Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"geranylgeranylation"”.
-
Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
… our current techniques into the realm of geranylgeranylation in order to study the enzymatic requirements of GGTase-I, but also on developing cellular probes that would allow for the identification of geranylgeranylated proteins.</p> <p>The initial goal of this project was to advance our …
-
Prognostic Markers and Mechanisms of Chemotherapy Resistance in Diffuse Large B-cell Lymphoma
… model, showed that treatment with geranylgeranylation inhibitors in DLBCL cell lines had a chemo-sensitising effect. This indicates that inhibition of geranylgeranylation may prove a useful strategy for overcoming CHOP resistance in DLBCL. A recombinant antibody microarray was used …
-
Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… is mimicked by a specific inhibitor of protein geranylgeranylation.</p><p>Our novel findings suggest that TNF-α-mediated migration of autoreactive leukocytes into peripheral nerves during EAN proceeds, in part, by a mechanism that involves geranylgeranylation-dependent secretion of MCP-1. We …
-
On connections between metazoan cellular metabolism and cell size
… of the mevalonate pathway revealed that protein geranylgeranylation is required for maintaining normal cell size and proliferation ratio. Geranylgeranylation of the recycling endosome regulating protein RAB11 was identified to be at least partially responsible for the cell size regulation by the …
-
Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
… cardial cell-autonomous requirement of Ggamma 1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease. In addition, we found that the heterotrimeric G proteins Gbeta 13F and G-oalpha 47A together with the RGS (regulator of G …
-
EXPANDING THE POTENTIAL PRENYLOME: PRENYLATION OF SHORTENED TARGET SUBSTRATES BY FTASE AND DEVELOPMENT OF FRET-BASED SYSTEM FOR DETECTING POTENTIALLY “SHUNTED” PROTEINS
… promiscuity leading to both farnesylation and geranylgeranylation of these sequences. The work herein expands the substrate pool of sequences that can be potentially prenylated, further refines our understanding of substrate recognition by FTase and GGTase-I and suggests the possibility of a …
-
Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… of the enzymes that mediate farnesylation and geranylgeranylation (encoded by Fntb and Pggt1b, respectively) leads to a reduction of eTreg cells and the development of fatal autoimmunity. In Chapter 4, we further explored the mechanistic role of protein prenylation in the regulation of eTreg …
-
Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
Rho family guanine nucleotide triphosphatases (GTPases) are molecular switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream effectors. Small GTPases are considered active when bound to guanosine …
-
Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
Malaria kills at least one million people each year, mostly children - a death every 30 seconds. Almost one half of the world population is at risk from malaria. Antimalarial drugs are the only means for the treatment of about 500 million annual global malaria cases. Because of prevalent …