Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 110 for “"gentamicin"”.
-
Enzymology of Gentamicin Biosynthesis
Gentamicin C complex is a mixture of five structurally similar aminoglycoside antibiotics, gentamicins C1, C1a, C2, C2a, and C2b, produced by the actinomycete bacterium Micromonospora echinospora. It is established in clinical use and despite significant toxicity remains valuable to treat severe …
-
Antimicrobial pharmacodynamics: The gentamicin - Escherichia coli relationship
… the in vitro dose-response relationship between gentamicin and Escherichia coli under conditions of constant and declining antibiotic concentrations and (2) to characterize the kinetics of the relationship in an attempt to better predict antimicrobial efficacy. A unique in vitro dynamic culture …
-
Time and Concentration Relationships of Gentamicin in Serum and Bronchial Lavage Fluid of Horses Administered Gentamicin Intravenously and by Aerosol
… to compare the delivery of the antimicrobial gentamicin to the respiratory tract of adult horses following aerosol and intravenous administration. Nine adult horses were used in a crossover design. Aerosol administration of gentamicin was performed using a close fitting facemask and an …
-
Elution of Metronidazole and Gentamicin from Polymethylmethacrylate Beads
… containing metronidazole (3 concentrations); gentamicin sulfate; or metronidazole and gentamicin sulfate were immersed in 5 ml of phosphate buffered saline in triplicate. Eluent was replaced at specified time intervals for 1 day (1, 3, 6, 12 and 24 hours), daily, or weekly for 21 days. …
-
Gentamicin-PMMA beads: a clinical, pharmacokinetic and toxicological study
Contains fulltext : mmubn000001_027398811.pdf (Publisher’s version ) (Open Access)
-
Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
Gentamicin is a broad-spectrum, bactericidal antibiotic of the aminoglycoside family. It has been shown through extensive evaluation to be effective in the treatment of serious gram- negative bacillary infections (1-5). Gentamicin is one of the few antimicrobial agents available for the treatment …
-
Gentamicin and FM1-43 enter sensory hair cells through mechanosensory transduction channel
… through the transduction channels. Both gentamicin, an aminoglycoside, and FM1-43, a styryl pyridinium dye, rapidly and selectively enter hair cells. The hair cell transduction channel passes monovalent cations, but is selective for the divalent calcium. FM1-43 and gentamicin are larger …
-
Controlled release of gentamicin from polyelectrolyte multilayers to treat implant-related infection
… and release the small, hydrophilic antibiotic gentamicin from implant surfaces for infection control. The use of a cationic hydrolytically cleavable poly(p-amino ester) rendered these films biodegradable, yielding both diffusion-based and surface-erosion based release of this therapeutic. The …
-
Effects of a prostaglandin E₁ analogue, misoprostol, on gentamicin-induced nephrotoxicosis in dogs
… oral prostaglandin E₁ analogue, misoprostol, in gentamicin-induced nephrotoxicosis in dogs. Twelve dogs were initially assessed to be clinically healthy and to have normal renal function. Each received gentamicin (10 mg/kg intravenously, every 8 hours) for 8 days. Six dogs received oral placebo …
-
Development of core-shell nanostructure encapsulating gentamicin as efficient drug delivery system against intracellular Salmonella
… of cell-impermeable aminoglycosides like gentamicin within these cells. In this dissertation, we hypothesize that developing a novel core-shell methodology for incorporating high amounts of gentamicin into the cores with either hydrophilic or amphiphilic shell will be more effective than …
-
Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications
… and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion …
-
Evaluation of amoxicillin, metronidazole and gentamicin dosage regimens for use in antibiotic prophylaxis in colorectal surgery
… developed for amoxicillin, metronidazole, and gentamicin usingNONMEM® in order to determine the probability of maintaining free drugconcentrations above the MIC breakpoints of the following microorganisms:methicillin-sensitive Staphylococcus aureus, Escherichia coli, Bacteroides fragilisgroup, …
-
Deciphering Metabolic Adaptations in Salmonella Enterica Serovar Typhimurium 14028S During Batch Growth and Gentamicin Exposure Using Absolute Quantitative Proteomics
… anabolic or catabolic pathways. In presence of gentamicin, we observed an increase in the abundance of ribosomal proteins, suggesting that S. Typhimurium might compensate for ribosomal inhibition by synthesizing additional ribosomes. Moreover, we observed an increased abundance of proteins …
-
Induktion und Prophylaxe Implantat assoziierter Knocheninfektionen am Modell eines antiinfektiv beschichteten Marknagels
… from a new biodegradable, stable, antibacterial gentamicin-loaded poly-(D,L-lactide) (PDLLA) coating of orthopedic devices. In vitro, elution kinetics of gentamicin and furthermore, biocompatibility and effectiveness in preventing implant-related osteomyelitis should be studied in vivo. Coating …
-
Kapillarelektrophoretische Trennung und Quantifizierung von Aminoglykosiden und Clotrimazol
… Methoden entwickelt, mit denen es möglich ist, Gentamicinsulfat in Haupt- und Nebenkomponenten zu trennen. Ausgelöst wurden die Untersuchungen im Jahr 2000, da in den USA über 60 Patienten durch Gentamicin starben. Es wurde vermutet, dass dies auf Verunreinigungen in gewissen Chargen …
-
Cooperative Electrostatic Polymer-Antibiotic Nanoplexes
… polymeric drug delivery vehicles containing gentamicin to potentially overcome this challenge. Pentablock and diblock copolymers comprised of amphiphilic nonionic polyether blocks and anionic poly(sodium acrylate) blocks have been complexed with the cationic aminoglycoside gentamicin. The …
-
Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
… high concentrations of the cationic antibiotic gentamicin (31 wt%). A near zero-order release of gentamicin (pH 7.4 in PBS) that reached ~35 wt% of the initial gentamicin within 10 hours was observed, and this was followed by slower release of another 7 % by 18 hours. These nanoparticles were …
-
Approaches towards therapeutic development against chronic brucellosis in a mouse model
… tested to treat B. melitensis infection in mice. Gentamicin loaded block-ionomer complexes (BICs) and magnetite block-ionomer complexes (MBICs) were tested in vitro and along with clusters of MBICs (MBIClusters) were tested in vivo as tools to deliver gentamicin intracellularly. While these …
-
The location, expression and regulation of three antibiotic resistance genes in acinetobacter
… from a tracheal aspirate; it is resistant to gentamicin, tobramycin, netilmicin, streptomycin, chloramphenicol and suphamethoxazole. This study examines the nature of the resistance to gentamicin, tobramycin and chloramphenicol at three levels: the biochemical mechanism of resistance, the …
-
The effect of antibiotics on Pseudomonas aeruginosa biofilm production
… be effective at a concentration of 0.07mg/mL for gentamicin, rifampicin, and polymyxin B. These antibiotics were used to test 48 clinical samples obtained in 2006. Out of the 48 isolates, a Pseudomonas strain of unknown origin was resistant to both gentamicin and rifampicin (p<0.001). Extraction …
Page 1 of 6