Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"genotoxicity"”.
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Epigenetic Determinants of CRISPR-Cas9 genotoxicity
… requires bespoke approaches. To assess genotoxicity linked to Cas9-mediated genome editing, the first tool implemented is the Multi-Endpoint Genotoxicity Assessment (MEGA) screen, a high-throughput imaging-based platform designed to identify multiple genotoxicity endpoints. These …
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Human embryonic stem cells for genotoxicity testing
… the utility of hESCs as a cellular model for genotoxicity testing. Chromosomal analysis by PNA-FISH and mFISH following Mitomycin C treatment revealed that hESCs are significantly more resistant to genotoxic damage than normal human fibroblast cell line as evidenced by the lower levels of …
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The Chemical-Induced Genotoxicity of Depleted Uranium
… little is known about the direct chemical genotoxicity of uranium. The overall hypothesis of the current research is that uranium can produce DNA damage by chemical genotoxicity mechanisms. Three specific aims were tested. In Aim 1, specific DNA lesions caused by direct interaction of …
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The role of microbial-mediated genotoxicity during pathogenesis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Hydrogen peroxide-induced genotoxicity and transgenerational implications in sea urchins
… this thesis investigates degradation rates and genotoxicity in sea urchins exposed to environmentally-relevant concentrations of H<sub>2</sub>O<sub>2</sub>. The degradation rate of H<sub>2</sub>O<sub>2</sub> was 1% per day, slower than reported in previous studies which suggested limited …
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Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection by -Products
… quantitative rank order of the cytotoxicity and genotoxicity of the DBPs showed that brominated haloacetic acids were more genotoxic than their chlorinated analogs in mammalian cells. The difference in the responses to DBPs by bacterial and mammalian cells suggests that the relative risks based …
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Genotoxicity associated with nitric oxide production in activated murine macrophages
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1997.
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Mutagenesis and genotoxicity of the major DNA adduct of Cis-diamminedichloroplatinum(II)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1991.
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ASSESSING THE GENOTOXICITY OF TRICLOSAN IN TADPOLES OF THE AMERICAN BULLFROG, LITHOBATES CATESBEIANUS.
… in urban areas. The NIH has pinpointed genotoxicity as a major route of cancer causation, and has since developed stringent testing procedures for potentially hazardous chemicals. One such method, recognized for its simplicity and economy, is the micronucleus assay. A study was conducted …
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Xenobiotic metabolism and markers of genotoxicity in regulatory non-vertebrate ecotoxicological test species
… given to subtle sub-lethal effects such as genotoxicity. Moreover, even less information is available on the responses of lower animals and plants to such substances. In this study, the sub-lethal responses of the water flea Daphnia magna, and the unicellular alga Chlamydomonas reinhardtii …
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In vitro studies on genotoxicity and gene expression in spermatogenic cells: mechanisms and assay development
… germ cells seem to be a suitable model to study genotoxicity in vitro yielding result comparable to those reported in vivo. Furthermore, the work shows that genotoxins can impair gene expression.
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
… human cells and thus provide a highly predictive genotoxicity assay. As first steps in developing a toxicity assay, this thesis work (a) adapted a fetal liver-based in vitro erythropoietic culture system to induce optimized erythropoietic growth from the lineage-marker-negative (Lin) population in …
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Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes
… cancer has been established, the mechanisms of genotoxicity in inflammatory environments remain poorly understood. We hypothesized that inflammation may provide cues that allow cells to survive in the face of significant DNA damage as well as cues that foster cell proliferation. This study …
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Terminalia ivorensis and human health: the impact of Terminalia ivorensis on biomarkers of cyto- and genotoxicity in human cells in vitro.
… the impact of TI on biomarkers of cyto- and genotoxicity in human colon and liver cells in vitro. Fresh TI samples were collected in the dry and rainy seasons from Asakakra Kwahu, Eastern region of Ghana, and a TI sample that had been stored at room temperature for 4 years was also used. The …
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Effects of pollution on marine crustaceans in Qatari waters : a baseline survey and a case study on genotoxicity indicators in an endemic shrimp
In this thesis the baseline and seasonal variations of the trace metals (TM) (Arsenic (As), Cadmium (Cd), Cobalt (Co), Chromium (Cr), Copper (Cu), Iron (Fe), Manganese (Mn), Nickel (Ni), Lead (Pb), Vanadium (V) and Zinc (Zn). Methylmercury (CH3Hg), organotins (OT) and polychlorinated biphenyls …
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In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
… and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… applications, there are concerns about their genotoxicity on human DNA. Published genotoxicity studies on GO NMs were performed using non-commercial GO with 2-3 layers of GO sheets, synthesized in various laboratories with the potential for inter-laboratory variabilities. However, what has not …
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Effects of Graphene Oxide in vitro on DNA Damage in Human Whole Blood and Peripheral Blood Lymphocytes from Healthy individuals and Pulmonary Disease Patients: Asthma, COPD, and Lung Cancer
… applications, there are concerns about their genotoxicity on human DNA. Published genotoxicity studies on GO NMs were performed using non-commercial GO with 2-3 layers of GO sheets, synthesized in various laboratories with the potential for inter-laboratory variabilities. However, what has not …
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Quantitative, Comparative Toxicity and Toxicogenomic Analyses of Nitrogenous Drinking Water Disinfection by-Products
… comparative, mammalian cell cytotoxicity and genotoxicity database. The particular focus of this dissertation was on nitrogen containing DBPs. Based on our previous results, bromoacetic acid, was utilized in a pioneering human toxicogenomic study. Normal, non-transformed human embryonic cells …
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The Effects of Radon and its Progeny on Human Skin Cells
… radiation (UVR). Cell viability, cytotoxicity, genotoxicity, and mode of cell death was ascertained using neutral red uptake, lactate dehydrogenase, and comet assays, and dual stain flow cytometry respectively. UVR alone induced a cytotoxic dose response more rapidly in skin cells than lung …
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