Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"genomic imprinting"”.
-
Dynamics of DNA methylation and genomic imprinting in arabidopsis
… processes, ranging from transposon silencing to genomic imprinting. In plants, DNA methylation is both mitotically and meiotically heritable, and changes in DNA methylation can be generationally stable and have long-lasting consequences. This thesis aims to improve understanding of DNA …
-
A genetic investigation of the establishment of genomic imprinting
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
-
Consequences of mitotic loss of heterozygosity on genomic imprinting in mouse embryonic stem cells
… functionally inequivalent, a phenomenon called genomic imprinting. This functional inequivalence is exemplified with imprinted genes, whose expression is parent-of-origin specific. The dosage of imprinted gene expression is disrupted in cells with uniparental disomy (UPD), which is an unequal …
-
Expression Analysis of the Imprinted Gene Transketolase-like 1 in Mouse and Human
<p>Genomic imprinting is an epigenetic phenomenon resulting in differential gene expression based on parental origin. Recently, <em>transketolase-like 1</em> (<em>TKTL1</em>) has been identified as an X-linked imprinted gene. TKTL1 functions in the nonoxidative branch of the pentose phosphate …
-
Statistical power for RNA-seq data to detect two epigenetic phenomena
… DNA sequence. Two epigenetic phenomena, genomic imprinting and Allelic Expression Imbalance (AEI), are discussed in this dissertation. RNA-seq is a powerful new technology for mapping and quantifying transcriptomes using ultra high throughput next generation sequencing technologies. Using …
-
The epigenetics and role of Dopa Decarboxylase in heart development
Genomic imprinting in mammals subjects a handful of genes to silencing on one allele depending on the parent-of-origin of that allele. The Ddc_exonla gene transcript is under the control of genomic imprinting in the developing and neonatal mouse heart with transcription occurring solely on the …
-
AN ANALYSIS OF THE DIFFERENTIAL METHYLATION AND EXPRESSION OF IMPRINTED GENES IN M. M. MUSCULUS, M. M. DOMESTICUS, AND THEIR HYBRIDS
… is a type of epigenetic modification. Genomic imprinting is a pattern of gene expression that is primarily achieved through DNA methylation, and it results in the expression of only one allele at a particular locus. In this study, I analyzed the methylation patterns of five imprinted …
-
Monoallelic Gene Expression In Human Neural Stem Cells
… in the form of X-chromosome inactivation, genomic imprinting and random monoallelic expression (RME) of a small number of gene families. More recently, studies have reported evidence of widespread autosomal RME in human lymphoblastoid cells (Gimelbrant et al. 2007) and mouse neural stem …
-
Deciphering the genetic and epigenetic basis of human imprinting and chromatin disorders
… methylation patterns, including disturbances in genomic imprinting, have been linked to congenital imprinting disorders as well as various disease conditions, including cancer, chromatin disorders, and neurodevelopmental disorders. Some imprinting disorders, however, result in alterations in …
-
The Regulation of Dna Methylation In Mammalian Development and Cancer
… maintenance of chromosomal structure and genomic stability, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Dysregulation of DNA methylation is associated with various human diseases. For example, cancer cells usually show global hypomethylation and regional …
-
DNA methylation analysis and identification of a novel antisense transcript in the Peg3 imprinted domain
Genomic imprinting is a process that leads to the silencing of one allele of a gene in a parent of origin specific manner. Genes that are involved in this process are often regulated in clusters, one of which is the Peg3 (Paternally expressed gene 3) imprinted domain. We investigated this region …
-
Molekulargenetische Analyse eines evolutionär konservierten Silencer-Elements aus dem murinen H19-Locus in Drosophila melanogaster
Die genomische Prägung (“Genomic Imprinting“) bestimmter Säugergene resultiert in ihrer allelspezifischen Expression. Die monoallelische Expression genomisch geprägter Gene wird durch ein Zusammenwirken cis-regulatorischer DNA-Elemente kontrolliert, zu denen differentiell methylierte Regionen, …
-
Investigating the impact of pharmacological exposures on the developing epigenome
… and dynamic gene expression patterns. Genomic imprinting is an epigenetic process found in eutherian and metatherian mammals, which results in parent-of-origin specific expression. There are currently over 100 described imprinted genes in the mammalian genome and these genes have been …
-
Regulation of the Kcnq1ot1 Imprinting Domain in Mouse
Genomic imprinting is an epigenetic mechanism that controls gene expression based on parental-origin of an allele. The Kcnq1ot1 imprinting cluster consists of an imprinting control region (ICR), the Kcnq1ot1 ncRNA, and maternally expressed protein-coding genes. Truncation of the Kcnq1ot1 ncRNA or …
-
ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
… role in governing cellular processes including genomic imprinting, gene expression, and development. Recently, the Tet family of methylcytosine dioxygenases(Tet1, Tet2 and Tet3) was found to catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in …
-
Using synthetic biology to investigate human gene body DNA methylation
… modification important in development, genomic imprinting and gene regulation. Classically, methylation at promoters is associated with transcriptional repression, whereas methylation within gene bodies has been correlated with highly expressed genes. This has led to the hypothesis that …
-
Νευραναπτυξιακές διαταραχές στην υποβοηθούμενη αναπαραγωγή
… μηχανισμών και της γονιδιακής αποτύπωσης (genomic imprinting). Οι τεχνητές συνθήκες της εργαστηριακής γονιμοποίησης, της κρυοσυντήρησης και της καλλιέργειας εμβρύων ενδέχεται να επηρεάζουν τη φυσιολογική μεθυλίωση του DNA και άλλους μηχανισμούς ρύθμισης της γονιδιακής έκφρασης. Παρότι η …
-
Towards elucidating the function of the oocyte Subcortical Maternal Complex: A multi-omic analysis of an Nlrp5-null murine model
… embryo arrest, recurrent molar pregnancies and imprinting disorders. Genomic imprinting depends upon correct patterning of DNA methylation over imprinted domains during oogenesis. It was previously shown that oocytes deficient in the human SCMC gene *KHDC3L* had globally impaired methylation, …
-
Exploring functional significance of asymmetric DNA methylation in early mammalian development
… of transcriptional activity in processes like genomic imprinting, retrotransposon silencing and centromeric stabilisation. It is also crucial for correct embryonic development and the differentiation of embryonic stem cells (ESCs) into diverse cell types. Although in mammals DNA methylation …
Page 1 of 2