Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1262 for “"genotype"”.
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COMT Genotype, Schizophrenia, and Dopamine Transmission
… The current study analyzed the effect of COMT genotype and schizophrenia on the mRNA expression of genes known to be influenced by dopamine signal transmission with qPCR of RNA extracted from high-quality, fresh-frozen postmortem dorsolateral prefrontal cortex tissue. While no significant …
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Genotype and phenotype in mitochondrial disorders
… for 16 mitochondrial genes. We have explored genotypes and phenotypes in mitochondrial disorders considering diagnosis, natural history, and a possible treatment.
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Familial adenomatous polyposis: a genotype - phenotype correlation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Mapping Genotype to Phenotype using Attribute Grammar
… language, we propose to model relations between genotype and phenotype using formal language theory. We use attribute grammars (AGs) to extract context-dependent information from genetic constructs and compile them into mathematical models, possibly giving clues about their phenotypes. They may …
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Genotype by environment model predictive ability in miscanthus
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Exploring Interactions Between DRD4 Genotype and Perceived Parenting Environment
… examined possible interactions between DRD4 genotype and parenting on children’s externalizing, internalizing, and prosocial behaviors, and explored both parent and child perceptions of all variables. Both diathesis-stress and differential susceptibility hypotheses were assessed for examining …
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Mapping Genotype to Phenotype with High-Throughput Empirical Approaches
… a central goal of biology. The structure of this genotype-phenotype map, or landscape, underlies the dynamics of populations adapting under natural selection, and quantitative understanding will be required to predict and engineer outcomes in evolving organisms like viral pathogens, cancer cells, …
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Genotype by feeding regimen interactions in growth selected chickens
… feed consumption was influenced by feathering genotypes and management practices. Increases in hatchability for the initial period after onset of lay were due to a reduction in early embryo deaths. Egg and 18-day embryo weights, ratios of embryo:egg and yolk:albumen, and proficiency of lipid …
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Clustering Single-Cell Electropherograms by Genotype Through Unsupervised Machine Learning
… in the late 1990s it was demonstrated that genotype information could be extracted from individual cells. When used in a forensics context, single-cell methods offer a potential solution to the complex mixture problem by providing genetic information per-cell rather than solely for the whole …
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Plant genotype, immunity and soil composition control the rhizosphere microbiome
… in the mycorrhization ability. All these plant genotypes, except those for methyl-halide production and one genotype involved in PAMP response, significantly altered the rhizosphere microbiome.
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Understanding Alicyclobacillus Spoilage at the Intersection of Genotype and Environment
Food spoilage is a major issue leading to waste, lost revenue, and consumer dissatisfaction. Beverages are known to be spoiled by Alicyclobacillus spp., which are extremophilic sporeformers that cannot be killed by traditional pasteurization methods. The spoilage metabolite guaiacol is only …
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
The PIK3R1 gene encodes three proteins - p85$\alpha$, p50$\alpha$ and p55$\alpha$ - that are regulatory subunits of Class IA phosphoinositide 3-kinases (PI3Ks). These regulatory subunits heterodimerise with one of three catalytic subunit isoforms, namely p110$\alpha$, p110$\beta$, or p110$\delta$. …
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From Phenotype to Genotype: Discovery of New Molecular Primary Immunodeficiencies
Since the 1950s, the investigation of genetic causes of primary immunodeficiencies has fundamentally shaped our understanding of the immune system, and that fountain of knowledge has continued to expand explosively as we enter the genomic era with the dawn of CRISPR and personalized medicine. In …
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Structural Properties of Genotype-Phenotype Maps: Models, Estimates and Evolution
Genotype-phenotype (GP) maps play a crucial role in evolution, as they set up a connection between the space of genotypes, on which mutations take place, and the space of phenotypes, which is affected by selection. This thesis studies a range of questions surrounding the structural properties of GP …
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Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
Lung adenocarcinoma (LUAD) remains the world's leading cause of cancer related mortality with an estimated two-hundred thousand new cases arising in 2019 in the United states alone. Molecular characterization of patient tumors has identified activating mutations in the small GTPase, KRAS, …
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Theileria orientalis Ikeda Genotype: Implications for Cattle Health in Virginia
… complex, in particular the Ikeda and Chitose genotypes. These organisms are carried by the ixodid tick, Haemaphysalis longicornis, recently identified in the United States. Our work has been focused on initially identifying the protozoal organisms, crafting assays to aid in the identification …
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CHROMOSOME AND GENOTYPE CHARACTERIZATION IN SOME RICE BIOTYPES SHOWING GRAIN SHATTERING
Red rice (Oryza sativa var. silvatica L.) is a common weed in rice crop, very troublesome to control due to high shattering. The aim of the present research was to analyse the genome of some biotypes of red rice in order to promote innovatives methods for its control. In the first year, …
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