Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 146 for “"germ cells"”.
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Idenficiation of the zebrafish primordial germ cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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A study of the germ cells of Corymorpha palma
Thesis (M.A.)--University of Kansas, Zoology, 1915. ; Includes bibliographical references.
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Fertility preservation of ovarian germ cells: the horse and deer models
… to uncover several important factors related to germ cells preservation. Horses (Equus ferus caballus) have been proven to be an excellent model for reproductive biology studies with implications for humans. White-tailed deer (Odocoileus virginianus) are one of the most abundant wild species in …
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Transcriptional regulation of the piRNA pathway in animal ovarian germ cells
… networks controlling the expression of the germline piRNA pathway components within the gonads of metazoan species remain largely unexplored. In contrast to the male germline piRNA pathway, which in mice is known to be activated by the testis-specific transcription factor A-MYB, the nature …
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The identification of novel factors required for the development of primordial germ cells
… from arising. Mutations that occur in somatic cells can lead to disease, which may be detrimental to that single individual. However, germ line mutations can be passed on to the next generation. These mutations not only drive genome evolution but can also impair the fitness of the offspring. It …
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The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells
In dieser Arbeit untersuchten wir die Potenz der Primordial Keimzellen (PGCs) zur malignen Transformation unter Verwendung eines transgenen Mausmodell. In diesem Modell verwendeten wir das SV40 large Tumor Antigen (LTA),welcher mit dem Keimzellen alkalische Phosphatase (GCAP) Promotor verbunden …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… development, 2) identify the causes of female germ cell loss in the absence of WNT4/β-catenin signaling pathway, and 3) investigate the molecular connection between Wnt4 and β-catenin. In the first study of determining the functional roles of β-catenin, I generated a transgenic mouse with …
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
… expression pattern that is primary restricted to germ cells and aberrantly re-activated in various cancers. However, further investigation revealed that MAGEs not only drive tumorigenesis, but also regulate pathways essential for diverse cellular and developmental processes. Therefore, MAGEs are …
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Expression and functional analysis of <i>Tex18</i> and <i>Stra8</i> genes in male germ cells
Die vorliegende Arbeit befasst sich mit der Expression und der funktionellen Analyse der beiden Testis- spezifischen Gene Tex18 und Stra8. Die RT- PCR- Expressionsanalyse des Gens Tex18 zeigte eine Expression ausschließlich in männlichen Keimzellen. Außerdem konnte die Expression von Tex18 in …
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INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS
… coordinated mRNA utilization throughout male germ cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into …
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P450 aromatase expression in germ cells and sperm of the adult mouse and rat testis and epididymis
… of substantial interest for years. Testicular germ cells and epididymal sperm have been hypothesized to be capable of synthesizing active P450 aromatase (P450arom), the estrogen synthesizing enzyme. This investigation was undertaken to establish that testicular germ cells and epididymal sperm …
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A role for Dazl in commitment to gametogenic fate in embryonic germ cells of C57BL/6 mice
Germ cells can be defined as the cells that undergo the terminal differentiating process of meiosis. In mice, as XX germ cells enter meiosis around Embryonic days 13.5-14.5 (E13.5-E14.5), they form meiotic figures and down-regulate pluripotency markers. XY germ cells enter proliferation arrest …
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Role of m<sup>6</sup>A RNA "reader" YTHDF2 in Mammalian Germ Cells and Early Embryo Development
RNA modifications affect the processing and metabolism of mRNA which ultimately leads to changes in gene expression. Regulation of gene expression is essential for every tissue and every organism, specifically in cell fate determination. N6-methyladenosine (m6A) is one of the most abundant and …
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Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells
In mouse, germ cells retain expression of the pluripotency markers Oct4 and Nanog longer than any other cells in the body. While somatic cells repress these markers during gastrulation, female germ cells continue to express them until around the time of meiotic initiation. It is not yet clear why …
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Dazl regulates mouse embryonic germ cell development
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the …
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Dynamic epigenetic modifications during human fetal germ cell development
Germ cells are responsible for transferring genetic information from parents to offspring, highlighting the significance of normal germ cell development. Epigenetic modifications, which modify gene expression without changing the underlying DNA sequence, can affect the fate of germ cells. Abnormal …
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The role of retinoic acid in germ cell development in embryonic mouse gonads
Germ cells are the only cell type to undergo meiosis, a specialized cell division process necessary for the formation of haploid gametes. Timing of this process is sex-specific. Ovarian germ cells initiate meiosis during embryonic development, while testicular germ cells initiate meiosis after …
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Discovering GCNA: A Novel Regulator of Germline Genomic Stability
Germ cells transfer genetic information across generations. Any change in germ line DNA is inherited by succeeding generations. Therefore, germ cell DNA must be protected from both internal and external assault. An advantage of sexual reproduction stems from the ability to generate variation by …
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Characterization of germ cell development in free-living and parasitic flatworms
… ensure correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including …
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