Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 247 for “"glia"”.
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Glia-neuron signaling
… deals with release of neurotransmitter from glia. It has been demonstrated that bradykinin causes a receptor-mediated release of excitatory amino acids (EAAs), glutamate and aspartate, from glial cultures obtained from dorsal root ganglia (DRG) together with an increase in the cytoplasmic …
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Axon-glia interactions during central nervous system myelination
Myelination drastically speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… degeneration. Because gp120 induced microglial activation, we further tested the hypothesis that microglia contribute to gp120-induced synaptic degeneration. We found that blockage of microglial activation abolished the synapse loss induced by gp120. Fractalkine (FKN; a.k.a.CX3C ligand-1 …
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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans
… of a compartment defined by the amphid sheath glial cells that envelop these endings. The glia remodel concomitantly with and independently of AWC receptive endings to delimit AWC receptive ending growth. Remodeling of the glia requires the Otd/Otx transcription factor TTX-1, the C2H2 zinc …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… from the coordinated development of neurons and glia. To better understand the processes that enable nervous system development and function we have studied the sensory organs of Caenorhabditis elegans because their anatomy and function are well-characterized. Specifically, we have focused on two …
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Molecular Mechanisms Underlying Stress-Induced Glia Remodeling in the Nematode C. Elegans
… sensory organs, composed of sensory neurons and glia, which initially detect environmental stress. The molecular mechanisms driving cell shape remodeling following environmental stress and the effects of such remodeling on animal survival are not well understood. C. elegans is an excellent model …
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QUANTITATIVE ANALYSIS OF FLUORESCENT IMAGES OF GLIA CELLS USING DEEP NEURAL NETWORKS
… but also another diverse group of cells known as glia. In recent years, there has been a remarkable surge in interest among neuroscientists regarding glia cells due to their crucial role in brain function. Among the various glia cell types, astrocytes, the most abundant, actively participate in …
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Microdomain calcium oscillations in Drosophila glia regulate seizure susceptibility and require NCKX
Glial cells exhibit spontaneous and activity-dependent fluctuations in intracellular Ca²+, yet it is unclear whether glial Ca²+ oscillations are required during neuronal signaling. Somatic glial Ca²+ waves are primarily mediated by the release of intracellular Ca²+ stores, and their relative …
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Radial glia in the developing superior colliculus : evidence for a midline barrier
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1991.
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Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss
… knocking out the twinkle gene from astrocytes, glial cells of the brain, causing spongiotic encephalopathy, astrogliosis and ciliogenesis activation in the mouse brain. This model is created by using a glial fibrillary acid (GFAP) promoter, driving a Cre recombinase that together with LoxP …
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Radial Glia and the Migration of Young Neurons in the Adult Avian Brain
… to GFAP we identified these cells as radial glia. The same antibody also stained a subset of brain astroglia and reacted with non-brain material such as mesenchyme, Sertoli cells and the Z-line of muscle. A weaker reaction was obtained with erythrocytes and some endothelial cells. 40E-C also …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… in intact sensory neurons and their satellite glial cells (SGCs). To examine the impact of suppressing neuronal p75NTR expression on known molecular modulators/regulators of the nociceptive state namely, the sodium channels NaV1.8 and NaV1.9, the nerve growth factor receptor TrkA, the potassium …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
… in a cell type identified as planarian glia from its localization to the axon-rich neuropil, expression of planarian orthologs of astrocyte genes, and branching morphology in close association with neurons. Evidence of both the existence of planarian glia and their regulation by Hedgehog …
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Hedgehog - like Proteins are Involved in a Novel Glia - Neuron Signalling Pathway in C. elegans
… information, and execute appropriate responses. Glia play essential roles in this information transduction, and glia-neuron communication regulates sensation at every step. But despite this centrality of glia in nervous system function, many of the molecular mechanisms through which glial cells …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… within the mouse brain, astrocytes, microglia, and peripheral tissues. We identify a unique role for astrocytes in the DO response to stress, and describe unique regulation patterns for astrocytes and microglia in the DO response to inflammation and glucocorticoids. Finally, using Cre-lox …
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Optimization-Based Methods for Reconstruction and Structural Quantification of Neurons and Glia from Microscopic Images
Structural analysis of neurons and glia based on light and electron microscopic imaging is indispensable for the understanding of the central nervous system and drug development for brain diseases. It requires the accurate reconstruction of the interesting structures and the design of quantitative …
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