Auswertung der Astrogliafortsätze östrogenimplantierter Ratten ergab eine Abnahme der Faserdichte in CA1 und in CA3, jedoch nicht im Gyrus dentatus. Eine Veränderung der …
-
Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… The up-regulation of the astrocyte specific glial fibrillary acidic protein (GFAP) is a hallmark of reactive gliosis and is widely used as a marker to identify the response. In order to develop a reliable, sensitive and high throughput astrocyte toxicity assay that is more relevant to the …
-
The role of blood-borne factors in triggering atypical astrocytes
… that astrocytes lose expression of homeostatic proteins after mTBI, characterizing the changes in astrocytic protein expression as an "atypical astrocyte response." Yet, the upstream mechanisms that induce this atypical astrocyte response after mTBI have yet to be elucidated. In models of more …
-
Neurales tissue engineering zur Unterstützung anatomischer und funktioneller Wiederherstellung nach akuter experimenteller Rückenmarksläsion der adulten Ratte
… and dendritic responses using antibodies to glial fibrillary acidic protein (GFAP), growth associated protein-43 (Gap-43/B50), 200kDa phosphorylated neurofilament (NF200) and microtubule associated protein 2 (MAP-2). The type I collagen matrix was found to be biocompatible and acted as a …
-
A Comparative Analysis of the Neurochemical Properties of Olfactory Ensheathing Cells and their Biocompatibility in Various Biomatrices
Olfactory ensheathing cells (OECs) are the chief glial population of the mammalian olfactory nervous system and are thought to be responsible for the successful directional growth of new olfactory axons throughout the life of adult mammals. Due to this unique property, OECs have been targeted as a …
-
Novel Astrocyte-Specific Transgenic Mice Identify Distinct Populations of Transient Amplifying Progenitor Cells And Long-Lived Neural Stem Cells In the Subgranular Zone of the Adult Mouse Brain
… The most common and accepted astrocyte marker is glial fibrillary acidic protein (GFAP), but in normal, healthy adult brains, GFAP expression is limited to the neurogenic regions, white matter tracks, and pia. This limited expression is not a true representation of astrocyte distribution patterns …
-
ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… mock animals. These animals also had increased glial fibrillary acidic protein (GFAP) expression, indicating increased astrocyte activation, in the dentate gyrus and thalamus. In the Stat1-/- model of LASV infection, I found that 100% of survivors developed hearing loss post-infection, which …
-
Neuronal Differentiation and Functional Recovery after Transplantation of Human Mesenchymal Stem Cell in The Ischemic Rat Model
… cells were reactive for the astrocytic marker - glial fibrillary acidic protein(GFAP) and neuronal marker - neuronal nuclear antigen(NeuN). These findings show that some cytokine-inducted human mesenchymal stem cells were differentiated into neurons and astrocytes to replace the damaged neural …
-
Exploring the potential for biomarkers to aid forensic diagnosis of traumatic brain injury (TBI) – a systematic literature review and meta-analysis
… Biomarkers could offer potential insight. Proteins involved in neuroinflammation, such as systemic inflammatory biomarkers interleukin (IL)-1β, IL-6, and IL-10 and astroglia-associated biomarkers S100 Calcium-Binding Protein B (S100β) and Glial Fibrillary Acidic Protein (GFAP), have been …
-
An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… (NCAM), neural-cadherin (N-cadherin) and glial fibrillary acidic protein (GFAP). However, M. leprae-infected Schwann cells were able to align and associate with neurons in culture, proliferate along these neurons and subsequently produce myelin in a manner comparable to control cultures. …
-
Glutamate Imaging of Mouse Models of Neurodegeneration
… include markers of phosphorylated tau protein, synapse density, neuron density, glial cell reactivity, a glutamate transporter, and an NMDA receptor. GluCEST contrast correlated with 1HMRS-derived glutamate levels in the striatum of APP-PS1 mice (R2=0.91) and the thalamus of PS19 mice …
-
Stab Wounds to Rat Brains : Demyelination, Remyelination and the Cellular Response, Particularly of Oligodendrocytes
… were used. These were labels for glial fibrillary acidic protein (GFAP) and myelin/oligodendrocyte specific protein (MOSP) respectively. Light and electron microscopy were correlated using conventionally prepared and immunostained tissue. Immunocytochemistry for MOSP with light …
-
Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… production of this chemokine. <br>These glial fibrillary acidic protein (GFAP)-CXCL10 transgenic mice developed spontaneous, transgene dose- and age-related leukocyte infiltrates in perivascular, meningeal and ventricular areas of the brain that were composed of, surprisingly, …
Page 1 of 3