Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"gestational day"”.
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Behavioral Changes in Adult C57BL/6J Mice following Prenatal Exposure to Ethanol.
… separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were noted for both the number of …
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Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model
… our MIA model induced with poly I:C injection at gestational day 9.5, we observed increased locomotion and sensorimotor gating and reduced anxiety in 3-month-old male offspring while females showed decreased sensorimotor gating. These effects were not replicated in PTP1B KO mice indicating a role …
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Defining the Transcriptional and Epigenetic Signature of Mouse Embryonic Stem Cells with Compromised Developmental Potency
… was little difference in embryonic death at gestational day e13.5, there was a significant decrease in embryos surviving to gestational day e17.5. Additionally, severe haemorrhaging was observed in all the dead embryos and small foci of haemorrhaging could also be seen in a number of embryos …
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The mechanism of T cell dysfunction induced by Diethylstilbestrol
… thymic cell viability and induced apoptosis at gestational day(gd)-17. Apoptosis was found to involve the death receptor pathway. Additionally,alterations in T cell subsets was most pronounced at gd-17 as well. The HY-TCR tgmouse model showed that DES exposure altered both positive and negative …
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The effect of non-weight-bearing exercise and protein intake during pregnancy on maternal and fetal zinc content in the Sprague-Dawley rat
… to swim continuously for one and one-half hours/day until sacrifice. The four major groups were further subdivided into 28 groups, designated by three-day intervals according to gestational day--days 3, 6, 9, 12, 15, 18, and 21. Uterine tissues were retained for zinc content analysis; fetal and …
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Exploring the effects of maternal immune activation on cisplatin-induced toxicities.
… fatigue and affective problems in adulthood. On gestational. Day 12.5, dams were injected with 20 mg/kg Poly(I:C) or vehicle. At six weeks old, offspring were single housed with running wheels and 14 days later were injected with saline or cisplatin (2.3 mg//kg/day for 5 days). After cisplatin …
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The Effects of Dietary Fructose and Fat on the Reproductive Parameters of Prepubertal and Pregnant Gilts
… differ amongst any of the five treatments on the day of sacrifice (P=0.32). As a percentage of BW, total reproductive tracts were heavier in fructose fed gilts (1.3±0.1 v. 0.8±0.1%; P=0.01) compared to non-fructose gilts. In the second experiment, starting at 130d of age, gilts were checked twice …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… injected into pregnant Long-Evans (LE) dams on gestational day (GD) 15. Dams were also treated with the three injections of CXCL8(3–72)K11R/G31P (G31P) (500 µg/kg, i.p.), a chemokine receptor antagonist that binds CXCR1 and CXCR2 with high affinity. PolyI:C treatment significantly increased …
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Study on the development of the mouse ossicles using Micro-CT
… five temporal bones of BALB/c mice, aged from gestational day 11 to postnatal day 21 and adult, were enrolled. Three-dimensional high-resolution reconstructions of the ossicles of the left sided temporal bones were obtained using a Micro-CT system. The right sided temporal bones were used for …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… First, using a primary cell culture derived from gestational day (GD) 14 fetal livers, exposure to BQ for 24 hours showed a concentration-dependent decrease in topo IIα activity, which was not protected by treatment with N-acetylcysteine. BQ exposure (12.5 µM) is sufficient to increase topo …
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Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species
… tested in C57BL/6 mice. TCDD was administered on gestational day 14 and pup thymocytes were studied for apoptosis on postnatal days 2, 4, 7, 14, and 21. Perinatal exposure to TCDD decreased thymic cellularity and induced apoptosis in the thymocytes of the pups. Amphibians from polluted areas of …
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Neural tube defects in rodents caused by a tap water contaminant
… the NTDs were pathological being present on both gestational day 9 and 10. We also found that a second species, rats, developed NTDs when exposed to tap waters. Disinfection by-products (DBPs) arise when natural organic matter in municipal water sources reacts with disinfectants used in the water …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… CD-1 mice were dosed with 400 mg/kg of VPA on gestational day (GD) 9 and ultrasounds were performed on GD 14 to 18, prior to harvesting the fetal hearts on GD 19. Using high-resolution ultrasound (HRUS) technology, we examined the effects of VPA on cardiac contractile function, followed by …
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The Effect of Aberrant Inflammation During Pregnancy on Subsequent Risk of Maternal Metabolic Disease Development
… to induce inflammation to pregnant mice on gestational day (GD) 10.5, resulting in total fetal loss. Starting on GD 24.5, the mice consumed a HFD for 10 weeks, being weighed every 2-3 days. Mice were then given an intraperitoneal glucose tolerance test (IPGTT) to assess glucose metabolism. …
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Effect of Inflammation in Pregnancy on Maternal and Offspring Cardiovascular Systems
… (LPS, 50 µg/kg) to induce complete fetal loss on gestational day (GD) 10.5. Fourteen days later, mothers were transitioned to a high fat diet (60% kcal from fat) for 10 weeks. In the offspring study, pregnant Wistar rats were injected i.p. with low dose LPS (10 µg/kg) on GD 13.5 and higher dose …
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The Effect of Resveratrol on Lipopolysaccharide-induced Dopaminergic Deficits and BV-2 Cell Activation
… (i.p.) injection 10, 000 EU/kg LPS at gestational day 10.5 (E10.5) and were fed a resveratrol-enriched diet for 20 days (E3 - E22.5). LPS-induced dopaminergic deficits in pups exposed prenatally at postnatal day 21 (P21), but not at P10 or P40. These deficits were exhibited by a loss of …
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Alterations in Uterine and Placental Sodium Pump Abundance May Contribute to the Onset of Mouse Labor
… Animals (n=4) were sacrificed at specific gestational time points. Other mice had labor induced with LPS on Gestational day 15 and were then studied at specific time points after induction. Specimens were studied for mRNA abundance as well as protein abundance using methods such as Real …
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Effect of a maternal inflammatory challenge during the preimplantation period on offspring development and phenotype
… Infection and injury are common in everyday life and normally result in altered homeostasis and generation of an inflammatory response. The aim of my thesis was to study the effects of an inflammatory environment during preimplantation development on the phenotype of the blastocyst, fetus …
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Perinatal high-fat diet and Bisphenol A: effects on behavior, gene expression and neuroanatomy in the medial prefrontal cortex
… development. Zero (control), 40 or 400 μg/kg/day BPA was orally dosed to pregnant dams from gestational day 2 through birth, and then directly to each pup from postnatal day 1-10. The dams were fed either a control (15.8% kcal/fat) or a high fat diet (45% kcal/fat) during the same time period. …
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Epigenetic Response to Low-Dose Ionizing Radiation
… of X-ray radiation ranging from 0-10.0 cGy on gestational day 4.5. Using a phantom mouse model, the intrauterine doses were estimated to be 0.0 cGy, 0.4 cGy, 0.7 cGy, 1.4 cGy, 3.0 cGy, and 7.6 cGy, respectively. At weaning, offspring coat colors were assessed and tissues were collected for …
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