Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"genotype 1"”.
-
Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… the HVR1 of the N-amino terminal region of E2. Genotypes, subtypes and quasispecies can be distinguished. Quasispecies refer to the genetic diversity of a virus population that can be observed in a single infected individual with individual viral genomes differing 1%-5% in nucleotide sequence. …
-
Extent of genotype-specific humoral immunity produced on infection with hepatitis C virus: relevance for serological screening and diagnosis
… The screening ELISA tests are based upon genotype 1 sequence. Six distinct HCV genotypes exist, which show approximately 30 % amino acid sequence divergence in their encoded proteins. Sequence variability is not uniform across the genome, being greatest in the regions encoding envelope …
-
Molecular epidemiology of human rabies diagnosed in South Africa between 1983 and 2007
… There are two distinct biotypes of lyssavirus genotype 1 circulating in South Africa: a canine biotype circulating in domestic dogs, bat-eared foxes and black-backed jackals and a mongoose biotype circulating in herpestids. The presence of LBV, MOKV and DUVV has been demonstrated in South …
-
Drug resistance mechanisms and drug design strategies for human immunodeficiency virus and hepatitis c virus proteases
… the treatment of patients infected with the HCV genotype 1. The enzyme assays and molecular dynamic studies suggest that telaprevir may retain sufficient potency to treat the non-genotype 1 HCV strains.</p>
-
Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication
… the effect of exchange of HVR among different genotypes on the replication-competency and virion production in vitro. Extensive sequence variability in the HVR among HEV strains of different genotypes prompted us to study the dispensability of this region. Initially we constructed two partial …
-
Characterization of human astrovirus in pediatric patients with diarrhea from rural communities of Limpopo South Africa
… The sequence analyses revealed HAstV genotype 1 and 2. A putative recombinant strain was found. Phylogenetic analysis revealed strain’s relatedness to others circulating in the African continent. Conclusion: This is the first study to characterize HAstVs from pediatric stool sample in …
-
Foodborne Transmission and Molecular Mechanism of Cross-species Infection of Hepatitis E Virus (HEV)
… of global distribution. At least four distinct genotypes of HEV exist worldwide: genotype 1 and 2 HEV strains are responsible for waterborne epidemics; genotype 3 and 4 HEV strains are responsible for sporadic occurrences of acute hepatitis E. Genotype 3 and 4 HEVs are zoonotic and have a more …
-
HCV-Diagnostik mittels genotypspezifischer Antikörper
… diagnostic system to discriminate between HCV genotypes 1b, 2 and 3. The envelope protein E2 sequence of genotype 1b was isolated from patients blood whereas consenus sequences had to be deduced from all available genotype-2 and -3 sequences. Sequences were derived from all sequences available …
-
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
… HCV infection. In a post-hoc analysis of 354 HCV genotype 2/3 infected patients receiving interferon-α and ribavirin, genetic variation in ITPA entailing reduced ITPase activity was associated with increased cure rates (paper I). Small inhibiting RNA aimed at ITPA reduced ITPase levels and …
-
Identification of Host Factors Required for Hepatitis C Virus Infection
… used to study the HCV lifecycle. However, the genotype1 HCV, which is the most difficult strain to treat in clinic, still can not be grown in cultured cells. We found a cell line named HCV Replication Permissive 1 (HRP1) that supports the replication of genotype 1 HCV. Interestingly, HRP1 cells …
-
Identification and characterization of a novel structural protein of porcine reproductive and respiratory syndrome virus, the replicase nonstructural protein 2
… highly divergent stains of PRRSV including the genotype 1 and genotype 2 prototype strains as well as contemporary and highly-pathogenic isolates.</p> <p>Next the hydrophobic domain of nsp2 was characterized as a putative multi-pass transmembrane domain predicted to facilitate nsp2 packaging …
-
Molecular and Serological Epidemiology of Swine Hepatitis E Virus from Pigs in Two Countries
… barrier and infect humans. There are four major genotypes of HEV worldwide and swine HEV identified to date in different countries belongs to either genotypes 3 or 4. Thus far, genotypes 1 (Asian strains) and 2 (a single Mexican strain) of HEV are exclusively found in humans. To determine if …
-
The interaction of hepatitis C virus and intracellular lipid metabolism
… more frequently in patients infected with HCV genotype 3 than those infected with genotype 1 (Mihm et al., 1997). Currently there is no cell-based method of investigating the life cycle of HCV genotype 3 and transgenic mice studies have been restricted to genotype 1 proteins. Three chimpanzees …
-
Molecular investigation of bovine leukemia virus in selected wildlife in Zambia.
… for Animal Health (OIE). There are ten distinct genotypes for BLV, genotype 1-10. While epidemiological studies have shown that BLV infection is present in dairy and beef cattle in Zambia, there has been no studies to detect BLV in wildlife. In this study, 172 archived wildlife blood samples from …
-
Molecular investigation of bovine leukemia virus in selected wildlife in Zambia.
… for Animal Health (OIE). There are ten distinct genotypes for BLV, genotype 1-10. While epidemiological studies have shown that BLV infection is present in dairy and beef cattle in Zambia, there has been no studies to detect BLV in wildlife. In this study, 172 archived wildlife blood samples from …
-
Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus
… geographical regions worldwide with known genotypes were determined. The BLV full-length envelope (env) and gag genes were successfully sequenced from total DNA extracted from the blood of BLV-infected cattle from a single herd. The analyses indicated that the seven of the South African …
-
Genetische Assoziationsstudien der immunologisch relevanten Gene CCR5, CX3CR1 und RANTES zur klinischen Risikostratifizierung von Patienten mit chronischer Hepatitis C
… was also confirmed for patients with the HCV-genotype 1+4. These results suggest that the RANTES-haplotypes might contribute to the complex interaction between the hepatitis C virus and the polygenic determined immune response of the patient receiving antiviral therapy. The results of this …
-
Cross-Species Infection and Characterization of Avian Hepatitis E Virus
… of swine HEV and human HEV. However, swine HEV (genotype 3) and human HEV (genotype 1) ORF3 proteins cross-react with each other antigenically. To determine if the ORF3 protein is a virion protein, infectious stocks of avian HEV and swine HEV were first generated in SPF chickens and pigs, …