Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"glial cell activation"”.
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… irreversible apoptotic death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor for glaucoma, and lowering IOP is currently the only evidence based method for the clinical management of the …
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Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
… severity of human malaria infection, very little cellular infiltrate is identified on autopsy in fatal cerebral malaria cases, suggesting a novel mechanism of local inflammation drives this syndrome. Vascular congestion is a prominent feature of all malaria parasites, although some species promote …
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Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy
… of ECT. In the current thesis, we have studied cellular changes in an animal model of ECT - electroconvulsive seizures (ECS) - in limbic brain regions implicated in the pathophysiology of depression. In the first paper, we show that ECS enhances neuronal activation and endothelial cell …
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Nrf2 in metabolic related inflammation in the brain
… <i>Nrf2<sup>-/-</sup></i> mice display increased glial cell activation and activation of mitogen activated protein kinases and mitochondrial impairment. These may be indicative of OS-induced cellular dysfunction and is supported by an aggravated response to LPS, which potentiates IL-1β production. …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
<p>Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflammation and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… plays roles in fibrinolysis, wound healing, cell signaling, and inflammatory regulation. Increasing evidence links plasminogen to the regulation of inflammatory responses in many organ systems of the body and implicates plasminogen in the progression of a diverse range of pathologies. I aimed …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflamation and pain transmission. The proinflammatory molecule nitric oxide (NO) and protons are implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate gap …
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The computational modelling of the spinal cord neurons involved in the pain process
… subsequent research. This theory postulates that cells in the substantia gelatinosa, located within the spinal cord, act like a gate mechanism that modulates the flow of information through the spinal cord to the brain and thus impacts on the pain experience. The abundance of literature and …
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
… from patients with mood disorders have shown glial cell pathology. Electroconvulsive therapy (ECT) and pharmacological treatment with lithium have been used in the treatment of mood disorders for over 70 respectively 60 years, but the mechanisms behind their therapeutic effects remain elusive. …
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Role of Cerebral Vasculature and Effect of Circulating Exosomes in Propagation of Systemic Inflammatory Responses into the Central Nervous System
… nervous system (CNS), and further identify the cellular players involved in mediating acute inflammatory signaling. Gene expression profiling on the cerebral vessels isolated from the brains of the mice treated with peripheral lipopolysaccharide (LPS) revealed that the cerebral vasculature …