Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"germ cell differentiation"”.
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
Germ cells are the only cells that can give rise to an embryo. During differentiation, female germ cells that will give rise to oocytes form a syncytium called a germline cyst. The mechanisms that regulate germline cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) …
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Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism and/or the health of their offspring. A myriad of molecules such as …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… of the Rhox family, is expressed in primordial germ cells (PGCs) in the developing gonad and the placenta, although the biological function of Rhox6 in determination of PGCs and placental cells remains unknown. To investigate the Rhox6 function, we generated male chimeras by injection of the …
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Characterization of Ataxin 2-Binding Protein 1 During Female Germ Cell Differentiation in Drosophila Melanogaster
The author has also published articles under the name "Omur Yilmaz Tastan" or "Ömür Yilmaz-Taştan".
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Identification of a novel autonomous role for Ecdysone Receptor during Drosophila ovarian germ cell differentiation
… signals coordinates the division of Drosophila germline stem cells (GSCs) and differentiation of their daughter cells to produce viable oocytes. The steroid hormone, ecdysone, is known to promote GSC self-renewal; however, due to lack of compatible genetic tools, potential autonomous roles in …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
Testicular germ cell tumors are the most common malignancy found in young men between the ages of 14-40. While these tumors are highly curable with cisplatin based combined chemotherapies, the treatments come with very detrimental side effects and ultimately fail in up to 15% of patients. These …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… of molecular mechanisms involved in germ cell development is limited to classical genetic model organisms and would benefit from studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their …
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Dazl regulates mouse embryonic germ cell development
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the …
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
Germ cell tumors (GCTs) affect infants, children and young adults and are increasing in incidence worldwide. GCTs arise from pluripotent germ cells and can exhibit differentiated and undifferentiated histologies, which vary in their malignant potential and response to treatment. The pathways that …
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Genetic Interactions of Factors That Regulate Alternative Rna Splicing In The Male Germ Line of Drosophila
… to protein functions, and further controls cell differentiation and normal development. Although it is known that most eukaryotic genes produce multiple transcripts in which splice site selection is regulated, how RNA binding proteins cooperate to activate and repress specific splice sites …