Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"glial activation"”.
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Glial activation in a mouse model of endometriosis and impact of Di(2-ethylhexyl) phthalate on glial cells, ileum, and colon
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Pathogenic impact of immune-related cells in Batten disease
… diseases of children. In all types of NCL glial activation, the innate immune response of the brain, precedes neurodegeneration. However, it is unclear whether adaptive immune responses are also involved in these diseases, or if they directly contribute to disease pathogenesis. Therefore, …
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… I hypothesized that FUS induced a transient activation of microglia and astrocyte that is consistent with pro-regenerative functions. Firstly, I developed a method, MORPHological assessment of Outlier clusters (MORPHIOUS), to quantify microglial and astrocytic activation. MORPHIOUS is a …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
… (RAG-2-/-) mouse model of immunodeficiency, glial microenvironment responses were significantly impaired. Reconstitution with CD4+ T cells restored glial activation to normal levels. Motoneuron regeneration responses remained unaffected by immune status. These findings indicate that CD4+ T …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of trigeminal nociceptive neurons is not well understood. The goal of my study was to investigate the role of calcitonin gene-related peptide (CGRP) …
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Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
… activating toll-like receptor-4 (TLR4) on glial cells, resulting in a pro-inflammatory state that manifests clinically as increased pain. Here we hypothesise medication overuse headache is a specific form of opioid-induced hyperalgesia, which derives from a cumulative interaction between …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… investigating neuroinflammatory signalling and activation of microglia and astrocytes in the brain. To validate this model of neuroinflammation, OBSCs from neonatal mice were treated with the pro-inflammatory stimulant lipopolysaccharide (LPS) for 24 hours and compared to untreated control …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
… respiratory infection is sufficient to cause glial activation, promote immune cell trafficking to the CNS and trigger pathology in an autoimmune-prone T cell receptor transgenic mouse line. To test this hypothesis we infected 2D2 mice and monitored for symptoms of inflammatory demyelination …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage antigen complex-1, and/or glial fibrillary acidic protein immunoreactivity. Western blotting and immunohistochemistry showed activation of microglial NADPH oxidase and astroglial …
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Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids
… morphine conditioning, reduces morphine-induced glial activation in the nucleus accumbens (NAc), and increases microglial expression of the anti-inflammatory cytokine interleukin-10 (IL-10). The experiments described in this dissertation were thus designed to address if inflammatory signaling in …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… from the interplay of amyloid and tau pathology, glial activation, vascular dysfunction, and systemic influences. This thesis investigates how systemic infection reshapes the molecular architecture of the AD brain and introduces Genedex, a framework to contextualise transcriptional findings within …
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THE ROAD LESS TAKEN: CHARACTERIZING THE TRIGEMINAL NERVE ROUTE OF NEUROINVASION BY RESPIRATORY SARS-COV-2
… pathology, such as inflammatory infiltration, glial activation, or apoptotic cell deaths, which are typically associated with neuroinvasive viral infections. However, our findings indicated a significant induction of inflammatory cytokines, suggesting an active immune response. Additionally, we …
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Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma
… of genes associated with angiogenesis, glial activation, excitotoxicity and neuroprotection in MIO-M1 cells and HORCs. VEGF expression significantly increased in MIO-M1 cells and HORCs treated with full OGD, and VEGF protein was secreted under reduced levels (1.11mMglucose/4%O2). …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… looking into the role select markers play in ONH glial cell activation, a process still not well understood. Candidates for this work will be prioritized based on novelty and relevance to mechanisms of cellular stress and death. We hypothesize that study of these molecular pathways will provide …
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Near-Infrared Light Reduces Glia Activation and Modulates Neuroinflammation in Brain of Diet-Induced Obese Mice
… performed on brain slices to evaluate glial activation revealed that in both hippocampus and parietal/occipital cortex, HFD caused increased expression of CD68 (activated microglia) and GFAP (astrocytic marker), whereas NIR light reverses this increase. On the other hand, the same …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… models have indicated substantial involvement of glial cells in chronic pain. Although injury models have shown activation of both astrocytes and microglia following insult, research in other CIPN models has shown astrocytic activation in the absence of microglial activation. The central …
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Attributes of Astrocyte Response to Mechano-Stimulation by High-Rate Overpressure
… oxidative stress, edema and persistent glial activation. These features of the injury have emerged as important mediators of the chronic brain damage that results from blast. Astrocytes have emerged as a potential therapeutic target because of their ubiquitous roles in brain homeostasis, …
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Effects of Dip-coated films on the Properties of Implantable Intracortical Microelectrodes
… This RTR culminates in the formation of a tight glial scar and a loss of neuronal density around implanted ICMs, and is accompanied by a decrease in signal to noise ratio and an increase in impedance. While no comprehensive mechanistic understanding of the underlying biology is currently agreed …
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THE ROLE OF P2X7R IN METHAMPHETAMINE-INDUCED BEHAVIORAL CHANGES AND MICROGLIAL EFFECTOR FUNCTIONS
… mediators of the neurological side effects. Upon activation, microglia undergo a morphological change to an amoeboid shape with increased capacity for migration, phagocytosis and cytokine production. Although the initial microglial activation is poorly understood, METH-induced microgliosis …
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