Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"germinal centre (GC)"”.
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Early divergent B cell differentiation during antibody responses
… divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying the antigen dose altered the proportion of B cells that entered the extra …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines derived from GC B cells are a useful model for studying early EBV-associated changes …
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Revealing the role of Gα13 in germinal centre lymphomas
… malignancies, arising from the transformation of germinal centre (GC) B cells. Although potentially curable with immuno-chemotherapy, 40% of DLBCL patient relapse and eventually succumb to their disease. In recent years, large-scale genetic classification studies of DLBCL and BL patient tumours …
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Germinal centre autoantibody responses following heart transplantation
… with rejection mediated by long-lasting germinal centre (GC) responses, whose maintenance was dependent upon additional, cognate help from recipient T follicular helper (TFH) cells, and which diversified to encompass responses against vimentin autoantigen. Heart grafts transplanted into …
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Translational regulation in aggressive B-cell lymphomas
The Germinal Centre (GC) reaction is a dynamic process where B-cells undergo recombination and somatic hypermutation of immunoglobulin genes in response to antigen stimulation. This essential component of the adaptive immune system is associated with cycles of intensive proliferation and selection, …
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Long-read transcriptome profiling of germinal centre B cells
… activation of naive B cells and the subsequent germinal centre (GC) reaction drive the cascade of reactions resulting in short- and long-term antibody responses, making the GC crucial for adaptive immunity. However, abnormal function of GC B cells contributes to autoimmune disease and the …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… the two. Here, I establish that the defective germinal centre (GC) reaction in Peyer’s patches in the small intestine of aged mice can be rescued by co-housing of adult and aged mice, and via faecal transfers from adult into aged mice. This demonstrates that the poor GC reaction in aged animals …
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Mapping the spatial organisation of B cells and immune signalling in TNBC to characterise response to immunotherapy
… niches exist in TNBC, and that specifically, Germinal centre (GC) and B activated niche cell densities were a strong predictor of immunotherapy response. Additionally, we found that many B and plasma to TME interactions were also enriched among immunotherapy responders. These findings were …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… B cells suggested that this population may be germinal centre (GC) or memory B cells and their presence in the blood may indicate they are a population of circulating GC B cells. However, further analysis revealed that CD10+CD27+ B cells are phenotypically similar to memory and not GC B cells. …
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Follicular Regulatory T cell migration and differentiation
The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells …
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Lymphocyte subset variability between human lymphoid tissues
… in abundance between tissues included: germinal centre (GC) B cells, marginal zone (MZ) B cells, IgM-only B cells, IgA+ B cells, follicular helper T cells and regulatory T cells, as well as CD4+ and CD8+ effector memory cells. These differentially abundant subsets were further …
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Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
… MYC-driven lymphoma, which arise from germinal centre (GC) B cells. DDX3X mutations are especially enriched in male patients. In contrast, DDX3Y is never mutated in lymphoma. Previous work in our group showed DDX3X mutant male tumour cells were addicted to ectopic expression of DDX3Y – …
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T cell phenotyping of a mouse model of Activated PI3Kdelta syndrome
… numbers of T follicular helper cells and germinal centre (GC) B cells upon immunisation with a T cell dependent antigen (NP-KLH). Reduced antigen specific IgG1+ cells within GC B cells was detected in mice harbouring hyperactive p110delta mutation in B cells, implying that the antibody …
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa Silva Cayetano Vaccination efficacy is reduced in older individuals due to diminished immune system function with advancing age. The germinal centre (GC) response plays a crucial role in generating …
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Single Cell Analysis of B Cell Responses to Malaria
… It is known that the generation of a functional germinal centre (GC) to produce affinity matured long lived plasma cells (LLPCS) and memory B cells (MBCS) is crucial for the formation of life-long immune memory. However, there is still relative controversy over what factors influences the …
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Single Cell Analysis of B Cell Responses to Malaria
… It is known that the generation of a functional germinal centre (GC) to produce affinity matured long lived plasma cells (LLPCS) and memory B cells (MBCS) is crucial for the formation of life-long immune memory. However, there is still relative controversy over what factors influences the …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… favoured at the expense of B cells entering the germinal centre (GC) during the early stages of GC formation, compared to those from young donors. Nevertheless, by the peak of the GC response, GC B cells derived from B cells of aged mice had expanded to the same extent as those from the younger …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… by the mantle zone (MZ) B cells and not the germinal centre (GC) B cells. However in CLL lymph nodes complete obliteration of the normal tissue architecture and a weak expression of CD180 has been detected, whilst expression of CD180 on bone marrow CLL cells was heterogeneous. Since CLL cells …
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
… proliferation. However, it is not expressed on germinal centre (GC) B cells. CD180 is expressed heterogeneously on CLL cells, and predominantly on CLL with mutated IGVH genes (M-CLL). Although approximately 60% of CLL clones expressed CD180, only half responded to ligation with anti-CD180 …
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Lymphoma: Understanding the diagnostic challenges and improving outcomes in a TBand HIV-endemic area
… there was a similar distribution of germinal centre (GC) and activated B cell (ABC) subtypes in the HIV-infected and HIV-uninfected groups. In contrast to what is reported in HIV-negative DLBCL literature, there were no statistically significant differences in overall survival by …