Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"genomic variations"”.
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Intra-species genomic variations in hydrogen-oxidising bacteria is delineated by horizontal gene flow
… recombining bacteria independent of their genomic background. Thus, discontinuities in horizontal gene flow can be utilised to demarcate a genotypically and ecologically cohesive bacterial species. Previous studies have demonstrated that ecological populations exist in heterotrophic …
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Characterization of Genomic Variation Related to Hair and Skin Phenotypes in the Khoesan Speakers of Southern Africa
… to their local environment, we analyzed genomic variations of Khoesan individuals with scans of natural selection, and identified variants that may be targets of selection in the Keratin (KRT) gene family. We examined a potential regulatory variant in KRT78, rs7307165, and conducted a …
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Genetic diversity and population structure within Botswana: association with HIV-1 infection
… variation. Characterisation of human genetic variations can contribute towards understanding the genetic aetiology of HIV-1 and foster development of novel preventive and treatment strategies against HIV-1. Despite the high burden of HIV-1 in Botswana, the population of Botswana is …
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GENOMICS OF EFFICIENCY, RESILIENCE AND BIODIVERSITY IN HOLSTEIN AND LOCAL CATTLE BREEDS
This thesis explores the genomics of biodiversity, resilience, and efficiency in Holstein (a cosmopolitan population) and local cattle breeds, focusing on their genetic diversity, adaptation to environmental challenges and the application of genomic tools in breeding programs. The research …
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The Resource Environment and Microbial Associations Mediate Adaptation to Environmental Heterogeneity in Drosophila Melanogaster
… evolutionary biology. The ability to observe the genomic and phenotypic evolution of populations over rapid timescales has enabled a deeper exploration into the role particular environmental variables have on a population’s response to selection. While replicate populations of Drosophila …
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Genotypes of SNPs of Key Genes Regulate Susceptibility and Drug Sensitivity to Neovascular AMD
… nucleotide polymorphisms (SNPs), as primary genomic variations, are linked to disease susceptibility and treatment sensitivity, including in nAMD. This study posits that SNP interactions within human genes may influence anti-VEGF drug’s efficacy, supported by evidence on the distinct …
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Proteome-Seq: Sequencing-Based Readout Of Proteomic Analytical Assay
… multiple factors, including environmental cues, genomic variations, epigenetic modifications, transcriptional dynamics and the vast complexity of proteome. While RNA sequencing is a workhorse of high-resolution single-cell analysis, it captures cellular states pre protein translation. …
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Analysis of two single trait loci affecting flavonol glycoside accumulations in Arabidopsis thaliana natural variations
… can be investigated and used to identify genomic variations causing observed traits. The work presented in this thesis is focused on the identification of new genes involved in accumulation of flavonoid derivatives in A. thaliana wildtype accessions using both metabolomics and genomic …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… are able to build engines leveraging massive genomic variations and integrating with clinical data to identify “at risk” individuals for the sake of prevention, diagnosis and therapeutic interventions. In my graduate work for my Ph.D. thesis, I have investigated genomic sequencing data mining …
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High resolution optical DNA mapping
… and autism are associated with copy-number variations in the genome. Most of these variations could not be identified with existing sequencing and optical DNA mapping methods. We have developed Multi-color Super-resolution technique, with potential for high throughput and low cost, which can …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… of drugs and there is a limited data on pharmacogenomics of SCD therapeutics. Vaso-occlusive crisis (VOC) are the main clinical events of SCD and are associated with recurrent and long-term use of antalgics/opioids and HU. This project aimed to investigate the clinical and genetic predictors of …
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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?
… make the pseudoviruses were also sequenced and genomic variations in variable loop characteristics (length and number of potential glycosylation sites) between blood and semen compared. Chapter 4: Sensitivity of blood and semen variants to autologous and heterologous antibodies To study the …