Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"genomics research"”.
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African researchers' perceptions and expectations of the benefits of genomics research in Africa : a qualitative study
Introduction: Genomics research raises a number of ethical, legal and social issues (ELSI), one of which is the concept of benefit sharing. While benefits and benefit sharing are difficult to discuss because of questions on what needs to be shared, with whom and by whom, it cannot be pushed to the …
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SEE. I AM ONE. BALANCING POWER IN GENOMICS RESEARCH OF CONSTRUCTED WETLANDS TO CLEAN OIL SANDS TAILINGS WATER
… water (OSPW), I was positioned to study the researchers, research, and community perspectives, to contribute to a gap on how these collaborations can increase their effectiveness in using multiple ways of knowing. My work proposed to even-out power imbalances in several ways; studying the …
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Stigma and African genomics research: An exploration of stigma associated with the genetic attribution of rheumatic heart disease
… and generating richer data in qualitative research. In addition to explore the impact of genetic attribution on stigma, this thesis also evaluates the efficacy of visual in qualitative research. Methods: Given that this paper has two components, one investigating the impact of genetic …
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Developing a Principles-Based Framework to Link the Governance of Genomics Research and Biobanking in Africa to Global Health Justice
Background Genomics research has introduced significant transformations in the way health research is traditionally structured. Firstly, genomics research often requires long-term storage of biological samples for future unspecified uses. Secondly, the stored samples may be shared with researchers …
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Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
… in 2006) with the Center for Drug Evaluation and Research (CDER)---despite rapidly escalating R&D spending among the world's major pharmaceutical firms (the "majors"). Industry leaders, researchers, and observers have all but acknowledged this drug discovery productivity crisis, much of it …
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Using Domination to Analyze RNA Structures.
<p>Understanding RNA molecules is important to genomics research. Recently researchers at the Courant Institute of Mathematical Sciences used graph theory to model RNA molecules and provided a database of trees representing possible secondary RNA structures. In this thesis we use domination …
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Laying the Foundation in Genetic Medicine: Understanding Why African Americans and Hispanic/Latinos are Underrepresented in Genetic Testing and in Genetic Research
… it comes to participating in medical genetics research opportunities and also in genetic testing (Shavers, Lynch, & Burmeister, 2002). Lack of participation among African-American individuals can attributed to mistrust, due to past misuse in clinical research settings such as the Tuskegee …
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Long-range Genomics Benchmark Technology and More
… processing capabilities. In the context of genomics, where dependencies often span over 100,000 base pairs, the quadratic computational complexity of the attention mechanism, a core feature of the transformer architecture, poses a significant bottleneck. With the goal of creating a genomics …
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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
… (HIV)/acquired immunodeficiency syndrome (AIDS). Genomics research has the potential to improve the health of Africans through identification of genetic markers associated with either disease susceptibility or therapeutic drug response. This project was set to investigate the genetic correlates …
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Systems support for genomics computing in cloud environments
<p>Genomics research has enormous applications in many areas such as health care, forensic, agriculture, etc. Most recent achievements in this field come from the availability of the unprecedented genomic data. However, new sequencing technologies in genomics keep producing data at a faster pace …
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Bioinformatics framework for genotyping microarray data analysis
Functional genomics is a flourishing science enabled by recent technological breakthroughs in high-throughput instrumentation and microarray data analysis. Genotyping microarrays establish the genotypes of DNA sequences containing single nucleotide polymorphisms (SNPs), and can help biologists …
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Precision Medicine and It's Ethical and Social Implications: Public Health and Gobal Persepctives
… with the capacity to “empower patients, researchers, and providers to work together toward the development of individualized care,” through research, technologies, and policies (President Obama, 2015). Precision Medicine (PM), in the form of genomics, offers unprecedented promise of …
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Returning individual genetic results to research participants: experiences of stigma in South African families with neurodevelopmental disorders
In South Africa, there is little research about the experiences of stigma in parents or caregivers of children with a Neurodevelopmental Disorder (NDD). Likewise, the impact of genetic attribution on these experiences have not been extensively studied. The aim of this study was to explore the …
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Exploring how a genetic attribution to disease relates to internalised stigma experiences of Xhosa people with schizophrenia and rheumatic heart disease in South Africa
Advances in genomics research have brought forth a number of psychosocial concerns. In Africa, in particular, one of the concerns relates to the potential impact of genomics research on stigma experienced by specific population groups. Using a mixed-methods approach, this study sought to explore …
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Expectations and Preferences of Parents and Adolescents Regarding Feedback of Individual Genetic Findings in an HIV-TB Genomic Research Project in Botswana
… There has been tremendous progress in the use of genomics1 in biomedical research and medical care since the launch of the Human Genome Project in 1990. However, it has also introduced new ethical challenges regarding the feedback of findings generated in genomic sequencing. While some would argue …
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Cancer risk prediction with next generation sequencing data using machine learning
… (NGS) analysis is rapidly increasing in genomics research. However, the effectiveness of NGS data to predict disease abundance is yet unclear. This research investigates the problem in the whole exome NGS data of the chronic lymphocytic leukemia (CLL) available at dbGaP. Initially, raw …
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Advances in spatial modeling for complex data with applications to symbolic data and spatial transcriptomics.
… in environmental, public health, and genomics research.
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Analysis of value creation and value capture in microfluidics market
… tremendous technological value which is shaping genomics; drug discovery; proteomics; and point-of-care diagnostics. The positive impact has resulted in faster analysis time, increased throughput and reduced cost amongst other important benefits. Yet, the life sciences end-users and the …
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Co-linear Chaining on Graphs With Cycles
… has been an increasingly useful tool in pan-genomics research. Therefore, sequence-to-graph alignment becomes an important and challenging problem. For pairwise approximate sequence alignment under Levenshtein (edit) distance, subquadratic algorithms for finding an optimal solution are …
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Computational analysis of cis-regulatory mechanisms underlying cellular response to drug perturbations
… disparate subfields of biology: pharmacogenomics and regulatory genomics. The former concentrates on how inherited factors such as SNPs and genes inform the response to medical interventions designed to ameliorate disease states, processes, and phenotypes; ontologically, it resides at the …
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