Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"germ cell tumors"”.
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Cytogenetic and molecular cytogenetic analyses of untreated testicular germ cell tumors
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Cytogenetic studies of testicular germ cell tumors with chromosome 12 specific DNA probes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
Germ cell tumors (GCTs) affect infants, children and young adults and are increasing in incidence worldwide. GCTs arise from pluripotent germ cells and can exhibit differentiated and undifferentiated histologies, which vary in their malignant potential and response to treatment. The pathways that …
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
Background and Objectives Testicular Germ-cell Tumour (TGCT) is the most frequent tumour in the young male and its occurrence is increasing in Europe. Prognosis is favourable, and TGCT basically represents a model of curability of solid tumours. However, clinical management and follow-up of both …
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Toward an epigenetic classification of human testicular germ cell tumors (TGCTs): preliminary assessment of histone H3-K27 trimethylation according to TGCT subtype, aggressiveness, and response to therapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
Testicular germ cell tumors are the most common malignancy found in young men between the ages of 14-40. While these tumors are highly curable with cisplatin based combined chemotherapies, the treatments come with very detrimental side effects and ultimately fail in up to 15% of patients. These …
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Ανοσοϊστοχημική μελέτη της έκφρασης των οιστρογονικών υποδοχέων στους όγκους των ωοθηκών με μονοκλωνικά αντισώματα (με την μέθοδο αβιντίνης-βιοτίνης)
… were localized in 35% of cystadenomy in 67% of tumors of borderline malignancy and in 66% of carcinomas; also in 67% of sex cord-stromal tumors, in 29% of germ cell tumors and in 33% of metastatic tumors, while they were not detected at all in ovarian cysts. We conclude that ER-positive ovarian …
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Testicular cancer – response adapted treatment, prognostic markers and survivorship issues
… in patients with testicular non-seminomatous germ cell tumors (NSGCT). Low RBM3 expression was a predictor of treatment failure in metastatic NSGCT, in relation to the prognostic factors included in the International Germ Cell Consensus Classification (IGCCC). These findings suggest that RBM3 …
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The Role of HNF4A in Germ Cell Tumor Development
Yolk sac tumor is a histological category of germ cell tumors, which represent the most frequent malignancy in young men. Little is known about the molecular mechanisms responsible for the aberrant differentiation and oncogenic potential of yolk sac tumors. Multiple recurrent chromosomal copy …
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Infertility and infertility treatment: childhood cancer and epigenetic risks.
… childhood cancer diagnoses: infant leukemia and germ cell tumors (GCT). As these two diagnoses are quite rare, few previous studies have been performed to examine infertility or its treatment as a possible risk factor. Overall, no significant associations between infertility or its treatment and …
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The Role of Stra8 in spermatogenesis : regulation of spermatogonial differentiation, meiotic initiation, and testicular tumor formation
… during mammalian spermatogenesis. These germ cell transitions include the transition from undifferentiated spermatogonia to differentiating spermatogonia, which continue to proliferate mitotically, and the transition from mitosis to meiosis. This work led to questions about the mechanisms …
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Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… signals coordinates the division of Drosophila germline stem cells (GSCs) and differentiation of their daughter cells to produce viable oocytes. The steroid hormone, ecdysone, is known to promote GSC self-renewal; however, due to lack of compatible genetic tools, potential autonomous roles in …
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Investigating the coordination of germline stem cell fate by ecdysone signaling and BMP signaling in the Drosophila ovary
Germline stem cells (GSCs) receive multiple secreted signals that regulate their fate. How these signals are integrated to balance self-renewal with differentiation are not well understood. Here, we use the Drosophila ovary as a model to understand how signal convergence is achieved. Ecdysone …
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Genetic and Biochemical Analyses of the Necessity for Caspase Activation by the CED4-Domain Proteins, APAF-1 and DARK
… a critical step in the induction of programmed cell death, or apoptosis. Understanding of the genetic and biochemical regulation of the mammalian Ced-4 gene, Apaf-1, may be crucial to the understanding of autoimmune diseases, neurodegenerative disorders and cancer progression. Located in …
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Understanding the functions of HMGB proteins in the mechanism of action of cisplatin
… by "shielding" the damaged site from the cellular repair apparatus. This thesis will describe the work in the area of molecular biology and biochemistry to improve our understanding of the functions of HMGB proteins in the mechanism of action of cisplatin. In Chapter 1, the molecular …
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The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells
In dieser Arbeit untersuchten wir die Potenz der Primordial Keimzellen (PGCs) zur malignen Transformation unter Verwendung eines transgenen Mausmodell. In diesem Modell verwendeten wir das SV40 large Tumor Antigen (LTA),welcher mit dem Keimzellen alkalische Phosphatase (GCAP) Promotor verbunden …
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Immunhistochemischer Algorithmus zur Diagnostik maligner Keimzelltumoren des Hodens
Maligne Keimzelltumoren des Hodens sind die häufigsten soliden malignen Tumoren des jungen Mannes und werden in Seminome und Nicht-Seminome unterteilt. Histopathologisch können Nicht-Seminome in embryonale Karzinome, Dottersacktumoren, Chorionkarzinome und Teratome unterschieden werden. Die exakte …