Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"germinal centre"”.
-
Germinal centre autoantibody responses following heart transplantation
… with rejection mediated by long-lasting germinal centre (GC) responses, whose maintenance was dependent upon additional, cognate help from recipient T follicular helper (TFH) cells, and which diversified to encompass responses against vimentin autoantigen. Heart grafts transplanted into …
-
Revealing the role of Gα13 in germinal centre lymphomas
… malignancies, arising from the transformation of germinal centre (GC) B cells. Although potentially curable with immuno-chemotherapy, 40% of DLBCL patient relapse and eventually succumb to their disease. In recent years, large-scale genetic classification studies of DLBCL and BL patient tumours …
-
Long-read transcriptome profiling of germinal centre B cells
… activation of naive B cells and the subsequent germinal centre (GC) reaction drive the cascade of reactions resulting in short- and long-term antibody responses, making the GC crucial for adaptive immunity. However, abnormal function of GC B cells contributes to autoimmune disease and the …
-
Age-associated Changes in the Germinal Centre Response Upon Vaccination
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa Silva Cayetano Vaccination efficacy is reduced in older individuals due to diminished immune system function with advancing age. The germinal centre (GC) response plays a crucial role in generating …
-
Modelling the affinity maturation of B lymphocytes in the germinal centre
… the affinity maturation of B lymphocytes in the germinal centre in 3-D because certain behavioural aspects cannot currently be examined experimentally. The software tool recreates the structure of the germinal centre that enables the B cells to move and interact with other cells inside the …
-
The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… latency genes. These B cells are said to display germinal centre B cell markers and interact with other cells within a germinal centre environment, such as Follicular Dendritic Cells (FDCs) and T cells. EBV latency phenotypes were characterised for the lines used here; these lines were then …
-
Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… the two. Here, I establish that the defective germinal centre (GC) reaction in Peyer’s patches in the small intestine of aged mice can be rescued by co-housing of adult and aged mice, and via faecal transfers from adult into aged mice. This demonstrates that the poor GC reaction in aged animals …
-
A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid organs and is responsible for the production of high affinity antibody-producing plasma cells and long-lived memory B cells against antigens such as epitopes of oxidised LDL. Class-switched plasma …
-
An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
… B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines derived from GC B cells are a useful model for studying early EBV-associated changes …
-
Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… activation markers CD80 and CD86. Intra-tumoural germinal centre frequency was also similar between treatment groups, with IHC analysis of tumour samples showing no evidence of tertiary lymphoid structure formation. Finally, preliminary V(D)J sequencing data of IgD- B cells from an untreated …
-
Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… key differences between classic and ectopic germinal centres which may inform how we can improve medical interventions to enhance humoral protection against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way …
-
Genetic Subclones Identify Phenotypic Variation in Diffuse Large B-Cell Lymphoma
… Four themes (memory B cell, plasma cell, germinal centre identity, and B cell identity) recapitulate B cells blocked in differentiation and account for most of the phenotypic heterogeneity between subclones. Three additional themes (MYC, cell cycle, metabolic) characterise transitory cell …
-
Humoral alloimmunity in cardiac allograft rejection
… the humoral alloimmune response (follicular or germinal centre) on graft rejection.
-
Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
During B-cell immune responses, germinal centre structures are the primary sites of antibody affinity maturation and a common site of B-cell lymphomagenesis. Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced …
-
Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… were indicative of a deficiency in the early germinal centre response. Reduced expression of the IL-6R on the immune cells of individuals with severe obesity suggested a mechanism by which germinal centre responses may be impaired. Loss of IL-6 signalling alone was sufficient in mice to cause …
-
Age-dependent changes in the mouse lymph node and implications for immune responses
… age. As the B cell follicle is the place where germinal centre develops, lack of access to antigen in the B cell follicle could be one of the factors that contribute to diminished germinal centre and antibody responses in ageing. Another key factor of the lymph node microenvironment is the lymph …
-
Early divergent B cell differentiation during antibody responses
… divergent differentiation into plasmablasts or germinal centre (GC) B cells. Heterozygous QMxB6 mice, in which 5% of B cells are specific for the hapten 4-hydroxy-3-nitrophenol (NP), were immunized with NP-Ficoll. Varying the antigen dose altered the proportion of B cells that entered the extra …
-
Regulation of LFA-1 on T cells by phosphoinositide signalling
… Rasa3 deletion in T cells resulted in reduced germinal centre and antigen-specific antibody responses to immunisation, likely as a result of decreased T follicular helper (TFH) cell numbers. The presented results thus describe a novel genetic screen in T cells which has uncovered a critical …
-
Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma
… BCR complex cell surface expression in the germinal centre. These findings have clinical implications for patients receiving POLA-V and further our understanding of a regulator of the immune response.
Page 1 of 3