Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"germline specification"”.
-
Molecular analysis of germ cell specification
… cells (PGCs). PGCs are the first cells in the germline, and their correct specification is essential for the eventual production of gametes (eggs and sperm). Murine PGCs arise as a small population in the post-implantation epiblast in response to external signals, including BMP4 and WNT. …
-
Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… protocol as a proxy for the developing germline, also exhibited hypomethylation of imprinted DMRs and indicated an increased risk of reduced germline specification during development impacting offspring fertility and the health of future generations. Intriguingly, MTX treatment was shown …