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Showing 1 to 20 of 42 for “"germ cell development"”.
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Dazl regulates mouse embryonic germ cell development
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the …
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Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
… welche generell als Keimgranulate (engl. germinal granules) bezeichnet werden. Es wird angenommen, dass diese Strukturen in posttranskriptionaler Regulation (inklusive Regulierung durch microRNAs) involviert sind. Interessanterweise, Dead end, ein Komponent von Keimgranulaten, ist …
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Dynamic epigenetic modifications during human fetal germ cell development
Germ cells are responsible for transferring genetic information from parents to offspring, highlighting the significance of normal germ cell development. Epigenetic modifications, which modify gene expression without changing the underlying DNA sequence, can affect the fate of germ cells. Abnormal …
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MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT
… Cytoplasmic Ccnb3 was not required for embryonic development, and its function in ZGA is not conserved. In Chapter 4, we used varied approaches (microscopy, mating tests, histology, Western blot), to explore the function of the coiled-coil protein FLACC1. FLACC1, a testis-specific protein, was …
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Characterization of germ cell development in free-living and parasitic flatworms
… ensure correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including …
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
Germ cells are single-handedly responsible for the transmission of genetic and epigenetic information (the instructions to make new life) from one generation to the next. It is therefore, of paramount importance that germ cells maintain the stability of their genome. Failure to do so can result in …
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DNA Translesion Synthesis Factors are Essential for Mammalian Embryonic Germ Cell Development
Germ cells are responsible for the transmission of genetic and epigenetic information between generations and hence alterations to the genome can have effects across generations. Faithful propagation of the genome is therefore of unique importance as mutations in the germline are the source of …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… of molecular mechanisms involved in germ cell development is limited to classical genetic model organisms and would benefit from studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their …
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The role of retinoic acid in germ cell development in embryonic mouse gonads
Germ cells are the only cell type to undergo meiosis, a specialized cell division process necessary for the formation of haploid gametes. Timing of this process is sex-specific. Ovarian germ cells initiate meiosis during embryonic development, while testicular germ cells initiate meiosis after …
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The role of mir-290-295 in murine embryonic and germ cell development
… specifically in early embryos and embryonic germ cells. This thesis examines the in vivo consequences of targeted deletion of mir-290-295 in the developing mouse embryo. Mir-290-295 deficiency results in a partially penetrant embryonic lethality. Mir-290-295 is not required for early …
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Functional analysis of the Argonaute family proteins during early embryonic and germ cell development in the mouse
… with PIWI proteins to silence transposons in the germ line.<br/>In mammals, genetic experiments revealed that Ago2 is the central effector for both siRNA and miRNA silencing pathways in several developmental processes. Phosphorylation of serine 388 of murine protein is dependent on the MK2 and …
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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo
<p>The specification of germ cells during embryonic development is vital not only for the development of an organism, but quite literally for the survival and propagation of its entire species. Recent work has demonstrated that several aspects of human primordial germ cell (hPGC) development are …
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Somatic regulation of germ cell development in the planarian Schmidtea mediterranea: the role of systemic and local factors
The student, Amir Saberi, accepted the attached license on 2016-07-12 at 15:54.
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Developmental transitions of germ cell lineage of the mouse
Mammalian germ cells arise during early embryogenesis and migrate to the developing gonad where, under the direction of the somatic environment, they initiate distinct sex-specific developmental programs resulting in the production of egg or sperm. Our understanding of the molecular mechanisms …
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Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism and/or the health of their offspring. A myriad of molecules such as …
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Molecular Dissection of a Caenorhabditis Elegans Germ Granule Assembly Protein to Determine Its Role in Cell Development
In metazoans, germ cells play a fundamental role in ensuring the continuity of animal life. Germ cells contain germ granules, cytoplasmic non-membrane bound organelles also referred to as RNA-protein condensates. These germ granules house a variety of RNAs and proteins essential for germline …
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Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells
In mouse, germ cells retain expression of the pluripotency markers Oct4 and Nanog longer than any other cells in the body. While somatic cells repress these markers during gastrulation, female germ cells continue to express them until around the time of meiotic initiation. It is not yet clear why …
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In vitro studies on genotoxicity and gene expression in spermatogenic cells: mechanisms and assay development
Spermatogenesis is a complex process of male germ cell development from diploid spermatogonia to haploid fertile spermatozoa. Apoptosis plays a vital role in limiting cell numbers and eliminating defective germ cells. This requires novel gene products, and precise and well-coordinated programmes of …
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Characterization of the hermaphroditic reproductive system and sexual development in the planarian Schmidtea mediterranea
… mechanisms, as well as different modes of germ cell development, there is one clear goal – to produce new offspring with unique genetic makeup. Scientists have long been intrigued by this diversity, and biologists today are delving deep into the molecular mechanisms underlying the variety …
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Esx1 Dosage Impacts Reproductive Fitness: Effects On Viability and Fertility
… inactivation in placenta and MSCI in testicular germ cells). When the X-chromosome is duplicated or improperly inactivated, defects in placentation, growth and spermatogenesis are noted, suggesting tight control of X-chromosome gene dosage is important for reproduction. Esx1 is a mouse homeobox …
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