Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"germline stem cell"”.
-
Characterization of Factors Controlling Germline Stem Cell Maintenance in Drosophila Melanogaster
During Drosophila oogenesis, a germline stem cell (GSC) divides asymmetrically to produce a renewed stem cell and a differentiated daughter cystoblast (CB) that will progress through the 14 stages of oogenesis to produce a mature egg. A myriad of factors regulate GSC maintenance; extrinsic signals …
-
Analysis of the Role of Piwil2 gene in Tumorigenesis and Germline Stem Cell Metabolisms
Die Gene der piwi Familie werden durch ihre konservierte PAZ und Piwi Domäne charakterisiert und spielen eine wichtige Rolle bei der Stammzellselbsterneuerung , dem RNA silencing und der Translationsregulation in verschiedenen Organismen. Murine und humane Piwil2 Gene, Mitglieder der piwi …
-
Histone Demethylase LSD1 Restricts the Size of the Germline Stem Cell Niche in Drosophila Ovaries
Specialized microenvironments called niches keep stem cells in an undifferentiated and self-renewing state by producing a variety of factors. The size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis. I use the Drosophila female germline as an excellent model …
-
Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary
Germline stem cells (GSCs) receive multiple secreted signals that regulate their fate. How these signals are integrated to balance self-renewal with differentiation are not well understood. Here, we use the Drosophila ovary as a model to understand how signal convergence is achieved. Ecdysone …
-
REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
… for fundamental biological processes such as stem cell maintenance. However, aberrant ROS levels lead to oxidative stress, which is highly associated with various human diseases such as cancer and aging. Here, I examined the effects of redox states on stem cell maintenance, and identified the …
-
Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… patterning events of invertebrates, germline stem cell maintenance, and neuronal growth through deadenylation, inhibition of translational elongation, and allow access of microRNAs to their targets. pumilio proteins have yet to be identified and functionally characterized in the …
-
Drosophila Ovarian Stem Cell Establishment is Regulated by Nuclear Hormone Receptor ftz-f1
Stem cells are a fundamental underpinning of tissue biology. Loss of the self-renewing function of stem cells leads to conditions such as infertility and tissue wasting. Stem cells integrate a variety of signals to maintain their fate and proliferative capacity. Although intrinsic and local cues …
-
Determine the developmental dynamics of primordial follicles in the mouse ovary
… can be regenerated from the purported female germline stem cells in the postnatal mouse ovary. We have created a multiple fluorescent Rosa26rbw/+;Ddx4-Cre germline reporter mouse model for in vivo and in vitro tracing the development of female germline cell lineage. Through live cell imaging …
-
Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
<p>Stem cell niches are highly organized and specialized microenvironments located within specific tissues of both vertebrate and invertebrate organisms [1]. In <em>Drosophila melanogaster</em>, three distinct stem cell niches have been identified within the ovary including the germline stem cell …
-
Studies on the mammalian piRNA pathway in cancer cells
… in animals and is implicated in spermatogenesis, germline stem cell maintenance, and transposon suppression in the germline. In mammals, the latter occurs via de novo DNA methylation of transposons during male germ cell maturation. Available evidence suggests that the Piwi/piRNA pathway may also …
-
Studying the Interaction of RACK-1 and GLD-1 in the Germline of Caenorhabditis elegans
Stem cells are undifferentiated cells that can proliferate to produce more stem cells or differentiate to produce specialized cells. Two gonad arms are present within the germline of the hermaphrodite C. elegans, where proliferating germline stem cells (GSCs) are located at the distal end while …
-
Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… signals coordinates the division of Drosophila germline stem cells (GSCs) and differentiation of their daughter cells to produce viable oocytes. The steroid hormone, ecdysone, is known to promote GSC self-renewal; however, due to lack of compatible genetic tools, potential autonomous roles in …
-
Zur Rolle von Stra8 in pluripotenten Stammzellen
… Stammzellen)- und maGSC (multipoten! t adult Germline Stem Cells)-Zelllinien nachgewiesen werden. Dabei zeigte sich, dass Stra8 in diesen Zellen zum Teil zytoplasmatisch, aber auch intranukleär lokalisiert ist. Es konnte zudem gezeigt werden, dass die Stra8-Expression in pluripotenten …