Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"germ cell"”.
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
Germ cell tumors (GCTs) affect infants, children and young adults and are increasing in incidence worldwide. GCTs arise from pluripotent germ cells and can exhibit differentiated and undifferentiated histologies, which vary in their malignant potential and response to treatment. The pathways that …
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Molecular analysis of germ cell specification
… is the correct differentiation of primordial germ cells (PGCs). PGCs are the first cells in the germline, and their correct specification is essential for the eventual production of gametes (eggs and sperm). Murine PGCs arise as a small population in the post-implantation epiblast in response …
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Dazl regulates mouse embryonic germ cell development
In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been well studied. The earliest known sex-specific difference in germ cells is the …
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Targeting oncogenic microRNAs in malignant germ cell tumours.
Malignant germ cell tumours (mGCTs) are a heterogenous group of tumours that occur primarily in the testes and ovaries but also in other anatomical sites, and affect people of all ages. It was established by the Coleman group through microRNA profiling in 2010 that all mGCTs, regardless of tumour …
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The Role of HNF4A in Germ Cell Tumor Development
Yolk sac tumor is a histological category of germ cell tumors, which represent the most frequent malignancy in young men. Little is known about the molecular mechanisms responsible for the aberrant differentiation and oncogenic potential of yolk sac tumors. Multiple recurrent chromosomal copy …
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Rbfox1 Regulates mRNA Translation to Promote Germ Cell Differentiation
Germ cells are the only cells that can give rise to an embryo. During differentiation, female germ cells that will give rise to oocytes form a syncytium called a germline cyst. The mechanisms that regulate germline cyst development remain poorly understood. In Drosophila, germline stem cells (GSCs) …
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Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
… welche generell als Keimgranulate (engl. germinal granules) bezeichnet werden. Es wird angenommen, dass diese Strukturen in posttranskriptionaler Regulation (inklusive Regulierung durch microRNAs) involviert sind. Interessanterweise, Dead end, ein Komponent von Keimgranulaten, ist …
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Dynamic epigenetic modifications during human fetal germ cell development
Germ cells are responsible for transferring genetic information from parents to offspring, highlighting the significance of normal germ cell development. Epigenetic modifications, which modify gene expression without changing the underlying DNA sequence, can affect the fate of germ cells. Abnormal …
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Developmental transitions of germ cell lineage of the mouse
Mammalian germ cells arise during early embryogenesis and migrate to the developing gonad where, under the direction of the somatic environment, they initiate distinct sex-specific developmental programs resulting in the production of egg or sperm. Our understanding of the molecular mechanisms …
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Signalling and transcriptional regulation of human primordial germ cell specification
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation human embryos, which are inaccessible for direct investigation. This process can however be modelled using human embryonic stem cells (hESCs) for in vitro derivation of human PGC-like cells (hPGCLCs). …
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Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
… – the physical separation of daughter cells following chromosome segregation. Anillin binds filamentous F-actin, non-muscle myosin II and septins, and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this …
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Characterization of the Beta-Karyopherin Protein Ipo9 During Germ Cell Differentiation
Germ cells participate in the most fascinating process in nature, the fusion of two cells that ultimately give rise to an entire organism. Errors in germ cell development directly affect the fertility of the parent organism and/or the health of their offspring. A myriad of molecules such as …
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BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
Testicular germ cell tumors are the most common malignancy found in young men between the ages of 14-40. While these tumors are highly curable with cisplatin based combined chemotherapies, the treatments come with very detrimental side effects and ultimately fail in up to 15% of patients. These …
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MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT
… Together, this work provides insights into the germ cell-specific function of three conserved genes, two of which are required for mammalian fertility.
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Cytogenetic and molecular cytogenetic analyses of untreated testicular germ cell tumors
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of germ cell development in free-living and parasitic flatworms
… ensure correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including …
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Dynamics of Germ Cell Specific Stable Transcriptional Complexes in Xenopus Oocytes
… is particularly true of genes that determine cell fate; for example, Asc1-1 leads to neural differentiation and MyoD for muscle. In early development, different genes need to be activated in sequence by appropriate transcription factors. It is commonly believed that a transcription factor has …
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A Novel Transgenic Rat Model for the Study of Germ Cell Biology
… a transgenic line of rats expressing GFP in all cells of the body, a serendipitous integration of a ROSA-EGFP transgene resulted in exclusive expression of EGFP in the germ cells of both sexes. EGFP expression was uniform and robust in cleavage stage embryos beginning at the late 2-cell stage and …
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Molecular Characterization of the Male Germ Cell Expressed Genes Hook1 and TSEP22
Im Rahmen dieser Arbeit wurden die murinen Gene Hook1 und TSEP22 molekulargenetisch charakterisiert. Beide Gene werden in männlichen Keimzellen exprimiert und das Vorkommen der Hook1 und TSEP22Genprodukte in elongierten Spermatiden lässt vermuten, dass beide Gene eine Rolle bei der Reifung bzw. für …
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