Global ETD Search
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Showing 1 to 16 of 16 for “"germline development"”.
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Responses to transposon activity and genome damage during germline development
The germline is the cell lineage that is responsible for the inheritance of genetic information in multicellular eukaryotes. In most animal species, germ cells are set aside from somatic lineages during early embryonic development and follow a unique developmental programme that culminates in the …
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Germline development in Platynereis dumerilii and its connection to embryonic patterning
… I present evidence on the establishment of the germline and its correlation with pluripotency and embryonic patterning in the polychaete Platynereis dumerilii, an emerging model system that is well suitable for comparative developmental studies across Bilateria. In the first section, I describe …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… through the inheritance of germ plasm. Early PGC development is regulated by the genetic program coded by unique maternal factors in the germ plasm. However, the biological functions of these germ plasm components and their molecular mechanisms are poorly understood. We found that Dzip1 …
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Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans
… RNAs (siRNAs). miRNAs are required throughout development, whereas piRNAs and siRNAs are best known for their roles in germline development and genome defense (see Chapter 1 for an overview of piRNA and siRNA pathways). To identify the roles of piRNAs and siRNAs in regulating gene expression in …
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The balance of poly(U) polymerase activity ensures germline identity, survival, and development in Caenorhabditis elegans
… and therefore we were curious about the developmental consequences of such gene regulation. Here, we investigated the roles of three Caenorhabditis elegans proteins, with in vitro PUP activity, in germline development. PUP-1/CDE-1 and PUP-2 are known to target certain classes of small …
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C. Elegans OMA-1 and OMA-2 are Transcriptional and Translational Repressors of Germline Fate
The germline is a very specialized cell lineage for the proper transmission of genetic material through many generations, to ensure flawless perpetuation of the species and life cycles. The germline lineage is set aside as early as embryogenesis and kept quiescent until germ cells are needed for …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… of molecular mechanisms involved in germ cell development is limited to classical genetic model organisms and would benefit from studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their germline …
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Characterization of the Morphology, Composition, and Activity of the Germ Plasm in Nasonia vitripennis
… tested only weakly co-localize with conserved germline-associated proteins. Three-dimensional reconstructions of oosomes at specific pre-blastoderm stage syncytial nuclear cycles suggest they exhibit the liquid/elastic solid-like behaviors of deformation, fragmentation, relaxation, and membrane …
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
… give rise to oocytes form a syncytium called a germline cyst. The mechanisms that regulate germline cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) undergo an asymmetric division, giving rise to a stem cell and a cystoblast that then divides four times to …
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Studying the Interaction of RACK-1 and GLD-1 in the Germline of Caenorhabditis elegans
… cells. Two gonad arms are present within the germline of the hermaphrodite C. elegans, where proliferating germline stem cells (GSCs) are located at the distal end while meiotic cells occur more proximally, eventually differentiating as gametes. The balance between proliferation and …
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Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
… UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs in the miRNA pathway, have been shown to be interdependent in the C. elegans germline. The work described …
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The organization and evolution of heterochromatin in the Anopheles gambiae complex
… also has implications in gene regulation, germline development, and anti-viral immunity. Three candidate genes associated with spermatogenesis and embryogenesis have been identified. These genes showed piRNA enrichment, and upon further analysis show up-regulation after a blood meal is …
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The evolution of ribosomal protein paralogues and their roles in development
… sufficient functional ribosomes is essential for development and homeostasis, and reductions in the abundance of functional ribosomes can lead to developmental diseases known as ribosomopathies. Historically, translation has been viewed as a constitutive process, with ribosomes being machines with …
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Mitotic cell cycle progression and differentiation of germline stem cells in Caenorhabditis elegans
In the C. elegans germline, stem cells make a decision to retain the germline proliferative cell fate or differentiate by entering meiosis. Importantly, this decision must be coordinated with progression through the mitotic cell cycle. Previous work has shown that the conserved GLP-1/Notch …
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Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Somatic regulation of germ cell development in the planarian Schmidtea mediterranea: the role of systemic and local factors
The student, Amir Saberi, accepted the attached license on 2016-07-12 at 15:54.