Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"germinal centre B cells"”.
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Long-read transcriptome profiling of germinal centre B cells
… spliced genes are specific to immune cells, yet the regulation and function of AS during B cell activation remain largely unknown. The activation of naive B cells and the subsequent germinal centre (GC) reaction drive the cascade of reactions resulting in short- and long-term antibody …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B cells. Different latency stages within Burkitt’s Lymphoma B cells are observed due to the expression of resident EBV latency genes. These B cells are …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… a harmless infection in human memory B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines derived from GC B cells are a useful model …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid organs and is responsible for the production of high affinity antibody-producing plasma cells and long-lived memory B cells against antigens such as epitopes of oxidised LDL. Class-switched plasma …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… key differences between classic and ectopic germinal centres which may inform how we can improve medical interventions to enhance humoral protection against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way …
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Elucidating oncogenic mechanisms in human B cell malignancies
… induced cell death in patient-derived pre-B ALL cells; with a higher sensitivity observed in relapse pre-B ALL. I also discovered that a high level of Erk activity is required for proliferation of normal pre-B cells, but dispensable in leukemic pre-B ALL cells. In addition, I found that human B …
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Revealing the role of Gα13 in germinal centre lymphomas
… malignancies, arising from the transformation of germinal centre (GC) B cells. Although potentially curable with immuno-chemotherapy, 40% of DLBCL patient relapse and eventually succumb to their disease. In recent years, large-scale genetic classification studies of DLBCL and BL patient tumours …
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Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
During B-cell immune responses, germinal centre structures are the primary sites of antibody affinity maturation and a common site of B-cell lymphomagenesis. Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… leads to the activation of autoreactive B cells, which may drive IrAE pathology. Considering these gaps in understanding, this thesis aims to study how the B and plasma cell responses to cancer are affected by combination anti-PD-1 + anti-CTLA ICB therapy, predominantly using a mouse model …