Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"geranylgeranylpyrophosphate"”.
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… to lovastatin's ability to block formation of geranylgeranylpyrophosphate and farnesylpyrophosphate by interfering with the rate-limiting step of the mevalonate pathway. Geranylgeranylpyrophosphate and farnesylpyrophosphate induce post-translational modifications in RAS that anchor the protein …
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
… potentiation. In parallel, we demonstrate that Geranylgeranylpyrophosphate (GGPP) can function as a novel SOCE inhibitor either by saturation or prevention of transfer to membrane proteins; both of which lead to GGPP accumulation in the cytosol. Collectively, we provide evidence that Ca2+ …